Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis

Autor: Martin H Fabry, Federica A Falconio, Fadwa Joud, Emily K Lythgoe, Benjamin Czech, Gregory J Hannon

Publikováno v: eLife, Vol 10 (2021)

The PIWI-interacting RNA (piRNA) pathway controls transposon expression in animal germ cells, thereby ensuring genome stability over generations. In Drosophila, piRNAs are intergenerationally inherited through the maternal lineage, and this has demon

Externí odkaz: https://doaj.org/article/7e7170d8f1084fafbe6be2d2ba3fdcc1

Author response: Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis

Autor: Gregory J. Hannon, Martin H Fabry, Emily K Lythgoe, Benjamin Czech, Fadwa Joud, Federica A Falconio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2892861e7db2bc39cfae7825a4e6ba21
https://doi.org/10.7554/elife.68573.sa2

Treatment and survival of locally recurrent rectal cancer: A cross-sectional population study 15 years after the Dutch TME trial

Autor: Robin Detering, Eleonora G. Karthaus, Wernard A.A. Borstlap, Corrie A.M. Marijnen, Cornelis J.H. van de Velde, Willem A. Bemelman, Geerard L. Beets, Pieter J. Tanis, Arend G.J. Aalbers, A.G.J. Aalbers, Y. Acherman, G.D. Algie, B. Alting von Geusau, F. Amelung, T.S. Aukema, I.S. Bakker, S.A. Bartels, S. Basha, A.J.N.M. Bastiaansen, E. Belgers, W. Bleeker, J. Blok, R.J.I. Bosker, J.W. Bosmans, M.C. Boute, N.D. Bouvy, H. Bouwman, A. Brandt-Kerkhof, D.J. Brinkman, S. Bruin, E.R.J. Bruns, J.P.M. Burbach, J.W.A. Burger, C.J. Buskens, S. Clermonts, P.P.L.O. Coene, C. Compaan, E.C.J. Consten, T. Darbyshire, S.M.L. de Mik, E.J.R. de Graaf, I. de Groot, RJ de Vos tot Nederveen Cappel, J.H.W. de Wilt, J. van der Wolde, FC den Boer, J.W.T. Dekker, A. Demirkiran, M. Derkx-Hendriksen, F.R. Dijkstra, P. van Duijvendijk, M.S. Dunker, Q.E. Eijsbouts, H. Fabry, F. Ferenschild, J.W. Foppen, E.J.B. Furnee, M.F. Gerhards, P. Gerven, J.A.H. Gooszen, J.A. Govaert, W.M.U. Van Grevenstein, R. Haen, J.J. Harlaar, E. van der Harst, K. Havenga, J. Heemskerk, J.F. Heeren, B. Heijnen, P. Heres, C. Hoff, W. Hogendoorn, P. Hoogland, A. Huijbers, P. Janssen, A.C. Jongen, F.H. Jonker, E.G. Karthaus, A. Keijzer, J.M.A. Ketel, J. Klaase, F.W.H. Kloppenberg, M.E. Kool, R. Kortekaas, P.M. Kruyt, J.T. Kuiper, B. Lamme, J.F. Lange, T. Lettinga, D.J. Lips, F. Logeman, M.F. Lutke Holzik, E. Madsen, A. Mamound, C.C. Marres, I. Masselink, M. Meerdink, A.G. Menon, J.S. Mieog, D. Mierlo, G.D. Musters, G.A.P. Nieuwenhuijzen, P.A. Neijenhuis, J. Nonner, M. Oostdijk, S.J. Oosterling, P.M.P. Paul, K.C.M.J. Peeters, I.T.A. Pereboom, F. Polat, P. Poortman, M. Raber, B.M.M. Reiber, R.J. Renger, C.C. van Rossem, H.J. Rutten, A. Rutten, R. Schaapman, M. Scheer, L. Schoonderwoerd, N. Schouten, A.M. Schreuder, W.H. Schreurs, G.A. Simkens, G.D. Slooter, H.C.E. Sluijmer, N. Smakman, R. Smeenk, H.S. Snijders, D.J.A. Sonneveld, B. Spaansen, EJ Spillenaar Bilgen, E. Steller, W.H. Steup, C. Steur, E. Stortelder, J. Straatman, H.A. Swank, C. Sietses, H.A. Groen, HG ten Hoeve, WW ter Riele, I.M. Thorensen, B. Tip-Pluijm, B.R. Toorenvliet, L. Tseng, J.B. Tuynman, J. van Bastelaar, S.C. van Beek, A.W.H. van de Ven, M.A.J. van de Weijer, C. van den Berg, I. van den Bosch, J.D.W. van der Bilt, S.J. van der Hagen, R. van der Hul, G. van der Schelling, A. van der Spek, N. van der Wielen, E. van Duyn, C. van Eekelen, J.A. van Essen, K. van Gangelt, A.A.W. van Geloven, C. van Kessel, Y.T. van Loon, A. van Rijswijk, S.J. van Rooijen, T. van Sprundel, L. van Steensel, W.F. van Tets, H.L. van Westreenen, S. Veltkamp, T. Verhaak, P.M. Verheijen, L. Versluis-Ossenwaarde, S. Vijfhuize, W.J. Vles, S.C. Voeten, F.J. Vogelaar, W.W. Vrijland, E. Westerduin, M.E. Westerterp, M. Wetzel, K.P. Wevers, B. Wiering, C.D.M. Witjes, M.W. Wouters, S.T.K. Yauw, E.S. van der Zaag, E.C. Zeestraten, D.D.E. Zimmerman, T. Zwieten

Publikováno v: EJSO, 45(11), 2059-2069. ELSEVIER SCI LTD
European Journal of Surgical Oncology, 45, 2059-2069
European Journal of Surgical Oncology, 45, 11, pp. 2059-2069
Detering, R, Karthaus, E G, Borstlap, W A A, Marijnen, C A M, van de Velde, C J H, Bemelman, W A, Beets, G L, Tanis, P J, Aalbers, A G J & Dutch Snapshot Research Group 2019, ' Treatment and survival of locally recurrent rectal cancer: A cross-sectional population study 15 years after the Dutch TME trial ', European Journal of Surgical Oncology, vol. 45, no. 11, pp. 2059-2069 . https://doi.org/10.1016/j.ejso.2019.06.016
European Journal of Surgical Oncology, 45(11), 2059-2069. W.B. Saunders Ltd
European journal of surgical oncology, 45(11), 2059-2069. W.B. Saunders Ltd
EJSO-European Journal of Surgical Oncology, 45(11), 2059-2069. ELSEVIER SCI LTD

Introduction: Optimized treatment of primary rectal cancer might have influenced treatment characteristics and outcome of locally recurrent rectal cancer (LRRC). Subgroup analysis of the Dutch TME trial showed that preoperative radiotherapy (PRT) for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e2d69688958c42c2cea20515fc5e7e
https://hdl.handle.net/1887/122929

piRNA-guided co-transcriptional silencing coopts nuclear export factors

Autor: Gregory J. Hannon, Marzia Munafò, Benjamin Czech, Evelyn L Eastwood, Emma Kneuss, Ilaria Falciatori, Martin H Fabry, Federica A Falconio, Filippo Ciabrelli

Publikováno v: eLife
eLife, Vol 8 (2019)

The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal gonads. In Drosophila, piRNA-guided silencing is achieved, in part, via co-transcriptiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c7d37728304d3e95c16e71a534ee1d
https://doi.org/10.1101/611343

Omitting axillary lymph node dissection in sentinel node negative breast cancer patients is safe: A long term follow-up analysis

Autor: Hans Torrenga, Joost R. M. van der Sijp, Sybren L. Meijer, Paul J. van Diest, H. Fabry, Rik Pijpers

Publikováno v: Torrenga, H, Fabry, H F J, van der Sijp, J R M, van Diest, P J, Pijpers, H J & Meijer, S 2004, ' Omitting axillary lymph node dissection in sentinal node negative breast cancer patients is safe: A long term follow-up analysis ', Journal of Surgical Oncology, vol. 88, no. 1, pp. 4-7 . https://doi.org/10.1002/jso.20101
Journal of Surgical Oncology, 88(1), 4-7. Wiley-Liss Inc.

Purpose To evaluate the rate of axillary recurrences in sentinel node (SN) negative breast cancer patients without further axillary lymph node dissection (ALND). Patients and Methods Between October 1994 and November 1999, all SN negative breast canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aadcffba89dae2d13b3d10a11057b87
https://doi.org/10.1002/jso.20101