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Cell surface expression of the C3b/C4b receptor (CR1) protects Chinese hamster ovary cells from lysis by human complement

Autor: P J Ford, K S Evans, Savvas C. Makrides, Susanne M. Scesney, G R Carson, H C Marsh

Publikováno v: Journal of Biological Chemistry. 267:24754-24761

The C3b/C4b receptor, also known as complement receptor type 1 (CR1, CD35), is a single chain glycoprotein consisting of 30 repeating homologous protein domains known as short consensus repeats (SCR) followed by transmembrane and cytoplasmic domains.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3a890d604851f381150b24546667472
https://doi.org/10.1016/s0021-9258(18)35828-9

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Reduction of myocardial infarct size with sCR1sLe(x), an alternatively glycosylated form of human soluble complement receptor type 1 (sCR1), possessing sialyl Lewis x

Autor: K, Zacharowski, M, Otto, G, Hafner, H C, Marsh, C, Thiemermann

Publikováno v: British journal of pharmacology. 128(5)

1 This study investigated the effects of soluble complement receptor type 1 (sCR1) or sCR1sLex, agents which function as a complement inhibitor or as a combined complement inhibitor and selectin adhesion molecule antagonist, respectively, on the infa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc6268a920334269f4a7683ff2044b92
https://pubmed.ncbi.nlm.nih.gov/10556930

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IgG and complement-mediated tissue damage in the absence of C2: evidence of a functionally active C2-bypass pathway in a guinea pig model

Autor: E, Wagner, J L, Platt, D N, Howell, H C, Marsh, M M, Frank

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(6)

In vitro complement-mediated lysis of heavily sensitized sheep erythrocytes by C4-deficient (C4D) guinea pig and C2-deficient (C2D) human sera was demonstrated some years ago. It was postulated that these "complement-bypass" pathways resulted from ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37b41d67e4af465259b0a6290ff7527c
https://pubmed.ncbi.nlm.nih.gov/10477630

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Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts

Autor: S K, Pruitt, R R, Bollinger, B H, Collins, H C, Marsh, J L, Levin, A R, Rudolph, W M, Baldwin, F, Sanfilippo

Publikováno v: Transplantation. 63(6)

A single bolus of soluble complement (C) receptor type 1 (sCR1, TP-10) has been shown to delay hyperacute rejection (HAR) of porcine cardiac xenografts (Xgs) by primate recipients. In these recipients, C activity slowly returned and C deposition was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b55af52d5e4e75643ae132d7756077c1
https://pubmed.ncbi.nlm.nih.gov/9089232

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Therapeutic Effect of Soluble Complement Receptor Type 1 in Xenotransplantation

Autor: U. S. Ryan, H. C. Marsh

Publikováno v: Xenotransplantation ISBN: 9783642644603

The immediate and devastating effects of hyperacute rejection in xenotransplantation have tended to focus research and therapeutic strategies on this major hurdle, and there is no question that without such strategies the problems facing xenotranspla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37050fa31670d88f4590a857875fa43d
https://doi.org/10.1007/978-3-642-60572-7_33

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Soluble complement receptor type 1 and cobra venom factor in discordant xenotransplantation

Autor: D, Candinas, B A, Lesnikoski, S C, Robson, S M, Scesney, I, Otsu, T, Myiatake, H C, Marsh, U S, Ryan, W W, Hancock, F H, Bach

Publikováno v: Transplantation proceedings. 28(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0789eed46cae173c8ed38b1439392e74
https://pubmed.ncbi.nlm.nih.gov/8623282

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Continuous complement (C) inhibition using soluble C receptor type 1 (sCR1): effect on hyperacute rejection (HAR) of pig-to-primate cardiac xenografts

Autor: S k, Pruitt, R R, Bollinger, B H, Collins, H C, Marsh, J L, Levin, A R, Rudolph, W M, Baldwin, F, Sanfilippo

Publikováno v: Transplantation proceedings. 28(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::febc614d26c4967a14fd55a85a624526
https://pubmed.ncbi.nlm.nih.gov/8623382

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Quantitative analysis of C4b dimer binding to distinct sites on the C3b/C4b receptor (CR1)

Autor: B D, Reilly, S C, Makrides, P J, Ford, H C, Marsh, C, Mold

Publikováno v: The Journal of biological chemistry. 269(10)

The complement receptor CR1 (CD35) is a transmembrane protein composed in its extracellular portion of short consensus repeats (SCR 1-30) organized into four long homologous repeats (LHR-A, LHR-B, LHR-C, and LHR-D). Each LHR, except LHR-D, contains a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2940892f84f693ab39f6f59267e3f7ae
https://pubmed.ncbi.nlm.nih.gov/8125996

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Cell surface expression of the C3b/C4b receptor (CR1) protects Chinese hamster ovary cells from lysis by human complement

Autor: S C, Makrides, S M, Scesney, P J, Ford, K S, Evans, G R, Carson, H C, Marsh

Publikováno v: The Journal of biological chemistry. 267(34)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7471116b9007c038d41873ab9121a9e
https://pubmed.ncbi.nlm.nih.gov/1447213

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