Zobrazeno 1 - 10 of 26 pro vyhledávání: '"H. C. Parkington"'
1
The application of human pluripotent stem cells to model the neuronal and glial components of neurodevelopmental disorders
Autor: K M, Lee, Z H, Hawi, H C, Parkington, C L, Parish, P V, Kumar, J M, Polo, M A, Bellgrove, J, Tong
Publikováno v: Molecular psychiatry. 25(2)
Cellular models of neurodevelopmental disorders provide a valuable experimental system to uncover disease mechanisms and novel therapeutic strategies. The ability of induced pluripotent stem cells (iPSCs) to generate diverse brain cell types offers g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53a89af1bfa763adcc1bcb1e8b0280a7
https://pubmed.ncbi.nlm.nih.gov/31455859
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2
Glucocorticoid treatment does not alter early cardiac adaptations to growth restriction in preterm sheep fetuses
Autor: M, Tare, S L, Miller, E M, Wallace, A E, Sutherland, T, Yawno, H A, Coleman, G, Jenkin, H C, Parkington
Publikováno v: BJOG : an international journal of obstetrics and gynaecology. 119(8)
To study the consequences of glucocorticoid treatment in fetal growth restriction (FGR) on cardiac function.Laboratory.Sheep. Growth restriction was induced in sheep fetuses using single umbilical artery ligation (SUAL) on days 105-110 of gestation (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1579efdbd1d216ccd7d731b2f2509b14
https://pubmed.ncbi.nlm.nih.gov/22703419
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3
Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPARγ-dependent and PPARγ-independent mechanisms
Autor: J R, Rao, D J, Keating, C, Chen, H C, Parkington
Publikováno v: Diabetes, obesitymetabolism. 14(11)
Adiponectin is an important adipokine whose levels are decreased in obesity despite increases in adipocyte mass. Studies in animal models implicate adiponectin as an insulin sensitizer in skeletal muscle and liver. Thiazolidinediones (TZDs) are insul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1cf64f95c29fafe6d8e91db6ca26a62c
https://pubmed.ncbi.nlm.nih.gov/22594400
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4
Oxytocin depolarizes mitochondria in isolated myometrial cells
Autor: F S, Gravina, P, Jobling, K P, Kerr, R B, de Oliveira, H C, Parkington, D F, van Helden
Publikováno v: Experimental physiology. 96(9)
Oxytocin is known to play important roles in uterine contractions, mediated at least in part by increasing intracellular Ca(2+) concentration ([Ca(2+)](i)), through enhancing extracellular Ca(2+) entry and Ca(2+) release from the sarcoplasmic reticul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba8489de723497e3d90be369f3265dc7
https://pubmed.ncbi.nlm.nih.gov/21666036
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5
Role of mitochondria in contraction and pacemaking in the mouse uterus
Autor: F S, Gravina, H C, Parkington, K P, Kerr, R B, de Oliveira, P, Jobling, H A, Coleman, S L, Sandow, M M, Davies, M S, Imtiaz, D F, van Helden
Publikováno v: British journal of pharmacology. 161(6)
Uterine spontaneous contraction and pacemaking are poorly understood. This study investigates the role of the mitochondrial Ca(2+) store in uterine activity.We investigated the effects of mitochondrial and sarco-endoplasmic reticulum (SER) inhibitors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8d4f09d95282014df74ca77bc37bc9e
https://pubmed.ncbi.nlm.nih.gov/20942856
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7
Role of Ca2+ entry and Ca2+ stores in atypical smooth muscle cell autorhythmicity in the mouse renal pelvis
Autor: R J, Lang, H, Hashitani, M A, Tonta, H, Suzuki, H C, Parkington
Publikováno v: British journal of pharmacology. 152(8)
Electrically active atypical smooth muscle cells (ASMCs) within the renal pelvis have long been considered to act as pacemaker cells driving pelviureteric peristalsis. We have investigated the role of Ca2+ entry and uptake into and release from inter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a49fcf3b0c9fb7ef579b18eae872f4cf
https://pubmed.ncbi.nlm.nih.gov/17965738
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8
How important is stimulation of alpha-adrenoceptors for melatonin production in rat pineal glands?
Autor: V A, Tobin, I, McCance, H A, Coleman, H C, Parkington
Publikováno v: Journal of pineal research. 32(4)
The objective of this study was to determine the role of alpha-adrenoceptors in melatonin production by rat pineal gland. Pineal glands were isolated from adult male rats and maintained in organ baths. The perfusate was sampled every 5 min, stored, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd4cc0eb9a0961b538a2249cca844083
https://pubmed.ncbi.nlm.nih.gov/11982790
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10
EDHF, NO and a prostanoid: hyperpolarization-dependent and -independent relaxation in guinea-pig arteries
Autor: M, Tare, H C, Parkington, H A, Coleman
Publikováno v: British journal of pharmacology. 130(3)
The contribution of endothelium-derived hyperpolarizing factor (EDHF), nitric oxide (NO) and a prostanoid (PG) to endothelium-dependent hyperpolarization and relaxation were assessed in coronary and mammary arteries of guinea-pigs by integration of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::844733567de3ec294872e71ffe261eaf
https://pubmed.ncbi.nlm.nih.gov/10821789
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