Zobrazeno 1 - 10
of 16
pro vyhledávání: '"H. Garry Dallmann"'
Autor:
Junglim Lee, Charles S. McHenry, H. Garry Dallmann, Xuedong Liu, Dana Ungermannova, Gan Zhang
Publikováno v:
SLAS Discovery. 18:910-920
Decreased levels of cell cycle inhibitor p27(Kip1) due to excessive degradation occur in a variety of aggressive human tumors. Since reduced p27(Kip1) expression has been associated with a poor prognosis in many human cancers and resistance to certai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79e9041dfb74d3ce9594551b8d51262
https://doi.org/10.1177/1087057113485789
https://doi.org/10.1177/1087057113485789
Publikováno v:
Journal of Biological Chemistry. 285:29049-29053
The DnaX complex (DnaX(3)δδ'χ psi) within the Escherichia coli DNA polymerase III holoenzyme serves to load the dimeric sliding clamp processivity factor, β(2), onto DNA. The complex contains three DnaX subunits, which occur in two forms: τ and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4336dbdb791f0e2186d2456b783007a
https://doi.org/10.1074/jbc.c110.165076
https://doi.org/10.1074/jbc.c110.165076
Autor:
Charles S. McHenry, Marcos T. Oliveira, Laurie S. Kaguni, Oliver J. Fackelmayer, Casey Pope, Anna Wiktor-Becker, Peter M. J. Burgers, Joe Chen, Guy Tomer, Tracey M. Ferrara, H. Garry Dallmann
Publikováno v:
Biochemistry. 49:2551-2562
Typically, biochemical screens that employ pure macromolecular components focus on single targets or a small number of interacting components. Researches rely on whole cell screens for more complex systems. Bacterial DNA replicases contain multiple s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07df9ab8b0120d47ebb9f3ef2e2454f0
https://doi.org/10.1021/bi9020764
https://doi.org/10.1021/bi9020764
Autor:
Charles S. McHenry, James M. Bullard, Urs A. Ochsner, H. Garry Dallmann, Amber A. Beaudry, Thale C. Jarvis
Publikováno v:
Journal of Biological Chemistry. 280:40465-40473
We previously reconstituted a minimal DNA replicase from Pseudomonas aeruginosa consisting of alpha and epsilon (polymerase and editing nuclease), beta (processivity factor), and the essential tau, delta, and delta' components of the clamp loader com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1edaa533f77310825270a033c2afd7
https://doi.org/10.1074/jbc.m508310200
https://doi.org/10.1074/jbc.m508310200
Publikováno v:
Journal of Biological Chemistry. 275:15512-15519
A contact between the dimeric tau subunit within the DNA polymerase III holoenzyme and the DnaB helicase is required for replication fork propagation at physiologically-relevant rates (Kim, S., Dallmann, H. G., McHenry, C. S., and Marians, K. J. (199
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65a40911adad8a8a9a30e7b92a8727cd
https://doi.org/10.1074/jbc.m909257199
https://doi.org/10.1074/jbc.m909257199
Autor:
H. Garry Dallmann, Deshui Zhang, Ning Huang, Bradford A. Youngblood, Randall Alfano, Steve C. Pettit, Clinton C. MacDonald
Embryonic and induced pluripotent stem cells have the ability to differentiate into any somatic cell type, and thus have potential to treat a number of diseases that are currently incurable. Application of these cells for clinical or industrial uses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f5c26b4ef972374801d03a95bfdc88
https://europepmc.org/articles/PMC3947499/
https://europepmc.org/articles/PMC3947499/
Publikováno v:
Journal of Biological Chemistry. 271:10291-10298
A plasmid was constructed that encodes all five subunits of the Escherichia coli -complex on a single artificially constructed operon under the control of an inducible promoter. The proteins , , ′, , and overproduced from this artificial operon ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::064b8c55823b7e0c3392bd5efce15021
https://doi.org/10.1074/jbc.271.17.10291
https://doi.org/10.1074/jbc.271.17.10291
Publikováno v:
Molecular cell. 37(2)
Summary We have expressed and purified 13 proteins predicted to be required for B. subtilis DNA replication. When combined with a circular DNA template with a 5′ unpaired flap, these proteins reconstitute replication of both the leading and lagging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531ccf1ed6b86471db2303334c350c69
https://pubmed.ncbi.nlm.nih.gov/20122408
https://pubmed.ncbi.nlm.nih.gov/20122408
Autor:
Xicheng Sun, Jennifer Bertino, Kim Stone, Rob Sabin, Joseph Guiles, Charles S. McHenry, Frank B. Dean, Louis S. Green, Urs A. Ochsner, Ian A. Critchley, H. Garry Dallmann, Nebojsa Janjic, Ming Tregay
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
High throughput screening led to the discovery of a novel series of quinazolin-2-ylamino-quinazolin-4-ols as a new class of DNA polymerase III inhibitors. The inhibition of chromosomal DNA replication results in bacterial cell death. The synthesis, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d03d84eeedfc42f11d55317bc74560
https://pubmed.ncbi.nlm.nih.gov/19109016
https://pubmed.ncbi.nlm.nih.gov/19109016
Publikováno v:
The Journal of biological chemistry. 276(44)
The delta and delta' subunits are essential components of the DNA polymerase III holoenzyme, required for assembly and function of the DnaX-complex clamp loader (tau2gammadeltadelta'chipsi). The x-ray crystal structure of delta' contains three struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb51dfa4b02a976febf2319a8507eda
https://pubmed.ncbi.nlm.nih.gov/11518714
https://pubmed.ncbi.nlm.nih.gov/11518714