Zobrazeno 1 - 10
of 22
pro vyhledávání: '"H. Heaslet"'
Autor:
Melissa S. Harris, Veerabahu Shanmugasundaram, Jae-Hyun Cho, Parag Sahasrabudhe, Kris A. Borzilleri, Anil Rane, H. Heaslet, Alex McColl, Boris A. Chrunyk, Henry Putz, Mark Edward Flanagan, Arthur G. Palmer, Brian M. Lacey, Chakrapani Subramanyam, Tim Subashi, Kelly C. Fahnoe, Magee Thomas Victor, Ron Sarver, George A. Karam, J. Richard Miller, Jane M. Withka
Publikováno v:
Applied Biophysics for Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b21d628db86c53d3c2e4007bbc52d101
https://doi.org/10.1002/9781119099512.ch13
https://doi.org/10.1002/9781119099512.ch13
Publikováno v:
Journal of Structural Biology. 167:129-135
Bacterial cell wall transglycosylases (TGs) and transpeptidases (TPs) are ideal drug targets due to their essentiality, accessibility and lack of mammalian homologs. Although antibacterial therapy using the beta-lactam family of TP inhibitors has bee
Autor:
Michael J. Giffin, John H. Elder, Ying-Chuan Lin, H. Heaslet, Chi-Huey Wong, Bruce E. Torbett, Ashraf Brik, C. David Stout, Gabrielle Cauvi, Duncan E. McRee
Publikováno v:
Journal of Medicinal Chemistry. 51:6263-6270
Treatment with HIV-1 protease inhibitors, a component of highly active antiretroviral therapy (HAART), often results in viral resistance. Structural and biochemical characterization of a 6X protease mutant arising from in vitro selection with compoun
Autor:
K. Tam, Ying-Chuan Lin, C.D. Stout, Robin J. Rosenfeld, Michael J. Giffin, Bruce E. Torbett, H. Heaslet, John H. Elder, Duncan E. McRee
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 63:866-875
The crystal structures of wild-type HIV protease (HIV PR) in the absence of substrate or inhibitor in two related crystal forms at 1.4 and 2.15 A resolution are reported. In one crystal form HIV PR adopts an 'open' conformation with a 7.7 A separatio
Autor:
Ying-Chuan Lin, John H. Elder, H. Heaslet, Garrett M. Morris, Bruce E. Torbett, Victoria D Kutilek, C. David Stout
Publikováno v:
Journal of Molecular Biology. 356:967-981
The development of resistance to anti-retroviral drugs targeted against HIV is an increasing clinical problem in the treatment of HIV-1-infected individuals. Many patients develop drug-resistant strains of the virus after treatment with inhibitor coc
Autor:
J. Richard Miller, Gabriela Barreiro, Ronald W. Sarver, Melissa S. Harris, Jeanne Chang, Kelly C. Fahnoe, Chakrapani Subramanyam, Henry Putz, H. Heaslet
Publikováno v:
Proteins. 76(3)
Dihydrofolate reductase (DHFR) is the enzyme responsible for the NADPH-dependent reduction of 5,6-dihydrofolate to 5,6,7,8-tetrahydrofolate, an essential cofactor in the synthesis of purines, thymidylate, methionine, and other key metabolites. Becaus
Autor:
Artem G. Evdokimov, Denis Kole, R.L. Walter, Chunhong Yan, Marlene Mekel, Patrick I. McConnell, Fang Sun, Eric B. Fauman, Teresa McGrath, Lakshmi Narasimhan, Craig Banotai, Jia Liu, Bryan Beattie, Loola Al-Kassim, H. Heaslet, Tod P. Holler, Weijun Ma, Barry C. Finzel, Paul Wengender, Peter L. Toogood, Kim Hutchings, Norman Garceau, Timothy Braden, Jeffrey F. Ohren, Cindy Spessard
Publikováno v:
Journal of structural biology. 162(1)
In this article, we describe for the first time the high-resolution crystal structure of a phenylalanine tRNA synthetase from the pathogenic bacterium Staphylococcus haemolyticus. We demonstrate the subtle yet important structural differences between
Publikováno v:
Retrovirology, Vol 4, Iss 1, p 1 (2007)
Retrovirology
Retrovirology
We have obtained the 1.7 Å crystal structure of FIV protease (PR) in which 12 critical residues around the active site have been substituted with the structurally equivalent residues of HIV PR (12X FIV PR). The chimeric PR was crystallized in comple
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Akademický článek
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