Zobrazeno 1 - 10
of 1 218
pro vyhledávání: '"H. Gouveia"'
Autor:
Ayo P. Doumatey, Daniel Shriner, Jie Zhou, Lin Lei, Guanjie Chen, Omolara Oluwasola-Taiwo, Susan Nkem, Adela Ogundeji, Sally N. Adebamowo, Amy R. Bentley, Mateus H. Gouveia, Karlijn A. C. Meeks, Clement A. Adebamowo, Adebowale A. Adeyemo, Charles N. Rotimi
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background Type 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the pathophysiology of T2D remain scarce outside Europe and North America. The aims of this study are t
Externí odkaz:
https://doaj.org/article/4d020d773e6245dab0caa4b6f73e88be
Autor:
Zhiwei Liu, Yang Luo, Samuel Kirimunda, Murielle Verboom, Olusegun O. Onabajo, Mateus H. Gouveia, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Isaac Otim, Ismail D. Legason, Hadijah Nabalende, Herry Dhudha, Leona W. Ayers, Kishor Bhatia, James J. Goedert, Nathan Cole, Wen Luo, Jia Liu, Michelle Manning, Belynda Hicks, Ludmila Prokunina-Olsson, George Chagaluka, W. Thomas Johnston, Nora Mutalima, Eric Borgstein, George N. Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth M. Molyneux, Robert Newton, Ann W. Hsing, James E. Mensah, Anthony A. Adjei, Amy Hutchinson, Mary Carrington, Meredith Yeager, Rainer Blasczyk, Stephen J. Chanock, Soumya Raychaudhuri, Sam M. Mbulaiteye
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Burkitt lymphoma (BL) is responsible for many childhood cancers in sub-Saharan Africa, where it is linked to recurrent or chronic infection by Epstein-Barr virus or Plasmodium falciparum. However, whether human leukocyte antigen (HLA) polymo
Externí odkaz:
https://doaj.org/article/9dbb6d4ddc894347a08013feb54d1c14
Autor:
Weiyin Zhou, Anja Fischer, Martin D. Ogwang, Wen Luo, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Isaac Otim, Ismail D. Legason, Hadijah Nabalende, Leona W. Ayers, Kishor Bhatia, James J. Goedert, Mateus H. Gouveia, Nathan Cole, Belynda Hicks, Kristine Jones, Michael Hummel, Mathias Schlesner, George Chagaluka, Nora Mutalima, Eric Borgstein, George N. Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth M. Molyneux, Robert Newton, Selina Glaser, Helene Kretzmer, Michelle Manning, Amy Hutchinson, Ann W. Hsing, Yao Tettey, Andrew A. Adjei, Stephen J. Chanock, Reiner Siebert, Meredith Yeager, Ludmila Prokunina-Olsson, Mitchell J. Machiela, Sam M. Mbulaiteye
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosaic chromosomal alterations in sub
Externí odkaz:
https://doaj.org/article/d757f218f82541a7abe121d8c91e7678
Autor:
Mateus H. Gouveia, Amy R. Bentley, Thiago P. Leal, Eduardo Tarazona-Santos, Carlos D. Bustamante, Adebowale A. Adeyemo, Charles N. Rotimi, Daniel Shriner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract European-ancestry populations are recognized as stratified but not as admixed, implying that residual confounding by locus-specific ancestry can affect studies of association, polygenic adaptation, and polygenic risk scores. We integrate ind
Externí odkaz:
https://doaj.org/article/da41646993fe42cfb788b74e956585d3
Autor:
Odessica Hughes, Amy R. Bentley, Charles E. Breeze, Francois Aguet, Xiaoguang Xu, Girish Nadkarni, Quan Sun, Bridget M. Lin, Thomas Gilliland, Mariah C. Meyer, Jiawen Du, Laura M. Raffield, Holly Kramer, Robert W. Morton, Mateus H. Gouveia, Elizabeth G. Atkinson, Adan Valladares-Salgado, Niels Wacher-Rodarte, Nicole D. Dueker, Xiuqing Guo, Yang Hai, Adebowale Adeyemo, Lyle G. Best, Jianwen Cai, Guanjie Chen, Michael Chong, Ayo Doumatey, James Eales, Mark O. Goodarzi, Eli Ipp, Marguerite Ryan Irvin, Minzhi Jiang, Alana C. Jones, Charles Kooperberg, Jose E. Krieger, Ethan M. Lange, Matthew B. Lanktree, James P. Lash, Paulo A. Lotufo, Ruth J.F. Loos, Vy Thi Ha My, Jesús Peralta-Romero, Lihong Qi, Leslie J. Raffel, Stephen S. Rich, Erik J. Rodriquez, Eduardo Tarazona-Santos, Kent D. Taylor, Jason G. Umans, Jia Wen, Bessie A. Young, Zhi Yu, Ying Zhang, Yii-Der Ida Chen, Tanja Rundek, Jerome I. Rotter, Miguel Cruz, Myriam Fornage, Maria Fernanda Lima-Costa, Alexandre C. Pereira, Guillaume Paré, Pradeep Natarajan, Shelley A. Cole, April P. Carson, Leslie A. Lange, Yun Li, Eliseo J. Perez-Stable, Ron Do, Fadi J. Charchar, Maciej Tomaszewski, Josyf C. Mychaleckyj, Charles Rotimi, Andrew P. Morris, Nora Franceschini
Publikováno v:
Cell Genomics, Vol 4, Iss 1, Pp 100468- (2024)
Summary: Chronic kidney disease is a leading cause of death and disability globally and impacts individuals of African ancestry (AFR) or with ancestry in the Americas (AMS) who are under-represented in genome-wide association studies (GWASs) of kidne
Externí odkaz:
https://doaj.org/article/975974e930614de28f7b1b95b70b9859
Autor:
Daniel Shriner, Amy R. Bentley, Mateus H. Gouveia, Elisabeth F. Heuston, Ayo P. Doumatey, Guanjie Chen, Jie Zhou, Adebowale Adeyemo, Charles N. Rotimi
Publikováno v:
HGG Advances, Vol 4, Iss 4, Pp 100235- (2023)
Summary: The vast majority of human populations and individuals have mixed ancestry. Consequently, adjustment for locus-specific ancestry is essential for genetic association studies. To empower association studies for all populations, it is necessar
Externí odkaz:
https://doaj.org/article/1614d4c036784e4f84fb1f27ae97ccf9
Autor:
Karlijn A. C. Meeks, Amy R. Bentley, Mateus H. Gouveia, Guanjie Chen, Jie Zhou, Lin Lei, Adebowale A. Adeyemo, Ayo P. Doumatey, Charles N. Rotimi
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-21 (2021)
Abstract Background A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of these cytokines and hor
Externí odkaz:
https://doaj.org/article/9015e7a80c73457f9ceaac5065245fca
Autor:
Mateus H. Gouveia, Amy R. Bentley, Hampton Leonard, Karlijn A. C. Meeks, Kenneth Ekoru, Guanjie Chen, Michael A. Nalls, Eleanor M. Simonsick, Eduardo Tarazona-Santos, Maria Fernanda Lima-Costa, Adebowale Adeyemo, Daniel Shriner, Charles N. Rotimi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and tra
Externí odkaz:
https://doaj.org/article/0053a1ca207d4af1a4a039816eafa93f
Publikováno v:
Revista Brasileira de Educação Médica, Vol 43, Iss 1 suppl 1, Pp 82-90 (2020)
RESUMO O reconhecimento das características culturais dos grupos sociais e de suas diferentes necessidades e concepções do processo saúde-doença, segundo Starfield, é um importante atributo derivado da atenção primária: a competência cultur
Externí odkaz:
https://doaj.org/article/12166bfa077c45f18bac7930b95d060e
Autor:
André L S Zani, Mateus H Gouveia, Marla M Aquino, Rodrigo Quevedo, Rodrigo L Menezes, Charles Rotimi, Gerald O Lwande, Collins Ouma, Ephrem Mekonnen, Nelson J R Fagundes
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0265625 (2022)
Since the 1960s, East African athletes, mainly from Kenya and Ethiopia, have dominated long-distance running events in both the male and female categories. Further demographic studies have shown that two ethnic groups are overrepresented among elite
Externí odkaz:
https://doaj.org/article/f40b892b91fc4bfd8df79ea8584350ff