Zobrazeno 1 - 10
of 70
pro vyhledávání: '"H. Dorota Halicka"'
Publikováno v:
Cytometry Part A. 95:683-690
Described is the new cytometric approach do detect either stimulation or a collapse of lysosomal proton pump (lysosomes rupture) combined with activation of transglutaminase 2 (TG2) during induction of apoptosis. Apoptosis of human lymphoblastoid TK6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0b825d73ceeca0d1d7972901869e28
https://doi.org/10.1002/cyto.a.23652
https://doi.org/10.1002/cyto.a.23652
Publikováno v:
Current Protocols in Cytometry. 89
This unit describes immunocytochemical detection of histone H2AX phosphorylated on Ser-139 (γH2AX) to reveal DNA damage, particularly when the damage involves the presence of DNA double-strand breaks (DSBs). These breaks often result from DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bfc208687ed6a157658630c58e76e3
https://doi.org/10.1002/cpcy.55
https://doi.org/10.1002/cpcy.55
Publikováno v:
Apoptosis. 22:229-238
Utilizing a variety of flow cytometric methods evidence was obtained indicating that a combination of the glucose analog 2-deoxy-D-glucose (2-dG) and the plant alkaloid berberine (BRB) produces synergistic effect in the induction of apoptosis in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca07e7ed53599e39294585404ea88a6
https://doi.org/10.1007/s10495-016-1315-5
https://doi.org/10.1007/s10495-016-1315-5
Autor:
H Dorota, Halicka
Publikováno v:
Cytometry. Part A : the journal of the International Society for Analytical Cytology. 93(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d1ccdfa49a2de4de8ea8aed29b9c3d1
https://pubmed.ncbi.nlm.nih.gov/30176186
https://pubmed.ncbi.nlm.nih.gov/30176186
Publikováno v:
International Journal of Oncology
Programmed cell death ligand 1 (PD‑L1) expressed in cancer cells interacting with its receptor programmed cell death 1 (PD‑1) expressed in immune cells represents a regulatory axis linked to the suppression and evasion of host immune functions. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71070cafc849dcf41cdb41edb3131b06
https://doi.org/10.3892/ijo.2018.4512
https://doi.org/10.3892/ijo.2018.4512
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1644
Activation of caspases is a characteristic event of apoptosis. Various cytometric methods distinguishing this event have been developed to serve as specific apoptotic markers for the assessment of apoptotic frequency within different cell populations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79af4b3b8819f1c9233af1078e8375a5
https://pubmed.ncbi.nlm.nih.gov/28710753
https://pubmed.ncbi.nlm.nih.gov/28710753
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1599
Activation of Ataxia Telangiectasia Mediated protein kinase (ATM) by its phosphorylation on serine 1981 and phosphorylation of histone H2AX on serine 139 (γH2AX) are the key events reporting DNA damage, primarily formation of DNA double strand break
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc7e7b1c8ad618e9d534ba13964a652a
https://pubmed.ncbi.nlm.nih.gov/28477120
https://pubmed.ncbi.nlm.nih.gov/28477120
Publikováno v:
Fast Detection of DNA Damage ISBN: 9781493971855
Activation of caspases is a hallmark of apoptosis. Several methods, therefore, were developed to identify and count the frequency of apoptotic cells based on the detection of caspases activation. The method described in this chapter is based on the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7e288aaa56affb9286635f24aa6220f
https://doi.org/10.1007/978-1-4939-7187-9_5
https://doi.org/10.1007/978-1-4939-7187-9_5
Publikováno v:
Methods in Molecular Biology ISBN: 9781493969531
Activation of Ataxia Telangiectasia Mediated protein kinase (ATM) by its phosphorylation on serine 1981 and phosphorylation of histone H2AX on serine 139 (γH2AX) are the key events reporting DNA damage, primarily formation of DNA double strand break
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccbb117db838d899350ec732b6d83de5
https://doi.org/10.1007/978-1-4939-6955-5_14
https://doi.org/10.1007/978-1-4939-6955-5_14
Autor:
H. Dorota Halicka, Hong Zhao, Tze-chen Hsieh, Jiangwei Li, Yong-Syu Lee, Joseph M. Wu, Zbigniew Darzynkiewicz
Publikováno v:
Cytometry Part A. 85:386-399
This review presents the evidence in support of the IGF-1/mTOR/S6K1 signaling as the primary factor contributing to aging and cellular senescence. Reviewed are also specific interactions between mTOR/S6K1 and ROS-DNA damage signaling pathways. Outlin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9008d8b35d000cc341266e91edbed08
https://doi.org/10.1002/cyto.a.22452
https://doi.org/10.1002/cyto.a.22452