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Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression

Autor: H. Haddada, M. A. Abina, Françoise Pflumio, William Vainchenker, Najet Debili, Jean-Luc Villeval, Catherine Lacout, Françoise Wendling, M. Tulliez

Publikováno v: Gene therapy. 5(4)

Adenoviral vectors may be useful tools to deliver a cytokine in vivo. A single intravenous injection of an adenovirus vector containing the human thrombopoietin (TPO) cDNA (AdRSVhuTPO) was able to induce a thrombocytosis for more than 6 weeks in SCID

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7923b44991317a6dfd8b6f0d144158e
https://pubmed.ncbi.nlm.nih.gov/9614574

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Does preventive vaccination with engineered tumor cells work in cancer-prone transgenic mice?

Autor: A, Morel, A, de La Coste, N, Fernandez, A, Berson, M, Kaybanda, T, Molina, P, Briand, H, Haddada, J G, Guillet, B, Antoine, M, Viguier, A, Kahn

Publikováno v: Cancer gene therapy. 5(2)

The use of genetically modified tumor cells as vaccines has been successful in numerous animal models of grafted syngenic tumors and has provided the groundwork for many clinical trials of gene therapy in cancer patients. To investigate the real effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62dc7603600b8e7e1afd88c9bdc02a46
https://pubmed.ncbi.nlm.nih.gov/9570300

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IL-2 gene delivery within an established murine tumor causes its regression without proliferation of preexisting antitumor-specific CTL

Autor: J P, Levraud, M T, Duffour, L, Cordier, M, Perricaudet, H, Haddada, P, Kourilsky

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 158(7)

Regression of P815 tumors established on naive syngeneic mice can be obtained by the intratumoral injection of a single dose of an adenoviral vector expressing the IL-2 gene (Ad.IL2). Injection triggers local IL-2 production for at least 10 days. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a3beeeeb0e1bf6c960aa20e34e085f7
https://pubmed.ncbi.nlm.nih.gov/9120291

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LacZ gene transfer into tumor cells abrogates tumorigenicity and protects mice against the development of further tumors

Autor: M A, Abina, M G, Lee, V, Descamps, L, Cordier, M, Lopez, M, Perricaudet, H, Haddada

Publikováno v: Gene therapy. 3(3)

Numerous studies have shown that the expression of immuno-stimulatory genes in tumor cells can result in the development of antitumoral immunity resulting in the rejection of the tumor cells. We show here that the simple integration and expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db1d841bf7c4e11d2f9052d3a5de65b7
https://pubmed.ncbi.nlm.nih.gov/8646551

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Differential efficacy of adenoviral mediated gene transfer into cells from hematological cell lines and fresh hematological malignancies

Autor: E, Wattel, M, Vanrumbeke, M A, Abina, N, Cambier, C, Preudhomme, H, Haddada, P, Fenaux

Publikováno v: Leukemia. 10(1)

As a first step to evaluate the possibility of gene therapy using adenoviral vectors in hematological malignancies in vivo, we tested the efficacy of gene transfer by a recombinant adenovirus in cell lines and fresh cells from various hematological n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f445adbf607323274b0919419e84c000
https://pubmed.ncbi.nlm.nih.gov/8558924

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The constitutive expression of the immunomodulatory gp19k protein in E1-, E3- adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector

Autor: M G, Lee, M A, Abina, H, Haddada, M, Perricaudet

Publikováno v: Gene therapy. 2(4)

The immune response against cells infected by gene therapy vectors may be a major hindrance for gene therapy, destroying infected cells thus limiting the length of exogene expression and quickly eliminating infected cells on repeat administration. Ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78520e99415782cb46c08f9cf2a0126a
https://pubmed.ncbi.nlm.nih.gov/7552985

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Complete recovery of mice from a pre-established tumor by direct intratumoral delivery of an adenovirus vector harboring the murine IL-2 gene

Autor: L, Cordier, M T, Duffour, J C, Sabourin, M G, Lee, J, Cabannes, T, Ragot, M, Perricaudet, H, Haddada

Publikováno v: Gene therapy. 2(1)

Direct introduction of exogenous genes into pre-existent tumors could provide an effective therapeutic approach for treatment of localized tumors. In this report we show that direct intratumoral delivery in animals of a replication-deficient adenovir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02a588e7e327a61bd48529dbbd887ce3
https://pubmed.ncbi.nlm.nih.gov/7712329

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