Zobrazeno 1 - 10
of 27
pro vyhledávání: '"H. G. Ramjit"'
Publikováno v:
Rapid Communications in Mass Spectrometry. 14:1368-1376
Harnessing the ultra high resolution capabilities of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) and positive ion electrospray, we have demonstrated the significance and utility of cumulative mass defect high resolution mas
Publikováno v:
Rapid communications in mass spectrometry : RCM. 14(15)
Harnessing the ultra high resolution capabilities of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) and positive ion electrospray, we have demonstrated the significance and utility of cumulative mass defect high resolution mas
Autor:
S, Vickers, A D, Theoharides, B, Arison, S K, Balani, D, Cui, C A, Duncan, J D, Ellis, L M, Gorham, S L, Polsky, T, Prueksaritanont, H G, Ramjit, D E, Slaughter, K P, Vyas
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(11)
Tirofiban hydrochloride [L-tyrosine-N-(butylsulfonyl)-O-[4-(4-piperidinebutyl)] monohydrochloride, is a potent and specific fibrinogen receptor antagonist. Radiolabeled tirofiban was synthesized with either (3)H-label incorporated into the phenyl rin
Publikováno v:
Journal of mass spectrometry : JMS. 31(8)
A gas chromatographic/mass spectrometric procedure using single-ion monitoring and repetitive scanning was developed to characterize and determine methyl methanesulphonate (MMS) and ethyl methanesulphonate (EMS) in the free base and bismesylate salt
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(2)
L-689,502, N-[2(R)-hydroxy-1(S)-indanyl]-5(S)-(1,1-dimethylethoxy- carbonyl-amino)-4(S)-hydroxy-6-phenyl-2(R)-(4-[2(R)-(4-morpholinyl) ethoxy]phenyl)methylhexamide, is a potent and specific inhibitor of human immunodeficiency virus-type 1 (HIV-1) pro
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 22(6)
Spironolactone (SP) is used clinically as a renal aldosterone antagonist and as an antiandrogen. It is known that the drug is extensively metabolized and that metabolites mediate its therapeutic actions, but hepatic metabolism of SP has not been comp
Autor:
S K, Balani, L R, Kauffman, B H, Arison, T V, Olah, M E, Goldman, S L, Varga, J A, O'Brien, H G, Ramjit, C S, Rooney, J M, Hoffman
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 22(2)
Healthy subjects were administered single oral doses of 800 mg or 400 mg 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-o ne (L-696,229), a nonnucleoside inhibitor of the human immunodeficiency virus-type 1 (HIV-1) reverse transcriptase (
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(6)
Spironolactone (SL) is a renal aldosterone antagonist that is used clinically in the treatment of hypertension and congestive heart failure. Among the side effects of the drug are degradation of cytochrome P-450 and inhibition of steroidogenesis in t
Autor:
S K, Balani, M E, Goldman, L R, Kauffman, S L, Varga, J A, O'Brien, S J, Smith, T V, Olah, H G, Ramjit, T W, Schorn, S M, Pitzenberger
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(4)
Rhesus monkeys were dosed orally with 10 mg/kg 5-chloro-3-phenylthioindole-2-carboxamide (L-734,005), a nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor, in polyethylene glycol 300. Plasma samples from these m
Publikováno v:
Biological mass spectrometry. 22(1)
A general method for the assay of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors lovastatin, pravastatin, and simvastatin in plasma has been developed and validated. The analytes are isolated from plasma by a solid-phase ext