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Autoradiography in brain ofMacaca fascicularis monkeys after injection of acetyl-DL-leucine [2-14C] (Tanganil®)

Autor: C. Germain, P. Benard, T. Bengone, H. Cousse

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 26:71-76

Acetyl-DL-leucine [2-14C]: Tanganil® a antivertigal drug has been injected intravenously in two macaca monkeys which have been sacrificed 2 and 5 minutes later. Radioactivity distribution has been studied by autoradiography in the brain. An importan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08815d075bd95959998d8a6cca7a7b9
https://doi.org/10.1007/bf03190379

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Effect of the lipidosterolic extract of Serenoa repens (Permixon) and its major components on basic fibroblast growth factor-induced proliferation of cultures of human prostate biopsies

Autor: M, Paubert-Braquet, H, Cousse, J P, Raynaud, J M, Mencia-Huerta, P, Braquet

Publikováno v: European urology. 33(3)

To assess the effect of the lipidosterolic extract of Serenoa repens (LSESr) on in vitro cell proliferation in biopsies of human prostateCell proliferation was assessed by incorporation of [3H]thymidine followed by historadiography.Basic fibroblast g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13d12e86287651515a633d3faaf2cf2b
https://pubmed.ncbi.nlm.nih.gov/9555564

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Effect of the lipidic lipidosterolic extract of Serenoa repens (Permixon) on the ionophore A23187-stimulated production of leukotriene B4 (LTB4) from human polymorphonuclear neutrophils

Autor: M. Paubert-Braquet, Pierre Braquet, J.-M. Mencia Huerta, H. Cousse

Publikováno v: Prostaglandins, leukotrienes, and essential fatty acids. 57(3)

Although the lipidic extract of Serenoa repens (LESSr, Permixon, Sereprostat) is widely used in patients suffering from benign prostatic hypertrophy (BPH), its mechanism of action is not fully elucidated. It has been demonstrated that infiltration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc0cfcc5660730df3e91daa34dae2a2
https://pubmed.ncbi.nlm.nih.gov/9384520

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Distribution study of radioactivity in rats after oral administration of the lipido/sterolic extract of Serenoa repens (Permixon) supplemented with [1-14C]-lauric acid, [1-14C]-oleic acid or [4-14C]-beta-sitosterol

Autor: H. Cousse, G. Chevalier, T. Bengone, P. Benard

Publikováno v: European journal of drug metabolism and pharmacokinetics. 22(1)

The study carried out on rats given orally the n-hexane lipido/sterolic extract of Serenoa repens (LSESR), supplemented with [14C]-labelled oleic or lauric acids or beta-sitosterol, demonstrated that radioactivity uptake in prostatic tissues shows th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb9c6879a62928e36f91cd9320488ce
https://pubmed.ncbi.nlm.nih.gov/9179563

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Correlations entre la structure et des paramêtres pharmacocinétiques dans une série d' amides crésotiniques

Autor: J.L. Chanal, R. Marignan, G. Berge, M. Audran, H. Cousse

Publikováno v: International Journal of Pharmaceutics. 20:129-137

Pharmacokinetics of seven cresotinamids was studied in rat: half-life, distribution volume, total clearance were calculated. Correlations between these pharmac akinetic parameters and the characteristic physicochemical parameters (pKa, lipophilia, st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07316cd273c0e668ad14cc13f79e7240
https://doi.org/10.1016/0378-5173(84)90224-2

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Absorption and elimination of (14C) hesperidin methylchalcone in the rat

Autor: M T Sicart, H Cousse, Marignan R, J L Chanal, B Bonnaud

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 6:171-177

Hesperidin methylchalcone resorption and excretion were studied in rats, using 14C-labelling. The level of radioactivity in the blood showed a peak 1-2 hours after oral administration of the labelled compound, at a dose of 10 mg/kg body weight. The b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112056b418bcd02e993f7a1ccdea317d
https://doi.org/10.1007/bf03189486

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