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A Journey from Roots to Bulk Soil: Organic Matter Characterization in the Biosphere 2 Tropical Rainforest

Autor: R. Cruz Pérez, H. Gieschen, J. Fudyma, Laura Meredith, M. M. Tfaily, Roya AminiTabrizi, T. Chee

The Biosphere 2 (B2) is a large-scale research facility owned by the University of Arizona that comprises seven enclosed biomes. Among these is the Tropical Rainforest (TRF), where environmental fa...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::787fb364d595b0a9d9727597a4242887
https://doi.org/10.1002/essoar.10502104.1

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Untargeted metabolomic profiling of Sphagnum fallax reveals novel antimicrobial metabolites

Autor: David W. Hoyt, J. Fudyma, Jason Toyoda, Rosalie K. Chu, H. Gieschen, Thomas O. Metz, Malak M. Tfaily, Jennifer E. Kyle, Nikola Tolić, Jamee Lyon, Roya AminiTabrizi, Heino M. Heyman, Nancy J. Hess

Publikováno v: Plant Direct, Vol 3, Iss 11, Pp n/a-n/a (2019)

Sphagnum mosses dominate peatlands by employing harsh ecosystem tactics to prevent vascular plant growth and microbial degradation of these large carbon stores. Knowledge about Sphagnum‐produced metabolites, their structure and their function, is i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c70f16cb283c94861d65eeda0593680
https://doi.org/10.1002/pld3.179

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In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development

Autor: Kerstin Julia Schäfer, N. Mathias, A. Reichel, H. Gieschen, A. Rotgeri, P. Zane, A. Van den Bergh, S. Van Hemelryck, Céline Ollier, P. Johansson, Anette Müllertz, E. Kersten, Peter Langguth

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142

The ability to predict new chemical entity performance using in vivo animal models has been under investigation for more than two decades. Pharmaceutical companies use their own strategies to make decisions on the most appropriate formulation startin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ea2a9621bf181bcf89c44720da1b05
https://pubmed.ncbi.nlm.nih.gov/31233862

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Predicting the oral bioavailability of 19-nortestosterone progestins in vivo from their metabolic stability in human liver microsomal preparations in vitro

Autor: W, Kuhnz, H, Gieschen

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 26(11)

It was the aim of this study to investigate whether assessment of the metabolic stability of selected progestins of the 19-nortestosterone type in human microsomal liver preparations was a suitable approach to predict the oral bioavailability of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a29e1f3509fad5993f953289e8693d0
https://pubmed.ncbi.nlm.nih.gov/9806955

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Akademický článek

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Xenobiotic Metabolism: From Intact Biosystem to Single Enzymes

Autor: M. Hümpel, H. Gieschen, C. Kraus, M. Hildebrand

Publikováno v: Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research ISBN: 9783662030219

The evolutionary process has yielded an endogenous system in living organisms that is able to transform and functionalize compounds for life requirements, deactivate them in the postfunctional phase, and thus provide the equipment for handling endo-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d4910556d3431e9903bc8eaadf2f9d3
https://doi.org/10.1007/978-3-662-03019-6_1

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