Zobrazeno 1 - 10
of 4 593
pro vyhledávání: '"H. Heim"'
Autor:
Xiaonan Zhang, Natallia Rameika, Lei Zhong, Verónica Rendo, Margus Veanes, Snehangshu Kundu, Sandro Nuciforo, Jordan Dupuis, Muhammad Al Azhar, Ioanna Tsiara, Pauline Seeburger, Shahed Al Nassralla, Viktor Ljungström, Richard Svensson, Ivaylo Stoimenov, Per Artursson, Markus H. Heim, Daniel Globisch, Tobias Sjöblom
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105368- (2024)
Summary: Background: Loss of heterozygosity (LOH) diminishes genetic diversity within cancer genomes. A tumour arising in an individual heterozygous for a functional and a loss-of-function (LoF) allele of a gene occasionally retain only the LoF allel
Externí odkaz:
https://doaj.org/article/c93831231c574e67b595b2f52334f442
Autor:
Sofia Schaeffer, Christian Lutz, Michael Dobbie, Luigi M. Terracciano, Matthias Matter, Jürg Vosbeck, Markus H. Heim, Christine Bernsmeier
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundIdiosyncratic drug-induced liver injury (DILI) is a rare, unpredictable hepatic adverse event and the most common cause of acute liver failure in Europe and the US. Ribociclib is a potent Cyclin-dependent kinase 4 and 6 (CDK4/6)-inhibitor a
Externí odkaz:
https://doaj.org/article/89aa1a97aca843faafac9d5b4d159c2c
Autor:
Kostas C. Nikolaou, Svenja Godbersen, Muthiah Manoharan, Stefan Wieland, Markus H. Heim, Markus Stoffel
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Nonalcoholic steatohepatitis (NASH) is a leading cause for chronic liver diseases. Current therapeutic options are limited due to an incomplete mechanistic understanding of how steatosis transitions to NASH. Here we show that the TRIM21 E3 ubiquitin
Externí odkaz:
https://doaj.org/article/f988f56d53784cf294e71475462e5233
Autor:
Marie-Anne Meier, Sandro Nuciforo, Mairene Coto-Llerena, John Gallon, Matthias S. Matter, Caner Ercan, Jürg Vosbeck, Luigi M. Terracciano, Savas D. Soysal, Daniel Boll, Otto Kollmar, Raphaël Delaloye, Salvatore Piscuoglio, Markus H. Heim
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-8 (2022)
Meier, Nuciforo, Coto-Llerena et al. report a rare case of a patient with hepatocellular carcinoma with neuroendocrine differentiation. The authors establish organoids that recapitulate the genetic features of the patient’s tumor and are used for e
Externí odkaz:
https://doaj.org/article/092df1cdee254031870f4d0caaa0bd75
Autor:
Charlotte K. Y. Ng, Eva Dazert, Tuyana Boldanova, Mairene Coto-Llerena, Sandro Nuciforo, Caner Ercan, Aleksei Suslov, Marie-Anne Meier, Thomas Bock, Alexander Schmidt, Sylvia Ketterer, Xueya Wang, Stefan Wieland, Matthias S. Matter, Marco Colombi, Salvatore Piscuoglio, Luigi M. Terracciano, Michael N. Hall, Markus H. Heim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage, HBV-associated tumours and lacked information about the phosphoproteome. Here, the authors present a comprehensive HCC proteogenomics and phosphoproteomics study i
Externí odkaz:
https://doaj.org/article/0be87e27f0b443f98c2f8990e784ddcb
Autor:
John Gallon, Mairene Coto‐Llerena, Caner Ercan, Gaia Bianco, Viola Paradiso, Sandro Nuciforo, Stephanie Taha‐Melitz, Marie‐Anne Meier, Tujana Boldanova, Sofía Pérez‐del‐Pulgar, Sergio Rodríguez‐Tajes, Markus vonFlüe, Savas D. Soysal, Otto Kollmar, Josep M. Llovet, Augusto Villanueva, Luigi M. Terracciano, Markus H. Heim, Charlotte K. Y. Ng, Salvatore Piscuoglio
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 665-682 (2022)
Hepatocellular carcinomas (HCCs) usually arise from chronic liver disease (CLD). Precancerous cells in chronically inflamed environments may be ‘epigenetically primed’, sensitising them to oncogenic transformation. We investigated whether epigene
Externí odkaz:
https://doaj.org/article/01ede92b5b01440d89da11c31958e65e
Autor:
Caner Ercan, Mairene Coto-Llerena, John Gallon, Lana Fourie, Mattia Marinucci, Gabriel F. Hess, Jürg Vosbeck, Stephanie Taha-Mehlitz, Tuyana Boldanova, Marie-Anne Meier, Alexandar Tzankov, Matthias S. Matter, Martin H. K. Hoffmann, Luca Di Tommaso, Markus von Flüe, Charlotte K. Y. Ng, Markus H. Heim, Savas D. Soysal, Luigi M. Terracciano, Otto Kollmar, Salvatore Piscuoglio
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-8 (2022)
Plain language summary Focal nodular hyperplasia (FNH) is a lesion resulting from the abnormal growth of liver cells. It is typically considered a benign tumor that does not become malignant. In rare cases, FNH may occur alongside malignant hepatocel
Externí odkaz:
https://doaj.org/article/49161dc05fb841fc951e15d1ae5a8794
Autor:
Polina Suter, Eva Dazert, Jack Kuipers, Charlotte K Y Ng, Tuyana Boldanova, Michael N Hall, Markus H Heim, Niko Beerenwinkel
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1009767 (2022)
Comprehensive molecular characterization of cancer subtypes is essential for predicting clinical outcomes and searching for personalized treatments. We present bnClustOmics, a statistical model and computational tool for multi-omics unsupervised clus
Externí odkaz:
https://doaj.org/article/00fabc0f584743428d737f10c282a558
Autor:
Qian Chen, Mairene Coto-Llerena, Aleksei Suslov, Raphael Dias Teixeira, Isabel Fofana, Sandro Nuciforo, Maike Hofmann, Robert Thimme, Nina Hensel, Volker Lohmann, Charlotte K. Y. Ng, George Rosenberger, Stefan Wieland, Markus H. Heim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
A genetic variant in the IFN-lambda 4 gene has been associated with poor hepatitis C virus prognosis but it is not clear how this functions. Here the authors show that IFN-lambda 4 promotes ER stress and inhibits presentation of HCV epitopes to CD8+
Externí odkaz:
https://doaj.org/article/490276d24a40458c86a47d3c716fb078
Autor:
Ruize Gao, David Buechel, Ravi K. R. Kalathur, Marco F. Morini, Mairene Coto-Llerena, Caner Ercan, Salvatore Piscuoglio, Qian Chen, Tanja Blumer, Xueya Wang, Eva Dazert, Markus H. Heim, Michael N. Hall, Fengyuan Tang, Gerhard Christofori
Publikováno v:
Oncogenesis, Vol 10, Iss 7, Pp 1-13 (2021)
Abstract Understanding the mechanisms underlying evasive resistance in cancer is an unmet medical need to improve the efficacy of current therapies. In hepatocellular carcinoma (HCC), aberrant expression of hypoxia-inducible factor 1 α (HIF1α) and
Externí odkaz:
https://doaj.org/article/e03d208eef10428d9173423f817695c2