Zobrazeno 1 - 10
of 165
pro vyhledávání: '"H. David Humes"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cell directed therapy is an evolving therapeutic approach to treat organ dysfunction arising from hyperinflammation and cytokine storm by processing immune cells in an extracorporeal circuit. To investigate the mechanism of action of the Sel
Externí odkaz:
https://doaj.org/article/b825e7be3a414f3ca6f310f035866aa2
Autor:
Sai Prasad N. Iyer, PhD, Christopher J. Pino, PhD, Lenar T. Yessayan, MD, Stuart L. Goldstein, MD, Matthew R. Weir, MD, Angela J. Westover, BS, David A. Catanzaro, PharmD, Kevin K. Chung, MD, H. David Humes, MD
Publikováno v:
Transplantation Direct, Vol 10, Iss 6, p e1627 (2024)
A stable, minimum physiological health status is required for patients to qualify for transplant or artificial organ support eligibility to ensure the recipient has enough reserve to survive the perioperative transplant period. Herein, we present a n
Externí odkaz:
https://doaj.org/article/26274fe23cf24edd81834180c8fbe26f
Autor:
Eun Jung Kim, Caressa Chen, Rebecca Gologorsky, Ana Santandreu, Alonso Torres, Nathan Wright, Mark S. Goodin, Jarrett Moyer, Benjamin W. Chui, Charles Blaha, Paul Brakeman, Shant Vartanian, Qizhi Tang, H. David Humes, William H. Fissell, Shuvo Roy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The definitive treatment for end-stage renal disease is kidney transplantation, which remains limited by organ availability and post-transplant complications. Alternatively, an implantable bioartificial kidney could address both problems whi
Externí odkaz:
https://doaj.org/article/0d211e11b47246acb10abcd7f2c4c868
Autor:
H. David Humes, MD, Stuart L. Goldstein, MD, Lenar T. Yessayan, MD, David A. Catanzaro, PharmD, Emily C. Scribe, PharmD, Sai Prasad N. Iyer, PhD, Kevin K. Chung, MD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 10, p e0995 (2023)
OBJECTIVES:. Acute kidney injury (AKI) requiring continuous kidney replacement therapy is a significant complication in ICU patients with mortality rates exceeding 50%. A dysregulated immune response can lead to systemic inflammation caused by hypera
Externí odkaz:
https://doaj.org/article/ae437b8cebe34d67a9023f8e7b1ab77e
Autor:
H. David Humes, Keith D. Aaronson, Deborah A. Buffington, Hani N. Sabbah, Angela J. Westover, Lenar T. Yessayan, Balazs Szamosfalvi, Francis D. Pagani
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
Background Inflammation has been associated with progression and complications of chronic heart failure (HF) but no effective therapy has yet been identified to treat this dysregulated immunologic state. The selective cytopheretic device (SCD) provid
Externí odkaz:
https://doaj.org/article/418062d0858c4f7889c21318c860ad0a
Autor:
Lenar T. Yessayan, MD, MS, Javier A. Neyra, MD, MS, Angela J. Westover, BS, Balazs Szamosfalvi, MD, H. David Humes, MD
Publikováno v:
Critical Care Explorations, Vol 4, Iss 5, p e0694 (2022)
OBJECTIVES:. To evaluate safety and clinical outcomes of extracorporeal immunomodulation treatment with a selective cytopheretic device (SCD) in COVID-19 ICU patients with multiple organ failure. DESIGN:. Two-center, prospective, single-arm treatment
Externí odkaz:
https://doaj.org/article/bee3ca73fad841e98e6f7d1d9dc4db61
Autor:
H. David Humes, Angela J. Westover
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
Externí odkaz:
https://doaj.org/article/6105c3b6c54847369aaa9b95ec3a1a77
Regenerative Medicine and Immunomodulatory Therapy: Insights From the Kidney, Heart, Brain, and Lung
Autor:
Christopher J. Pino, Angela J. Westover, Kimberly A. Johnston, Deborah A. Buffington, H. David Humes
Publikováno v:
Kidney International Reports, Vol 3, Iss 4, Pp 771-783 (2018)
Regenerative medicine was initially focused on tissue engineering to replace damaged tissues and organs with constructs derived from cells and biomaterials. More recently, this field of inquiry has expanded into exciting areas of translational medici
Externí odkaz:
https://doaj.org/article/4241a613bafd40c992e566b788a5b3ad
Autor:
David T. Selewski, Stuart L. Goldstein, Erin Fraser, Katie Plomaritas, Theresa Mottes, Tara Terrell, H. David Humes
Publikováno v:
Kidney International Reports, Vol 2, Iss 6, Pp 1259-1264 (2017)
Externí odkaz:
https://doaj.org/article/fc988c906970493a8462c34ae8da8caf
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Obesity is associated with tissue inflammation which is a crucial etiology of insulin resistance. This inflammation centers around circulating monocytes which form proinflammatory adipose tissue macrophages (ATM). Specific approaches targeting monocy
Externí odkaz:
https://doaj.org/article/734ef56d5ae24833b04f31f1a22ef862