Zobrazeno 1 - 10
of 59
pro vyhledávání: '"H. Darras"'
Autor:
Nafisah M. Al-Rifai, Nemeh M. Al-Khalileh, Jalal A. Zahra, Musa I. El-Barghouthi, Fouad H. Darras
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A library of N-benzylpyridinium-based compounds, 7a-j and 8a-j, was designed and synthesised as potential acetylcholinesterase) AChE (inhibitors. An in vitro assay for the synthesised compounds showed that most compounds had significant AChE inhibito
Externí odkaz:
https://doaj.org/article/6dc8d82ad22847ecaf9e068e09a1bc69
Publikováno v:
Science. 380:55-58
Multicellular organisms typically develop from a single fertilized egg and therefore consist of clonal cells. We report an extraordinary reproductive system in the yellow crazy ant. Males are chimeras of haploid cells from two divergent lineages: R a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df48b4fff70d0df16c52d2122bb941c
https://doi.org/10.1126/science.adf0419
https://doi.org/10.1126/science.adf0419
Publikováno v:
Marine Drugs, Vol 13, Iss 3, Pp 1519-1547 (2015)
Despite the numerous uses of chitin and chitosan as new functional materials of high potential in various fields, they are still behind several directly compressible excipients already dominating pharmaceutical applications. There are, however, new a
Externí odkaz:
https://doaj.org/article/01adc253b51442359984d977e3e6b75e
Akademický článek
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Autor:
Khalid A. Ibrahim, Bassam I. El-Eswed, Khaleel A. Abu-Sbeih, Tawfeeq A. Arafat, Mahmoud M. H. Al Omari, Fouad H. Darras, Adnan A. Badwan
Publikováno v:
Marine Drugs, Vol 14, Iss 8, p 43 (2016)
An increasing interest has recently been shown to use chitin/chitosan oligomers (chito-oligomers) in medicine and food fields because they are not only water-soluble, nontoxic, and biocompatible materials, but they also exhibit numerous biological pr
Externí odkaz:
https://doaj.org/article/110934e71d8c489596a119a44d3b992a
Autor:
Fouad H. Darras, Yuan Ping Pang
Defined as a state function representing an inhibitor’s absolute affinity for its target enzyme, the experimentally determined enzyme inhibition constant (Ki) is widely used to rank order binding affinities of different inhibitors for a common enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7db5e4fa838c6ce0d00d71624ff529c
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:5020-5034
A series of cyclic acyl guanidine with carbamate moieties have been synthesized and evaluated in vitro for their AChE and BChE inhibitory activities. Structure−activity relationships identified compound 23 as a nanomolar and selective BChE inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096a8585009d0be62d57d50fe908b597
https://doi.org/10.1016/j.bmc.2014.06.010
https://doi.org/10.1016/j.bmc.2014.06.010
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3938-3946
The design of bivalent ligands targeting G protein-coupled receptors (GPCRs) often leads to the development of new, highly selective and potent compounds. To date, no bivalent ligands for the human cannabinoid receptor type 2 (hCB2R) of the endocanna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f9f9ab15465b97ebc3f153673a2d72
https://doi.org/10.1016/j.bmc.2014.06.008
https://doi.org/10.1016/j.bmc.2014.06.008
Autor:
Sarah Wehle, Steffen Pockes, Martin Nimczick, Christoph A. Sotriffer, Andrea Strasser, Hans-Joachim Wittmann, Guozheng Huang, Michael Decker, Fouad H. Darras
Publikováno v:
ACS Chemical Neuroscience. 5:225-242
Combination of AChE inhibiting and histamine H3 receptor antagonizing properties in a single molecule might show synergistic effects to improve cognitive deficits in Alzheimer's disease, since both pharmacological actions are able to enhance choliner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990d4709b73fec1f99cd519ae5dd61e8
https://doi.org/10.1021/cn4002126
https://doi.org/10.1021/cn4002126
Akademický článek
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