Zobrazeno 1 - 10
of 105
pro vyhledávání: '"H. Grange"'
Autor:
Eizo Marutani, Masanobu Morita, Shuichi Hirai, Shinichi Kai, Robert M. H. Grange, Yusuke Miyazaki, Fumiaki Nagashima, Lisa Traeger, Aurora Magliocca, Tomoaki Ida, Tetsuro Matsunaga, Daniel R. Flicker, Benjamin Corman, Naohiro Mori, Yumiko Yamazaki, Annabelle Batten, Rebecca Li, Tomohiro Tanaka, Takamitsu Ikeda, Akito Nakagawa, Dmitriy N. Atochin, Hideshi Ihara, Benjamin A. Olenchock, Xinggui Shen, Motohiro Nishida, Kenjiro Hanaoka, Christopher G. Kevil, Ming Xian, Donald B. Bloch, Takaaki Akaike, Allyson G. Hindle, Hozumi Motohashi, Fumito Ichinose
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The brain is sensitive to oxygen deprivation. Here, the authors show in experimental animals that sensitivity to hypoxia is inversely related to the level of sulfide:quinone oxidoreductast (SQOR) and the capacity to catabolize sulfide in the brain.
Externí odkaz:
https://doaj.org/article/e9e4bccfec79480492fb63f03e33bd26
Autor:
Shunsaku Goto, Robert M. H. Grange, Riccardo Pinciroli, Ivy A. Rosales, Rebecca Li, Sophie L. Boerboom, Katrina F. Ostrom, Eizo Marutani, Hatus V. Wanderley, Aranya Bagchi, Robert B. Colvin, Lorenzo Berra, Olga Minaeva, Lee E. Goldstein, Rajeev Malhotra, Warren M. Zapol, Fumito Ichinose, Binglan Yu
Publikováno v:
Archives of Toxicology. 96:3363-3371
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a3aaaa843934c0d8f9661614a670437
https://doi.org/10.1007/s00204-022-03388-x
https://doi.org/10.1007/s00204-022-03388-x
Akademický článek
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Autor:
Reshma S. Baliga, Joshua P. Dignam, Amie J Moyes, Robert M. H. Grange, Aisah A. Aubdool, Cristina Perez-Ternero, Michael E. J. Preedy, Aniruthan Renukanthan, Vanessa Lowe, Adrian J. Hobbs
Publikováno v:
British Journal of Pharmacology. 179:2443-2459
cGMP underpins the bioactivity of NO and natriuretic peptides and is key to cardiovascular homeostasis. cGMP-driven responses are terminated primarily by PDEs, but cellular efflux via multidrug resistance proteins (MRPs) might contribute. Herein, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e525914d7bba067aa9fce0f17ad0e33
https://doi.org/10.1111/bph.15593
https://doi.org/10.1111/bph.15593
Autor:
Rebecca Li, Benjamin A. Olenchock, Shinichi Kai, Tomoaki Ida, Yumiko Yamazaki, Hozumi Motohashi, Naohiro Mori, Masanobu Morita, Xinggui Shen, Daniel Flicker, Christopher G. Kevil, Annabelle Batten, Dmitriy N. Atochin, Lisa Traeger, Benjamin Corman, Yusuke Miyazaki, Eizo Marutani, Fumiaki Nagashima, Motohiro Nishida, Kenjiro Hanaoka, Robert M. H. Grange, Aurora Magliocca, Takaaki Akaike, Daniel Bloch, Tetsuro Matsunaga, Takamitsu Ikeda, Shuichi Hirai, Tomohiro Tanaka, Akito Nakagawa, Fumito Ichinose, Ming Xian, Allyson G. Hindle, Hideshi Ihara
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
The mammalian brain is highly vulnerable to oxygen deprivation, yet the mechanism underlying the brain’s sensitivity to hypoxia is incompletely understood. Hypoxia induces accumulation of hydrogen sulfide, a gas that inhibits mitochondrial respirat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b245bdec1dc4755f55c0addef3654b49
https://doaj.org/article/e9e4bccfec79480492fb63f03e33bd26
https://doaj.org/article/e9e4bccfec79480492fb63f03e33bd26
Autor:
Rajeev Malhotra, Bryn Reinstadler, Aranya Bagchi, Daniel Bloch, Hardik Shah, Fumito Ichinose, Robert M. H. Grange, Eizo Marutani, Gregory R. Wojtkiewicz, Vamsi K. Mootha, Marissa K. Cooper, Yusuke Miyazaki, Grigorij Schleifer, Allyson G. Hindle, Akito Nakagawa, Warren M. Zapol, Olga Goldberger, Rohit Sharma, Annabelle Batten
Publikováno v:
Molecular Genetics and Metabolism. 133:83-93
Leigh syndrome is a severe mitochondrial neurodegenerative disease with no effective treatment. In the Ndufs4−/− mouse model of Leigh syndrome, continuously breathing 11% O2 (hypoxia) prevents neurodegeneration and leads to a dramatic extension (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8dfb0c48990bb2740cda981f0aec86
https://doi.org/10.1016/j.ymgme.2021.03.005
https://doi.org/10.1016/j.ymgme.2021.03.005
Autor:
Manjunatha Shivaraju, Warren M. Zapol, Vamsi K. Mootha, Fumito Ichinose, Lan Liao, Isha H. Jain, Diane E. Capen, Udbhav K. Chitta, Jayaraj Rajagopal, Robert M. H. Grange, Jianming Xu
Publikováno v:
Science. 371:52-57
Protecting the lung from hypoxic stress The lung experiences constantly changing oxygen concentrations and must recognize and respond to a low-oxygen environment. Shivaraju et al. reveal that airway stem cells directly sense hypoxia and respond by di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d057a21ed3c5754f9b3513acb4454f
https://doi.org/10.1126/science.aba0629
https://doi.org/10.1126/science.aba0629
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Robert M. H. Grange, Olga Goldberger, Eizo Marutani, Rohit Sharma, Michele Ferrari, Owen S. Skinner, Warren M. Zapol, Martin Wepler, Grigorij Schleifer, Kathryn M. Peneyra, Daniel Bloch, Fumito Ichinose, Rajeev Malhotra, Vamsi K. Mootha
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
Hypoxic pulmonary vasoconstriction (HPV) is a physiological vasomotor response that maintains systemic oxygenation by matching perfusion to ventilation during alveolar hypoxia. Although mitochondria appear to play an essential role in HPV, the impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acb8dccee94783d3a395cc14af31d4d
http://europepmc.org/articles/PMC6397345
http://europepmc.org/articles/PMC6397345
Autor:
Robert M H, Grange, Rohit, Sharma, Hardik, Shah, Bryn, Reinstadler, Olga, Goldberger, Marissa K, Cooper, Akito, Nakagawa, Yusuke, Miyazaki, Allyson G, Hindle, Annabelle J, Batten, Gregory R, Wojtkiewicz, Grigorij, Schleifer, Aranya, Bagchi, Eizo, Marutani, Rajeev, Malhotra, Donald B, Bloch, Fumito, Ichinose, Vamsi K, Mootha, Warren M, Zapol
Publikováno v:
Mol Genet Metab
Leigh syndrome is a severe mitochondrial neurodegenerative disease with no effective treatment. In the Ndufs4(−/−) mouse model of LS, continuously breathing 11% O(2) (hypoxia) prevents neurodegeneration and leads to a dramatic extension (~5-fold)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0267752dcaa19019458cf3a795f5b069
https://pubmed.ncbi.nlm.nih.gov/33752971
https://pubmed.ncbi.nlm.nih.gov/33752971