Výsledky vyhledávání - "H. H. Schrenk"

Mode of action of methotrexate-albumin in a human T-cell leukemia line and activity against an MTX-resistant clone

Autor: M, Weigand, G, Hartung, J, Roboz, S, Sieger, M, Wolf, H, Sinn, H H, Schrenk, M, Wiessler, E, Frei

Publikováno v: Anti-cancer drug design. 16(4-5)

Limitations of low mol. wt anticancer drugs are short tumor exposure times and toxicity to normal tissue. Methotrexate (MTX) covalently linked to human serum albumin (HSA) as a macromolecular carrier caused tumor regressions concomitant with a favora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43d66bad71b1e9bd5ef64905d03932e1
https://pubmed.ncbi.nlm.nih.gov/12049481

Zobrazit plný text záznamu

Phase I trial of methotrexate-albumin in a weekly intravenous bolus regimen in cancer patients. Phase I Study Group of the Association for Medical Oncology of the German Cancer Society

Autor: G, Hartung, G, Stehle, H, Sinn, A, Wunder, H H, Schrenk, S, Heeger, M, Kränzle, L, Edler, E, Frei, H H, Fiebig, D L, Heene, W, Maier-Borst, W, Queisser

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(4)

Methotrexate-albumin conjugate (MTX-HSA) is a novel human albumin-based prodrug conjugate of methotrexate (MTX). A low MTX loading rate provided optimal tumor targeting and therapeutic efficacy during preclinical testing. The objectives of this first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37cc8650adc43d89df19b43614b81671
https://pubmed.ncbi.nlm.nih.gov/10213209

Zobrazit plný text záznamu

Antitumor activity of methotrexate-albumin conjugates in rats bearing a Walker-256 carcinoma

Autor: A, Wunder, G, Stehle, H H, Schrenk, G, Hartung, D L, Heene, W, Maier-Borst, H, Sinn

Publikováno v: International journal of cancer. 76(6)

We have recently reported that albumin accumulates in solid tumors and serves there as a source of nitrogen and energy. Methotrexate-albumin conjugates [MTX(I)-RSA] derivatized at a molar ratio of 1:1 differ favorably from original MTX in terms of pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b504b0da8c62c954105978db3613fc3d
https://pubmed.ncbi.nlm.nih.gov/9626357

Zobrazit plný text záznamu

The loading rate determines tumor targeting properties of methotrexate-albumin conjugates in rats

Autor: G, Stehle, H, Sinn, A, Wunder, H H, Schrenk, S, Schütt, W, Maier-Borst, D L, Heene

Publikováno v: Anti-cancer drugs. 8(7)

Albumin dominates the plasma proteins in man. Following our observation that albumin turnover in rodent tumors is markedly increased, we will present evidence that albumin can be employed as an efficient carrier for targeting cytostatic agents like m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b885d2b8615c20d3848f54fe5c53df8
https://pubmed.ncbi.nlm.nih.gov/9311444

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání