Zobrazeno 1 - 10
of 126
pro vyhledávání: '"H. Forest"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Alzheimer’s disease (AD) is the most common cause of dementia in the aging population. Evidence implicates elevated soluble oligomeric Aβ as one of the primary triggers during the prodromic phase leading to AD, effected largely via hyperphosphoryl
Externí odkaz:
https://doaj.org/article/d5678f620a5f43a58cfbdfdebcab6564
Akademický článek
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Autor:
Robert A. Nichols, Kelly H. Forest
Publikováno v:
Trends in Molecular Medicine. 25:685-695
Alzheimer's disease (AD) is a relentlessly progressive neurodegenerative disease, currently incurable, which presents one of the largest unmet needs in medicine. AD is histologically characterized by the accumulation of extracellular amyloid-beta (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b8eef4da5f541376042c91d30251fd
https://doi.org/10.1016/j.molmed.2019.05.013
https://doi.org/10.1016/j.molmed.2019.05.013
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Alzheimer’s disease (AD) is the most common cause of dementia in the aging population. Evidence implicates elevated soluble oligomeric Aβ as one of the primary triggers during the prodromic phase leading to AD, effected largely via hyperphosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc8bb1a621237cf1cd179314778339d
https://pubmed.ncbi.nlm.nih.gov/33912008
https://pubmed.ncbi.nlm.nih.gov/33912008
Autor:
Yingui Li, Kelly H. Forest, Xiaoqin Tan, Lang Yi, Yingkun Zhi, Yan Dong, Robert A. Nichols, Qing X. Li, Shasha Bai, Zhibin Liang
Publikováno v:
Behavioural brain research. 398
β-Amyloid (Aβ) elevation, tau hyperphosphorylation, and neuroinflammation are major hallmarks of Alzheimer's disease (AD). Glycogen synthase kinase-3β (GSK-3β) is a key protein kinase implicated in the pathogenesis of AD. Blockade of GSK-3β is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f9578ec20cea82b61ac1b0011c06a4
https://pubmed.ncbi.nlm.nih.gov/33069740
https://pubmed.ncbi.nlm.nih.gov/33069740
Alzheimer’s disease (AD) is the most common cause of dementia in the aging population. Evidence implicates elevated soluble oligomeric Aβ as one of the primary triggers during the prodromic phase leading to AD, effected largely via hyperphosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2c628195d6c136b6fcb79efb758b5b
Autor:
Marco Bianchi, Haining Yang, Andrea Napolitano, Sandra Pastorino, Giovanni Gaudino, Ian Pagano, Laura Pellegrini, Zeyana Salim Saad-Jube, Vishal Singh Negi, David Larson, Harvey I. Pass, Michele Carbone, Sandro Jube, Jiaming Xue, Kelly H. Forest, Paul Morris
Publikováno v:
Oncotarget
// Laura Pellegrini 1 , Jiaming Xue 1, 3 , David Larson 1 , Sandra Pastorino 1 , Sandro Jube 2 , Kelly H. Forest 3 , Zeyana Salim Saad-Jube 4 , Andrea Napolitano 1, 5 , Ian Pagano 1 , Vishal S. Negi 5 , Marco E. Bianchi 6 , Paul Morris 7 , Harvey I.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966f875d4c636c9f258e23f199f0c30a
http://europepmc.org/articles/PMC5410252
http://europepmc.org/articles/PMC5410252
Autor:
Gianpietro Cagnoli, Laurent Pinard, Lorenzo Mereni, Matthieu Coulon, M. Granata, D. H. Forest, B. Sassolas, Jerome Degallaix, Anthony A. Amato, Julien Teillon, Christophe Michel
Publikováno v:
Appl.Opt.
Appl.Opt., 2020, 59 (5), pp.A229-A235. ⟨10.1364/AO.377293⟩
Appl.Opt., 2020, 59 (5), pp.A229-A235. ⟨10.1364/AO.377293⟩
Coating thermal noise is a fundamental limit for precision experiments based on optical and quantum transducers. In this review, after a brief overview of the techniques for coating thermal noise measurements, we present the latest world-wide researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf014ae85a8418ca33e40f8e270d1ed0
https://doi.org/10.1364/oic.2019.fa.1
https://doi.org/10.1364/oic.2019.fa.1
Autor:
Robert A. Nichols, Cedomir Todorovic, Claire L. Standen, Morris Benveniste, Tessi Sherrin, Roger J. Davis, Michael Robles, Caroline Morel, Norman J. Kennedy, Naghum Alfulaij, Seda Avcioglu Barutcu, Kelly H. Forest, Ezekiel Carpenter-Hyland
The c-Jun N-terminal kinase (JNK) signal transduction pathway is implicated in learning and memory. Here, we examined the role of JNK activation mediated by the JNK-interacting protein 1 (JIP1) scaffold protein. We compared male wild-type mice with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ccae1b031a81a3916db76232256f9e
https://europepmc.org/articles/PMC5895995/
https://europepmc.org/articles/PMC5895995/
Autor:
Tessi Sherrin, Robert A. Nichols, Ruth Taketa, Cedomir Todorovic, Komal Arora, Ho Leung Ng, James L.M. Lawrence, Kelly H. Forest, Naghum Alfulaij, Victor J. Hruby, Gene T. Yoshikawa
Publikováno v:
Journal of neurochemistry. 144(2)
High levels (μM) of beta amyloid (Aβ) oligomers are known to trigger neurotoxic effects, leading to synaptic impairment, behavioral deficits, and apoptotic cell death. The hydrophobic C-terminal domain of Aβ, together with sequences critical for o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f996768b287f570f9b8211d7de4f3e3
https://pubmed.ncbi.nlm.nih.gov/29164616
https://pubmed.ncbi.nlm.nih.gov/29164616