Zobrazeno 1 - 10
of 19
pro vyhledávání: '"H. Edward Wong"'
Autor:
H. Edward Wong, Inchan Kwon
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 9, Pp 22735-22753 (2015)
Techniques to incorporate non-natural amino acids (NNAAs) have enabled biosynthesis of proteins containing new building blocks with unique structures, chemistry, and reactivity that are not found in natural amino acids. It is crucial to understand ho
Externí odkaz:
https://doaj.org/article/d0fcbfe4770e4245883f655fbb95b8a7
Autor:
Diandra Martinez-Cano, Rashmi Ravichandran, Huong Le, H. Edward Wong, Bharat Jagannathan, Erik J. Liu, William Bailey, Jane Yang, Kelli Matthies, Hedieh Barkhordarian, Bhavana Shah, Nithya Srinivasan, Jun Zhang, Angel Hsu, Jette Wypych, Jennitte Stevens, Deirdre Murphy Piedmonte, Les P. Miranda, Lauren Carter, Michael Murphy, Neil P. King, Neil Soice
Publikováno v:
Process Biochemistry. 129:241-256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cdb05762cb3b98d4e5226e4599710f5
https://doi.org/10.1016/j.procbio.2023.03.014
https://doi.org/10.1016/j.procbio.2023.03.014
Autor:
Scott T. Kuhns, David J. Semin, Neil P. Soice, Andy Kappes, H. Edward Wong, Tsang‐Lin Hwang, Robert J. Soto, Andrew T. Csordas, Alexander Wu, Diandra Martinez‐Cano, Melin Babayan, Yesenia Pelayo, Matthew R. Hammond, Yasser Nashed‐Samuel, Chetan T. Goudar
Publikováno v:
Biotechnology progressREFERENCES.
For mammalian cell-derived recombinant biotherapeutics, controlling host cell DNA levels below a threshold is a regulatory requirement to ensure patient safety. DNA removal during drug substance manufacture is accomplished by a series of chromatograp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fbc44d22852dc84c6b4fb57618bb52
https://pubmed.ncbi.nlm.nih.gov/36282232
https://pubmed.ncbi.nlm.nih.gov/36282232
Autor:
null Scott Kuhns, null David J. Semin, null Neil P. Soice, null Andy Kappes, null H. Edward Wong, null Tsang‐Lin Hwang, null Robert J. Soto, null Andrew T. Csordas, null Alexander Wu, null Diandra Martinez‐Cano, null Melin Babayan, null Yesenia Pelayo, null Matthew R. Hammond, null Yasser Nashed‐Samuel, null Chetan T. Goudar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ea85929b2b9cd6d84e907cff4787db4
https://doi.org/10.1002/btpr.3307/v2/response1
https://doi.org/10.1002/btpr.3307/v2/response1
Publikováno v:
Current Opinion in Chemical Engineering. 22:191-198
Manufacturing process of biopharmaceuticals usually starts from culturing recombinant protein producing cells, predominately Chinese Hamster Ovary (CHO) cells, in bioreactors. Currently, fed-batch cell culture process is the most common upstream proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f1ad50cdac0734e8957b21afab71b26
https://doi.org/10.1016/j.coche.2018.10.006
https://doi.org/10.1016/j.coche.2018.10.006
Publikováno v:
Biotechnology Advances. 36:168-181
Proteins provide the molecular basis for cellular structure, catalytic activity, signal transduction, and molecular transport in biological systems. Recombinant protein expression is widely used to prepare and manufacture novel proteins that serve as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09c73c61ee34eaa8ccad3d713632546
https://doi.org/10.1016/j.biotechadv.2017.10.006
https://doi.org/10.1016/j.biotechadv.2017.10.006
Autor:
H Edward Wong, Inchan Kwon
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25752 (2011)
Alzheimer's disease (AD) is the most common form of dementia. AD is a degenerative brain disorder that causes problems with memory, thinking and behavior. It has been suggested that aggregation of amyloid-beta peptide (Aβ) is closely linked to the d
Externí odkaz:
https://doaj.org/article/a3bcc4b6b5d742169011e5adfa45ea35
Publikováno v:
Biochemical Engineering Journal. 109:1-8
The ability to incorporate non-natural amino acids during protein biosynthesis has greatly broadened the amino acid sequence space available for protein engineering. The increasing number of non-natural amino acids provides novel sidechain chemistrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4d302eb98b0209b6c0cd30034a3fc63
https://doi.org/10.1016/j.bej.2015.12.014
https://doi.org/10.1016/j.bej.2015.12.014
Publikováno v:
Biochemistry. 57(49)
Elevated amino acid misincorporation levels during protein translation can cause disease and adversely impact biopharmaceutical product quality. Our previous work, along with that of others, identified numerous low-level unintended sequence variants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c4d3e42e60e93308a7d53f092f91ae
https://pubmed.ncbi.nlm.nih.gov/30418762
https://pubmed.ncbi.nlm.nih.gov/30418762
Publikováno v:
Analytical Biochemistry. 470:61-70
Numerous aromatic small molecule modulators of amyloid-beta peptide (Aβ) monomer aggregation and neurotoxicity have been identified with the ultimate goal of Alzheimer’s disease (AD) treatment. Determining binding sites of these modulators on Aβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cae00ecd3141749c2f02468f28725f9
https://doi.org/10.1016/j.ab.2014.10.016
https://doi.org/10.1016/j.ab.2014.10.016