Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging

Autor: Wang Yuan, Yi M. Weaver, Svetlana Earnest, Clinton A. Taylor, Melanie H. Cobb, Benjamin P. Weaver

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract The conserved p38 MAPK family is activated by phosphorylation during stress responses and inactivated by phosphatases. C. elegans PMK-1 p38 MAPK initiates innate immune responses and blocks development when hyperactivated. Here we show that

Externí odkaz: https://doaj.org/article/cb50195b62e840468d6c3a22506f3b03

Navigating the ERK1/2 MAPK Cascade

Autor: Ana Martin-Vega, Melanie H. Cobb

Publikováno v: Biomolecules, Vol 13, Iss 10, p 1555 (2023)

The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all cell types. Notably, ERK1/2 are implicated in specific processes in a co

Externí odkaz: https://doaj.org/article/c0b4012c17374b3199887710ab3986e5

WNK1 in Malignant Behaviors: A Potential Target for Cancer?

Autor: Ji-Ung Jung, Ankita B. Jaykumar, Melanie H. Cobb

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Metastasis is the major cause of mortality in cancer patients. Analyses of mouse models and patient data have implicated the protein kinase WNK1 as one of a handful of genes uniquely linked to a subset of invasive cancers. WNK1 signaling pathways are

Externí odkaz: https://doaj.org/article/1928326a99e84ee383f1ab3bbee86022

First particle-by-particle measurement of emittance in the Muon Ionization Cooling Experiment

Autor: MICE Collaboration, D. Adams, D. Adey, R. Asfandiyarov, G. Barber, A. de Bari, R. Bayes, V. Bayliss, R. Bertoni, V. Blackmore, A. Blondel, J. Boehm, M. Bogomilov, M. Bonesini, C. N. Booth, D. Bowring, S. Boyd, T. W. Bradshaw, A. D. Bross, C. Brown, G. Charnley, G. T. Chatzitheodoridis, F. Chignoli, M. Chung, D. Cline, J. H. Cobb, D. Colling, N. Collomb, P. Cooke, M. Courthold, L. M. Cremaldi, A. DeMello, A. J. Dick, A. Dobbs, P. Dornan, F. Drielsma, K. Dumbell, M. Ellis, F. Filthaut, P. Franchini, B. Freemire, A. Gallagher, R. Gamet, R. B. S. Gardener, S. Gourlay, A. Grant, J. R. Greis, S. Griffiths, P. Hanlet, G. G. Hanson, T. Hartnett, C. Heidt, P. Hodgson, C. Hunt, S. Ishimoto, D. Jokovic, P. B. Jurj, D. M. Kaplan, Y. Karadzhov, A. Klier, Y. Kuno, A. Kurup, P. Kyberd, J-B. Lagrange, J. Langlands, W. Lau, D. Li, Z. Li, A. Liu, K. Long, T. Lord, C. Macwaters, D. Maletic, B. Martlew, J. Martyniak, R. Mazza, S. Middleton, T. A. Mohayai, A. Moss, A. Muir, I. Mullacrane, J. J. Nebrensky, D. Neuffer, A. Nichols, J. C. Nugent, A. Oates, D. Orestano, E. Overton, P. Owens, V. Palladino, M. Palmer, J. Pasternak, V. Pec, C. Pidcott, M. Popovic, R. Preece, S. Prestemon, D. Rajaram, S. Ricciardi, M. Robinson, C. Rogers, K. Ronald, P. Rubinov, H. Sakamoto, D. A. Sanders, A. Sato, M. Savic, P. Snopok, P. J. Smith, F. J. P. Soler, Y. Song, T. Stanley, G. Stokes, V. Suezaki, D. J. Summers, C. K. Sung, J. Tang, J. Tarrant, I. Taylor, L. Tortora, Y. Torun, R. Tsenov, M. Tucker, M. A. Uchida, S. Virostek, G. Vankova-Kirilova, P. Warburton, S. Wilbur, A. Wilson, H. Witte, C. White, C. G. Whyte, X. Yang, A. R. Young, M. Zisman

Publikováno v: European Physical Journal C: Particles and Fields, Vol 79, Iss 3, Pp 1-15 (2019)

Abstract The Muon Ionization Cooling Experiment (MICE) collaboration seeks to demonstrate the feasibility of ionization cooling, the technique by which it is proposed to cool the muon beam at a future neutrino factory or muon collider. The emittance

Externí odkaz: https://doaj.org/article/f79764e4ca3641f4af2a384cea66e769

Control of Podocyte and Glomerular Capillary Wall Structure and Elasticity by WNK1 Kinase

Autor: Zhenan Liu, Joonho Yoon, Chonlarat Wichaidit, Ankita B. Jaykumar, Hashem A. Dbouk, Addie E. Embry, Liping Liu, Joel M. Henderson, Audrey N. Chang, Melanie H. Cobb, Richard Tyler Miller

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2021)

Cytoskeletal structure and its regulation are essential for maintenance of the differentiated state of specific types of cells and their adaptation to physiologic and pathophysiologic conditions. Renal glomerular capillaries, composed of podocytes, e

Externí odkaz: https://doaj.org/article/574eb57a64854f5b92b6fd2734e682dd