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Sex- and Enantiospecific Differences in the Formation Rate of Hydroxyeicosatetraenoic Acids in Rat Organs

Autor: Samar H Gerges, Ahmad H. Alammari, Mahmoud A. El-Ghiaty, Fadumo A. Isse, Ayman OS El-Kadi

Publikováno v: Canadian Journal of Physiology and Pharmacology.

Hydroxyeicosatetraenoic acids (HETEs) are hydroxylated arachidonic acid (AA) metabolites that are classified into midchain, subterminal, and terminal HETEs. Hydroxylation results in the formation of R and S enantiomers for each HETE, except for 20-HE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f51ce7385444a1f70e4eacdfc24806c
https://doi.org/10.1139/cjpp-2023-0014

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Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review

Autor: Doaa A. Elsherbiny, Samar H. Gerges, Sara A. Wahdan, Ebtehal El-Demerdash

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 47:1-18

Flavonoids are phytochemicals that are well known for their beneficial pharmacological properties. Diosmin is a flavone glycoside derived from hesperidin, a flavanone abundantly found in citrus fruits. Daflon is an oral phlebotonic flavonoid combinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8224fde607e6e26e6b42d3ce9ec7668a
https://doi.org/10.1007/s13318-021-00731-y

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6-Formylindolo[3,2-b]carbazole (FICZ) protects against angiotensin II-inducedcellular hypertrophy through the induction of CYP1A1 and its associated 19(S)-HETE metabolite invitro

Autor: Ahmad H. Alammari, Samar H. Gerges, Fadumo Ahmed Isse, Ayman O.S. El-Kadi

Publikováno v: Drug Metabolism and Disposition. :DMD-AR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80ef80ce40338d0d2bf4fe448dd5b286
https://doi.org/10.1124/dmd.123.001267

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Sexual Dimorphism in the Expression of Cytochrome P450 Enzymes in Rat Heart, Liver, Kidney, Lung, Brain, and Small Intestine

Autor: Samar H. Gerges, Ayman O.S. El-Kadi

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 51(1)

Cytochrome P450 (P450) enzymes are monooxygenases that are expressed hepatically and extrahepatically and play an essential role in xenobiotic metabolism. Substantial scientific evidence indicates sex-specific differences between males and females in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd07d30fec631c2734706590d7aef166
https://pubmed.ncbi.nlm.nih.gov/36116791

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Non-alcoholic fatty liver disease: An overview of risk factors, pathophysiological mechanisms, diagnostic procedures, and therapeutic interventions

Autor: Sara A. Wahdan, Doaa A. Elsherbiny, Samar H. Gerges, Ebtehal El-Demerdash

Publikováno v: Life sciences. 271

Non-alcoholic fatty liver disease (NAFLD) is a disorder of excessive fat accumulation in the liver, known as steatosis, without alcohol overconsumption. NAFLD can either manifest as simple steatosis or steatohepatitis, known as non-alcoholic steatohe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa12a3c308b229c0aabc83c8cb34fe9
https://pubmed.ncbi.nlm.nih.gov/33592199

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Smarter and Greener Design and Operation of Primary Sedimentation Tanks Using Three-Dimensional Computational Fluid Dynamic Modeling

Autor: L S Tam, M Chan, H Gerges, D Tang, K M Ho, D Law

Publikováno v: Proceedings of the Water Environment Federation. 2018:122-132

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c640a3668eb2de2c0e302585d68d7532
https://doi.org/10.2175/193864718825138088

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EFFECT OF DSS ADMINISTRATION AND SULFASALAZINE TREATMENT ON BODY WEIGHT AND OXIDATIVE STRESS IN EXPERIMENTAL ULCERATIVE COLITIS IN MICE

Autor: Samar H. Gerges

Publikováno v: Al-Azhar Journal of Pharmaceutical Sciences. 55:97-108

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), characterized by chronic inflammation of the gastrointestinal tract. In general, IBD is more common in Western than in Eastern places, and in industrialized than in developing cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f3feeaf75598f21d9671d820b2b1122
https://doi.org/10.21608/ajps.2017.28409

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The natural flavonoid galangin ameliorates dextran sulphate sodium-induced ulcerative colitis in mice: Effect on Toll-like receptor 4, inflammation and oxidative stress

Autor: Doaa A. Elsherbiny, Samar H. Gerges, Mai F. Tolba, Ebtehal El-Demerdash

Publikováno v: Basicclinical pharmacologytoxicologyREFERENCES. 127(1)

This study was carried out to investigate the potential therapeutic effect of galangin, a promising active principle of honeybee propolis, in dextran sulphate sodium (DSS)-induced colitis in mice. We explored the possible underlying mechanisms for ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f1e1b2cb9ce8549ccb2d87eb11e0fd
https://pubmed.ncbi.nlm.nih.gov/31943791

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