Zobrazeno 1 - 10
of 453
pro vyhledávání: '"H. Heim"'
Autor:
Kostas C. Nikolaou, Svenja Godbersen, Muthiah Manoharan, Stefan Wieland, Markus H. Heim, Markus Stoffel
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Nonalcoholic steatohepatitis (NASH) is a leading cause for chronic liver diseases. Current therapeutic options are limited due to an incomplete mechanistic understanding of how steatosis transitions to NASH. Here we show that the TRIM21 E3 ubiquitin
Externí odkaz:
https://doaj.org/article/f988f56d53784cf294e71475462e5233
Autor:
Marie-Anne Meier, Sandro Nuciforo, Mairene Coto-Llerena, John Gallon, Matthias S. Matter, Caner Ercan, Jürg Vosbeck, Luigi M. Terracciano, Savas D. Soysal, Daniel Boll, Otto Kollmar, Raphaël Delaloye, Salvatore Piscuoglio, Markus H. Heim
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-8 (2022)
Meier, Nuciforo, Coto-Llerena et al. report a rare case of a patient with hepatocellular carcinoma with neuroendocrine differentiation. The authors establish organoids that recapitulate the genetic features of the patient’s tumor and are used for e
Externí odkaz:
https://doaj.org/article/092df1cdee254031870f4d0caaa0bd75
Autor:
Polina Suter, Eva Dazert, Jack Kuipers, Charlotte K Y Ng, Tuyana Boldanova, Michael N Hall, Markus H Heim, Niko Beerenwinkel
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1009767 (2022)
Comprehensive molecular characterization of cancer subtypes is essential for predicting clinical outcomes and searching for personalized treatments. We present bnClustOmics, a statistical model and computational tool for multi-omics unsupervised clus
Externí odkaz:
https://doaj.org/article/00fabc0f584743428d737f10c282a558
Autor:
Ruize Gao, David Buechel, Ravi K. R. Kalathur, Marco F. Morini, Mairene Coto-Llerena, Caner Ercan, Salvatore Piscuoglio, Qian Chen, Tanja Blumer, Xueya Wang, Eva Dazert, Markus H. Heim, Michael N. Hall, Fengyuan Tang, Gerhard Christofori
Publikováno v:
Oncogenesis, Vol 10, Iss 7, Pp 1-13 (2021)
Abstract Understanding the mechanisms underlying evasive resistance in cancer is an unmet medical need to improve the efficacy of current therapies. In hepatocellular carcinoma (HCC), aberrant expression of hypoxia-inducible factor 1 α (HIF1α) and
Externí odkaz:
https://doaj.org/article/e03d208eef10428d9173423f817695c2
Publikováno v:
Viruses, Vol 14, Iss 11, p 2490 (2022)
Infectious diseases are a major contributor to human suffering and the associated socioeconomic burden worldwide. A better understanding of human pathogen-host interactions is a prerequisite for the development of treatment strategies aimed at combat
Externí odkaz:
https://doaj.org/article/bbd7a68076af4a9d9f38768564409efc
Autor:
Wenjuan Pu, Huan Zhu, Mingjun Zhang, Monika Pikiolek, Caner Ercan, Jie Li, Xiuzhen Huang, Ximeng Han, Zhenqian Zhang, Zan Lv, Yan Li, Kuo Liu, Lingjuan He, Xiuxiu Liu, Markus H. Heim, Luigi M. Terracciano, Jan S. Tchorz, Bin Zhou
Publikováno v:
Nature Genetics. 55:651-664
Following severe liver injury, when hepatocyte-mediated regeneration is impaired, biliary epithelial cells (BECs) can transdifferentiate into functional hepatocytes. However, the subset of BECs with such facultative tissue stem cell potential, as wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cd6ea7a076a9477e14fcd9e6887473c
https://doi.org/10.1038/s41588-023-01335-9
https://doi.org/10.1038/s41588-023-01335-9
Autor:
Sandro Nuciforo, Markus H. Heim
Publikováno v:
JHEP Reports, Vol 3, Iss 1, Pp 100198- (2021)
Summary: The organoid model represents a major breakthrough in cell biology that has revolutionised biomedical research. Organoids are 3D physiological in vitro structures that recapitulate morphological and functional features of in vivo tissues and
Externí odkaz:
https://doaj.org/article/a94502ce34414b44b319615c9f875689
Autor:
Huong T L Tran, Kenichi Morikawa, Anggakusuma, Rose Zibi, Viet Loan Dao Thi, François Penin, Markus H Heim, Manfredo Quadroni, Thomas Pietschmann, Jérôme Gouttenoire, Darius Moradpour
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236447 (2020)
The hepatitis C virus (HCV) nonstructural protein 3-4A (NS3-4A) protease is a key component of the viral replication complex and the target of protease inhibitors used in current clinical practice. By cleaving and thereby inactivating selected host f
Externí odkaz:
https://doaj.org/article/92585b5b50cd407a937b9f53b4654bb5
Autor:
Diego Calabrese, Guglielmo Roma, Sebastian Bergling, Walter Carbone, Valentina Mele, Sandro Nuciforo, Isabel Fofana, Benedetta Campana, Dagmara Szkolnicka, David C Hay, Jan Tchorz, Tewis Bouwmeester, Stefan Wieland, Markus H Heim
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221762 (2019)
Background & aimsHepatocyte-like cells (HLCs) differentiated from induced pluripotent stem cells (iPSCs) have emerged as a promising cell culture model to study metabolism, biotransformation, viral infections and inherited liver diseases. iPSCs provi
Externí odkaz:
https://doaj.org/article/eab6c893049b48f6b2729aa696405960
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Context Metabolic dysfunction–associated fatty liver disease (MAFLD) is highly prevalent among patients with type 2 diabetes mellitus (T2DM); however, there is still no approved pharmacological treatment. Sodium-glucose cotransporter 2 (SGLT-2) inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a944d69bb17b67b7097aec1573c50b28
https://doi.org/10.1210/clinem/dgad249
https://doi.org/10.1210/clinem/dgad249