Zobrazeno 1 - 10
of 22
pro vyhledávání: '"H. Elizabeth Shick"'
Autor:
Angela M. Lager, Olivia G. Corradin, Jared M. Cregg, Matthew S. Elitt, H. Elizabeth Shick, Benjamin L. L. Clayton, Kevin C. Allan, Hannah E. Olsen, Mayur Madhavan, Paul J. Tesar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mo
Externí odkaz:
https://doaj.org/article/71dbdedc40fa404b962276780906a9a8
Autor:
Matthew S. Elitt, H. Elizabeth Shick, Mayur Madhavan, Kevin C. Allan, Benjamin L.L. Clayton, Chen Weng, Tyler E. Miller, Daniel C. Factor, Lilianne Barbar, Baraa S. Nawash, Zachary S. Nevin, Angela M. Lager, Yan Li, Fulai Jin, Drew J. Adams, Paul J. Tesar
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 711-726 (2018)
Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancem
Externí odkaz:
https://doaj.org/article/85ceab688bb44f7d8336a4d35cb11973
Autor:
Ryan M. Friedrich, Joel L. Sax, David Yan, Zita Hubler, Drew J. Adams, Ramya Srinivasan, Adrianna M. Rivera-León, Farrah Gao, Ilya Bederman, Matthew J. Pleshinger, Paul J. Tesar, H. Elizabeth Shick
Publikováno v:
RSC Chemical Biology
While the cholesterol biosynthesis pathway has been extensively studied, recent work has forged new links between inhibition of specific sterol pathway enzymes, accumulation of their unique sterol substrates, and biological areas as diverse as cancer
Autor:
Ronald A. Conlon, Berit Powers, Matthew S. Elitt, Daniela Schlatzer, H. Elizabeth Shick, Yuka Maeno-Hikichi, Lilianne Barbar, David F. LePage, Weihong Jiang, Hannah E. Olsen, Hien T Zhao, Stevephen Hung, Adam Swayze, Frank Rigo, Paul J. Tesar, Kevin C. Allan, Zachary S. Nevin, Baraa S. Nawash, Masahiro Hitomi, Artur S. Gevorgyan, Mayur Madhavan
Publikováno v:
Nature
Mutations in PLP1, the gene that encodes proteolipid protein (PLP), result in failure of myelination and neurological dysfunction in the X-chromosome-linked leukodystrophy Pelizaeus–Merzbacher disease (PMD)1,2. Most PLP1 mutations, including point
Autor:
Benjamin L.L. Clayton, James D. Kristell, Kevin C. Allan, Molly Karl, Eric Garrison, Yuka Maeno-Hikichi, Annalise M. Sturno, H. Elizabeth Shick, Robert H. Miller, Paul J. Tesar
Disease, injury, and aging induce reactive astrocyte states with pathological functions1-4. In neurodegenerative diseases, inflammatory reactive astrocytes are abundant and contribute to progressive cell loss. Modulating the state or function of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97744fa0614581a8d33f39edd03eb9a9
https://doi.org/10.1101/2021.11.03.467083
https://doi.org/10.1101/2021.11.03.467083
Autor:
Yan Li, Matthew S. Elitt, Zachary S. Nevin, Paul J. Tesar, Angela M. Lager, H. Elizabeth Shick, Chen Weng, Drew J. Adams, Mayur Madhavan, Tyler E. Miller, Kevin C. Allan, Lilianne Barbar, Fulai Jin, Daniel C. Factor, Baraa S. Nawash, Benjamin L.L. Clayton
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 711-726 (2018)
Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancem
Autor:
William K. Wilson, Matthew S. Elitt, Dharmaraja Allimuthu, Paul J. Tesar, Ilya Bederman, Mayur Madhavan, Franz Bracher, H. Elizabeth Shick, Martin Giera, Joel L. Sax, Jing Jin, Yuriy Fedorov, Eric Garrison, Zita Hubler, Drew J. Adams, Kevin C. Allan, Robert H. Miller, Daniel C. Factor, Matthew A. Thompson, Molly Karl, Zachary S. Nevin
Publikováno v:
Nature, 560(7718), 372
Nature
Nature
Regeneration of myelin is mediated by oligodendrocyte progenitor cells (OPCs), an abundant stem cell population in the CNS and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the central nervous
Autor:
Lilianne Barbar, Robert H. Miller, Benjamin L.L. Clayton, Valentina Fossati, Mayur Madhavan, Kevin C. Allan, H. Elizabeth Shick, Eric Garrison, Paul J. Tesar, Zachary S. Nevin, Tanya Jain, Cheryl Clarkson-Paredes, Panagiotis Douvaras, Daniel C. Factor, Molly Karl
Publikováno v:
Nature methods
Organoid technologies provide an accessible system to examine cellular composition, interactions, and organization in the developing human brain, but previously have lacked oligodendrocytes, the myelinating glia of the central nervous system. Here we
Autor:
Masahiro Hitomi, Ronald A. Conlon, Berit Powers, Matthew S. Elitt, Baraa S. Nawash, Zachary S. Nevin, Frank Rigo, David F. LePage, H. Elizabeth Shick, Weihong Jiang, Mayur Madhavan, Paul J. Tesar, Hannah E. Olsen, Kevin C. Allan, Lilianne Barbar, Yuka Maeno-Hikichi
Mutations in proteolipid protein 1 (PLP1) result in failure of myelination and severe neurological dysfunction in the X-linked pediatric leukodystrophy Pelizaeus-Merzbacher disease (PMD). The majority of PLP1 variants, including supernumerary copies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb9aef0fb00a04d13ee97f5b90e39d5
Autor:
Jared M. Cregg, Benjamin L.L. Clayton, Olivia Corradin, Angela M. Lager, Mayur Madhavan, H. Elizabeth Shick, Kevin C. Allan, Paul J. Tesar, Hannah E. Olsen, Matthew S. Elitt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Oligodendrocyte dysfunction underlies many neurological disorders, but rapid assessment of mutation-specific effects in these cells has been impractical. To enable functional genetics in oligodendrocytes, here we report a highly efficient method for