Zobrazeno 1 - 10
of 59
pro vyhledávání: '"H. G. Klobeck"'
Autor:
H G Klobeck, H Asenbauer
Publikováno v:
European Journal of Immunology. 26:142-150
During B cell development, the onset of DNA rearrangements, expression, and somatic hypermutation of Ig genes are regulated through the complex interaction of cis-acting elements with trans-acting factors. Our aim is to identify DNA elements required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6197526f5938bebc1df2c2025ad2c10
https://doi.org/10.1002/eji.1830260122
https://doi.org/10.1002/eji.1830260122
Publikováno v:
European Journal of Immunology. 22:1561-1565
V kappa genes of man can recombine with the J kappa gene segments either by an inversion or by a deletion mechanism. Back-to-back fusion products of the respective recombination signal sequences (signal joints) are retained on the chromosome after th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebd6b227122d8bb64dc14cb2cc4625a0
https://doi.org/10.1002/eji.1830220632
https://doi.org/10.1002/eji.1830220632
Autor:
K, Kawasaki, S, Minoshima, E, Nakato, K, Shibuya, A, Shintani, S, Asakawa, T, Sasaki, H G, Klobeck, G, Combriato, H G, Zachau, N, Shimizu
Publikováno v:
European journal of immunology. 31(4)
We have determined the entire nucleotide sequence of the human immunoglobulin kappa locus, comprising a total of 1,010,706 nucleotides. The 76 Vkappa genes found by a hybridization-based approach and their classification in 7 families were confirmed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1bcea08beca1e90d365bb76f2308be26
https://pubmed.ncbi.nlm.nih.gov/11298326
https://pubmed.ncbi.nlm.nih.gov/11298326
Publikováno v:
European journal of immunology. 29(2)
V(D)J rearrangement, high level expression and somatic hypermutation of assembled Ig genes is tightly controlled by a number of regulatory sequence elements located in the vicinity of the J-, (D)-, and C-gene segments. During B cell maturation these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9e947e71ba10d4cc16231df16f3172e
https://pubmed.ncbi.nlm.nih.gov/10064089
https://pubmed.ncbi.nlm.nih.gov/10064089
Autor:
M, Yamaguchi, T, Machii, H, Shibayama, Y, Tokumine, J, Hara, M, Yutsudo, O, Yamada, H G, Klobeck, T, Kitani
Publikováno v:
Leukemia. 10(8)
Immunophenotypes and Ig gene rearrangements were investigated in 12 patients with a variant form of hairy cell leukemia (HCL) termed HCL-Japanese variant (HCL-J), and in an HCL-J-derived cell line. The leukemic cells of HCL-J characteristically showe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96040fb482250b95dbf87dd67078848a
https://pubmed.ncbi.nlm.nih.gov/8709650
https://pubmed.ncbi.nlm.nih.gov/8709650
Publikováno v:
Genomics. 30(2)
H3.3 is a replacement histone subtype that is encoded by two replication-independent genes termed H3.3A and H3.3B, respectively. We have isolated a full-size H3.3 cDNA clone from an oligo(dT)-primed human testicular cDNA library. Subsequently, the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee98c03fcf1fb55f22ac8395bfcee66
https://pubmed.ncbi.nlm.nih.gov/8586426
https://pubmed.ncbi.nlm.nih.gov/8586426
Publikováno v:
European journal of immunology. 25(11)
The immunoglobulin heavy chain 3' enhancer may be a novel type of a transcriptional regulation element in as much as its function is position dependent. We show that there are interactions between the mu intron and 3' enhancer which are differentiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15d1053a2db95bb59963728daeb803b
https://pubmed.ncbi.nlm.nih.gov/7489764
https://pubmed.ncbi.nlm.nih.gov/7489764
Publikováno v:
European journal of immunology. 22(6)
V kappa genes of man can recombine with the J kappa gene segments either by an inversion or by a deletion mechanism. Back-to-back fusion products of the respective recombination signal sequences (signal joints) are retained on the chromosome after th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::274aefbd4bc783dde1c4e6d81f2d46d9
https://pubmed.ncbi.nlm.nih.gov/1601042
https://pubmed.ncbi.nlm.nih.gov/1601042
Autor:
G, Combriato, H G, Klobeck
Publikováno v:
European journal of immunology. 21(6)
We have cloned a region of 124 kb of the human immunoglobulin lambda light chain locus on chromosome 22 encompassing seven V lambda and seven J-C lambda gene segments. No further C lambda gene segment was found in a region of 35 kb downstream of C la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::072a10d513c5ba7f864c1961b41b01f4
https://pubmed.ncbi.nlm.nih.gov/1904362
https://pubmed.ncbi.nlm.nih.gov/1904362
Publikováno v:
Nature. 347(6288)
The genes of the immunoglobulin kappa light chains are assembled during B-cell differentiation by somatic recombination of one of the V kappa (variable) gene segments and the J kappa-C kappa (joining-constant) gene region. This seems to occur by dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49ba6d3766278af32516cca961dd103
https://pubmed.ncbi.nlm.nih.gov/2118596
https://pubmed.ncbi.nlm.nih.gov/2118596