Towards bone-remodeling-on-a-chip: self-assembling 3D osteoblast-osteoclast coculture in a microfluidic chip

Autor: M.A.M. Vis, F. Zhao, E.S.R. Bodelier, C.M. Bood, J. Bulsink, M. van Doeselaar, H. Eslami Amirabadi, K. Ito, S. Hofmann

Healthy bone is maintained by the process of bone remodeling. An unbalance in this process can lead to pathologies such as osteoporosis which are often studied with animal models. However, data from animals have limited power in predicting the result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c52721c23d3670308ef5151715c10667
https://doi.org/10.1101/2023.03.11.532167

Characterizing the invasion of different breast cancer cell lines with distinct E-cadherin status in 3D using a microfluidic system

Autor: C.C. van Donkelaar, J. W. M. Martens, J.M.J. den Toonder, S. SahebAli, M. Tuerlings, A. Hollestelle, Regina Luttge, H. Eslami Amirabadi

Publikováno v: Biomedical Microdevices, 21(4):101. Kluwer Academic
Biomedical Microdevices
Biomedical Microdevices, 21(4):101. Kluwer Academic Publishers
Biomedical Microdevices, 4, 21

E-cadherin is a cell-cell adhesion protein that plays a prominent role in cancer invasion. Inactivation of E-cadherin in breast cancer can arise from gene promoter hypermethylation or genetic mutation. Depending on their E-cadherin status, breast can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba7f19377bb3daaefa401796628548d
https://research.tue.nl/en/publications/2822b09f-7f2c-4065-a5fc-7d8cd1e704b5

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