Zobrazeno 1 - 10
of 13
pro vyhledávání: '"H. D. H. Showalter"'
Publikováno v:
Diabetes, Obesity and Metabolism. 13:434-438
Aim: To assess the safety, tolerability, pharmacokinetics, pharmacodynamics and potential immunogenicity of single, escalating subcutaneous injections of a once-weekly glucagon-like peptide-1 analogue in healthy subjects. Methods: This phase 1, three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a8f9b07a98e07cadeb822d8e3a4cd4
https://doi.org/10.1111/j.1463-1326.2011.01365.x
https://doi.org/10.1111/j.1463-1326.2011.01365.x
Autor:
Thomas Hardy, S. Cui, F. Tibaldi, B. Ellis, H. D. H. Showalter, P. Barrington, K. Schneck, Jenny Y. Chien
Publikováno v:
Diabetes, Obesity and Metabolism. 13:426-433
Aim: To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of LY2189265 (LY), a novel, long-acting glucagen-like peptide-1 analogue, administered once weekly to subjects with type 2 diabetes. Methods: This was a placebo-contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736c7c0c9e6cba6e29026671f9427165
https://doi.org/10.1111/j.1463-1326.2011.01364.x
https://doi.org/10.1111/j.1463-1326.2011.01364.x
Autor:
Jeffrey Bruce Smaill, Brian D. Palmer, Alexander James Bridges, Bill J. Roberts, James M. Nelson, David W. Fry, Ellen M. Dobrusin, Gordon W. Rewcastle, R. T. Winters, W. L. Elliot, H. D. H. Showalter, S. J. Patmore, Patrick W. Vincent, William A. Denny, Zhou Hairong, W. R. Leopold, Dennis J. McNamara, V. Slintak
Publikováno v:
Journal of medicinal chemistry. 42(10)
A series of 6- and 7-acrylamide derivatives of the 4-(phenylamino)quinazoline and -pyridopyrimidine classes of epidermal growth factor receptor (EGFR) inhibitors were prepared from the corresponding amino compounds by reaction with either acryloyl ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97436fcf0b3737c2c47c6ea5c3bc1d50
https://pubmed.ncbi.nlm.nih.gov/10346932
https://pubmed.ncbi.nlm.nih.gov/10346932
Autor:
William A. Denny, Jeffrey Bruce Smaill, AM Doherty, James M. Hamby, Alan J. Kraker, Brian D. Palmer, TK Dahring, JB Kramer, DH Boschelli, Khatana Ss, Maruta Boyd, Robert L. Panek, R. T. Winters, Gina H. Lu, H. D. H. Showalter
Publikováno v:
Journal of medicinal chemistry. 41(27)
1-Phenylbenzimidazoles are shown to be a new class of ATP-site inhibitors of the platelet-derived growth factor receptor (PDGFR). Structure-activity relationships (SARs) are narrow, with closely related heterocycles being inactive. A systematic study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b1b5f2bcf503f1d520e1f7178e91ca
https://pubmed.ncbi.nlm.nih.gov/9876115
https://pubmed.ncbi.nlm.nih.gov/9876115
Autor:
James M. Nelson, Gordon W. Rewcastle, D. K. Murray, Patrick W. Vincent, Curtis T. Howard, H. D. H. Showalter, William A. Denny, Bill J. Roberts, William L. Elliott, R. T. Winters, David W. Fry
Publikováno v:
Journal of medicinal chemistry. 41(5)
The 4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidine PD 158780 is a very potent in vitro inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC50 0.08 nM), and other members of the erbB family, by competitive bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b32f47d98b700584ad8a6f6e0f0890
https://pubmed.ncbi.nlm.nih.gov/9513602
https://pubmed.ncbi.nlm.nih.gov/9513602
Publikováno v:
Chemischer Informationsdienst. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c05e068b8f78a7913ea5d34862136fc2
https://doi.org/10.1002/chin.198402176
https://doi.org/10.1002/chin.198402176
Publikováno v:
Chemischer Informationsdienst. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c35ac898d636df4352c2b050889bb8ee
https://doi.org/10.1002/chin.198232209
https://doi.org/10.1002/chin.198232209
Publikováno v:
Chemischer Informationsdienst. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::659889fd74be22eabbdcc56f181cb751
https://doi.org/10.1002/chin.198307307
https://doi.org/10.1002/chin.198307307
Publikováno v:
Chemischer Informationsdienst. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bdbc0ac3ba7dd04e9136947551241d3
https://doi.org/10.1002/chin.197845335
https://doi.org/10.1002/chin.197845335
Autor:
H. D. H. SHOWALTER, T. H. HASKELL
Publikováno v:
Chemischer Informationsdienst. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55045fe495602e8506fb1d11ece30137
https://doi.org/10.1002/chin.198148233
https://doi.org/10.1002/chin.198148233