Výsledky vyhledávání - "H. Erlandsson-Harris"

The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury

Autor: C, Aulin, S, Larsson, T, Vogl, J, Roth, A, Åkesson, P, Swärd, R, Heinbäck, H, Erlandsson Harris, A, Struglics

Publikováno v: Osteoarthritis and Cartilage

Objective To compare the concentrations of high mobility group box 1 protein (HMGB1) and S100A8/A9 in synovial fluid between patients with knee injuries and osteoarthritis (OA), and knee healthy subjects. To investigate associations of alarmin levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb75e2e78cfe046bc5ac04550e51220
https://hdl.handle.net/11250/3032810

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Early stage blockade of the alarmin HMGB1 reduces cartilage destruction in experimental OA

Autor: C, Aulin, T, Lassacher, K, Palmblad, H, Erlandsson Harris

Publikováno v: Osteoarthritis and cartilage. 28(5)

The alarmin HMGB1 is an endogenous molecule that is released into the extracellular space upon trauma or cell activation. Extracellular HMGB1 initiates innate immune responses and besides mediating inflammation, has osteoclast-activating features and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b6b18460532f9fed27c0aa8cf249691
https://pubmed.ncbi.nlm.nih.gov/31982563

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An in vivo cross-linkable hyaluronan gel with inherent anti-inflammatory properties reduces OA cartilage destruction in female mice subjected to cruciate ligament transection

Autor: Karin Palmblad, H. Erlandsson Harris, Cecilia Aulin, Lars Klareskog, P. Lundbäck

Publikováno v: Osteoarthritis and cartilage. 25(1)

Summary Objective To explore the possibility of cartilage protection in osteoarthritis (OA) by intraarticular injection of a chemically modified hyaluronan (HA) gel and investigate whether the chemical modifications provide intrinsic anti-inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edf358ab54835a4713aba23af3b0028
https://pubmed.ncbi.nlm.nih.gov/27587077

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Suppressive effects of a quinoxaline-analogue (Rob 803) on pathogenic immune mechanisms in collagen-induced arthritis

Autor: H. Erlandsson Harris, D. D. Thi Ngoc, Lars Klareskog, E. Westman

Publikováno v: Clinical and Experimental Immunology. 152:192-199

Summary The anti-arthritic effects of the synthetic compound 9-chloro-2,3 dimethyl-6-(N,N-dimetylamino-2-oxoethyl)-6H-indolo[2,3-b] quinoxaline (Rob 803) was evaluated by treating Dark Agouti rats with collagen-induced arthritis using three different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc42401a1295bf7e54c3e80411594ba
https://doi.org/10.1111/j.1365-2249.2008.03613.x

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Arthritogenicity of collagen type II is increased by chlorination

Autor: H. Erlandsson Harris, E. Westman, Karin Lundberg

Publikováno v: Clinical and Experimental Immunology. 145:339-345

Summary During inflammation, activated neutrophils, monocytes and macrophages produce and release myeloperoxidase (MPO). MPO converts hydrogen peroxide to hypochlorous acid, a highly reactive and oxidizing agent. Proteins subjected to hypochlorous ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4967a75ff8ce496307b1eeb4e057ca
https://doi.org/10.1111/j.1365-2249.2006.03129.x

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Corticosteroid treatment of experimental arthritis retards cartilage destruction as determined by histology and serum COMP

Autor: Tore Saxne, Bengt Månsson, Ellen Larsson, Lars Klareskog, Anders Larsson, H. Erlandsson Harris

Publikováno v: Rheumatology. 43:428-434

Objective. To examine if changes in serum cartilage oligomeric matrix protein (COMP) correlate with the development of cartilage damage, as measured by histological grading, in corticosteroid-treated animals with collagen-induced arthritis (CIA). Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5806d57830c9a2de64996e242e38d041
https://doi.org/10.1093/rheumatology/keh073

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Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity

Autor: Karin Palmblad, Erik Sundberg, Huan Yang, Ann-Charlotte Aveberger, Ulf Andersson, R. Kokkola, Kevin J. Tracey, Jian Li, H. Erlandsson Harris

Publikováno v: Arthritis & Rheumatism. 48:2052-2058

Objective Extracellular high mobility group box chromosomal protein 1 (HMGB-1) is a recently identified, endogenous, potent tumor necrosis factor– and interleukin-1 (IL-1)–inducing protein detectable in inflamed synovia in both human and experime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edb5b306f780dc3d8c8fe12baac78eb
https://doi.org/10.1002/art.11161

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Antigen inhibition of collagen-induced arthritis is associated with up-regulation of IL-4 mRNA and induction of Ox40 on T cells in draining lymph nodes

Autor: A. Jansson, H. Erlandsson Harris, Karin Lundberg, E. Müssener, Per Larsson, L. Mattsson

Publikováno v: Karolinska Institutet

SUMMARYThe addition of a foreign antigen to an inoculum completely inhibits the development of collagen-induced arthritis (CIA). However, the mechanism of this phenomenon, antigen -inhibition, is incompletely understood. Previous studies have demonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0b0bcb450aee260879f0106c8850db
https://doi.org/10.1046/j.1365-2249.2003.02054.x

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