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Safety and efficacy of faecal microbiota transplantation by Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis: study protocol for the randomised controlled phase II ReSScue trial

Autor: Gunnstein Bakland, Elizabeth R Volkmann, Dinesh Khanna, Oliver Distler, Anna-Maria Hoffmann-Vold, Øyvind Midtvedt, Øyvind Molberg, Alvilde Dhainaut, Vikas K Sarna, Håvard H Fretheim, Imon Barua, Maylen N Carstens, Henriette Didriksen, Anne-Kristine Halse, Maiju Pesonen, Inge Olsen

Publikováno v: BMJ Open, Vol 11, Iss 6 (2021)

Introduction In the multisystem inflammatory disorder systemic sclerosis (SSc), gastrointestinal tract (GIT) affliction is highly prevalent. There are no known disease modifying therapies and the negative impact is substantial. Aiming for a new thera

Externí odkaz: https://doaj.org/article/da9f8b1d4122456db6b1e883d2e677c3

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POS0870 PATIENTS WITH SYSTEMIC SCLEROSIS HAVE IMPAIRED FORCED VITAL CAPACITY, EVEN IN THE ABSENCE OF INTERSTITIAL LUNG DISEASE

Autor: H. Fretheim, I. Barua, Ø. Midtvedt, T. Garen, P. P. Diep, M. Durheim, C. Brunborg, A. M. Hoffmann-Vold

Publikováno v: Annals of the Rheumatic Diseases. 81:729.2-730

BackgroundSpirometry, in particular forced vital capacity (FVC), is a widely implemented tool in the initial diagnostic workup and monitoring of systemic sclerosis-related interstitial lung disease (SSc-ILD). In addition to ILD, several other extra-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::066ac659d75f5fc399a20606338559af
https://doi.org/10.1136/annrheumdis-2022-eular.1932

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POS0065 INTERSTITIAL LUNG DISEASE ASSOCIATED WITH PRIMARY SJÖGREN’S SYNDROME IS FREQUENTLY PROGRESSIVE

Autor: A. M. Hoffmann-Vold, H. Fretheim, P. P. Diep, K. Lerang, H. Andersson, Ø. Midtvedt, T. Garen, M. Durheim, T. M. Aaløkken, Ø. Palm, Ø. Molberg

Publikováno v: Annals of the Rheumatic Diseases. 81:249.3-249

BackgroundInterstitial lung disease (ILD) in primary Sjögren’s syndrome (pSS) has been reported to be present in 10-15% of patients, but pSS-ILD behavior over time is not well characterized.ObjectivesAssess the pattern of ILD in pSS, its disease b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9dcb047ff40b1026bcb93364d1dd386a
https://doi.org/10.1136/annrheumdis-2022-eular.4062

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POS0925 HIGH LEVELS OF BOTH CCL2 AND CCL17 WERE ASSOCIATED WITH MORE SEVERE SSc-ILD

Autor: I. Barua, V. Palchevskiy, H. Fretheim, H. Didriksen, T. Garen, T. M. Aaløkken, S. S. Weigt, Ø. Molberg, J. Belperio, A. M. Hoffmann-Vold

Publikováno v: Annals of the Rheumatic Diseases. 81:762.1-762

BackgroundSystemic sclerosis (SSc) carries a high risk for progressive interstitial lung disease (ILD). Several anti-inflammatory therapies have been used to treat SSc-ILD and recently the first antifibrotic therapy has been approved. Personalized tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fade6c6e90d509d818625856bda5cff
https://doi.org/10.1136/annrheumdis-2022-eular.5231

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POS0880 CHARACTERISTICS AND DISEASE COURSE OF UNTREATED PATIENTS WITH INTERSTITIAL LUNG DISEASE ASSOCIATED WITH SYSTEMIC SCLEROSIS

Autor: M. Scheidegger, A. Garaiman, C. Mihai, M. O. Becker, R. Dobrota, C. Bruni, S. Jordan, H. Fretheim, Ø. Midtvedt, H. J. Bjørkekjær, I. Barua, A. M. Hoffmann-Vold, O. Distler, M. Elhai

Publikováno v: Annals of the Rheumatic Diseases. 81:735.2-736

BackgroundInterstitial lung disease (ILD) is the leading cause of death in systemic sclerosis (SSc). European consensus guidelines consider that some patients with mild disease might not need pharmacological treatment (1). Up to now, the disease char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8af24e4e8220a685eab588311dae450d
https://doi.org/10.1136/annrheumdis-2022-eular.2495

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