Zobrazeno 1 - 10
of 245
pro vyhledávání: '"H. Bryan Brewer"'
Autor:
Frank M. Sacks, Lawrence L. Rudel, Adam Conner, Hassibullah Akeefe, Gerhard Kostner, Talal Baki, George Rothblat, Margarita de la Llera-Moya, Bela Asztalos, Timothy Perlman, Chunyu Zheng, Petar Alaupovic, Jo-Ann B. Maltais, H. Bryan Brewer
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 5, Pp 894-907 (2009)
Uptake of cholesterol from peripheral cells by nascent small HDL circulating in plasma is necessary to prevent atherosclerosis. This process, termed reverse cholesterol transport, produces larger cholesterol-rich HDL that transfers its cholesterol to
Externí odkaz:
https://doaj.org/article/d513fad01fe641f1b35de3dde5c04ef5
Autor:
Lita Freeman, Marcelo J.A. Amar, Robert Shamburek, Beverly Paigen, H. Bryan Brewer, Jr., Silvia Santamarina-Fojo, Herminia González-Navarro
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 1, Pp 104-113 (2007)
To elucidate the separate contributions of the lipolytic versus ligand-binding functions of hepatic lipase (HL) to lipoprotein metabolism and atherosclerosis, and to investigate the role of the low density lipoprotein receptor (LDLr) in these process
Externí odkaz:
https://doaj.org/article/30b42f6bb4c049c084f4aeede4f15d45
Autor:
Federica Basso, Lita A. Freeman, Carol Ko, Charles Joyce, Marcelo J. Amar, Robert D. Shamburek, Terese Tansey, Fairwell Thomas, Justina Wu, Beverly Paigen, Alan T. Remaley, Silvia Santamarina-Fojo, H. Bryan Brewer, Jr.
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 1, Pp 114-126 (2007)
We previously reported that liver-specific overexpression of ABCG5/G8 in mice is not atheroprotective, suggesting that increased biliary cholesterol secretion must be coupled with decreased intestinal cholesterol absorption to increase net sterol los
Externí odkaz:
https://doaj.org/article/6b6bbb105a6d4b7691fc3ab212ba8c95
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2151-2167 (2005)
The ABC transporter ABCG1 (ATP binding cassette transporter G1), expressed in macrophages, liver, and other tissues, has been implicated in the efflux of cholesterol to high density lipoprotein. The ABCG1 gene is transcriptionally activated by choles
Externí odkaz:
https://doaj.org/article/0daf62c596894e06ae1b59125ac2afb3
Autor:
Florent Lalanne, Gilles Lambert, Marcelo J.A. Amar, Maud Chétiveaux, Yassine Zaïr, Anne-Laure Jarnoux, Khadija Ouguerram, José Friburg, Nabil G. Seidah, H. Bryan Brewer, Jr., Michel Krempf, Philippe Costet
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 6, Pp 1312-1319 (2005)
Mutations in Proprotein Convertase Subtilisin Kexin 9 (PCSK9) have been associated with autosomal dominant hypercholesterolemia. In vivo kinetic studies indicate that LDL catabolism was impaired and apolipoprotein B (apoB)-containing lipoprotein synt
Externí odkaz:
https://doaj.org/article/041a7dbf2f404624bc3b0e8212a56abd
Autor:
Katsunori Ikewaki, William Cain, Fairwell Thomas, Robert Shamburek, Loren A. Zech, David Usher, H. Bryan Brewer, Jr., Daniel J. Rader
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1302-1311 (2004)
The present study was undertaken to elucidate the metabolic basis for the increased remnants and lipoprotein(a) [Lp(a)] and decreased LDL apolipoprotein B (apoB) levels in human apoE deficiency. A primed constant infusion of 13C6-phenylalanine was ad
Externí odkaz:
https://doaj.org/article/dc4a626e0d2344db8fe76dc867c0e9c0
Autor:
Lita A. Freeman, Arion Kennedy, Justina Wu, Samantha Bark, Alan T. Remaley, Silvia Santamarina-Fojo, H. Bryan Brewer, Jr.
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1197-1206 (2004)
The ATP binding cassette (ABC) half-transporters ABCG5 and ABCG8 facilitate biliary and intestinal removal of neutral sterols. Here, we identify a binding site for the orphan nuclear receptor liver receptor homolog-1 (LRH-1) at nt 134–142 of the AB
Externí odkaz:
https://doaj.org/article/f240ee8826674eafaaa342beb01bb3c0
The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene
Autor:
Xiao-Ping Yang, Lita A. Freeman, Catherine L. Knapper, Marcelo J.A. Amar, Alan Remaley, H. Bryan Brewer, Jr., Silvia Santamarina-Fojo
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 2, Pp 297-306 (2002)
To identify regulatory elements in the proximal human ATP-binding cassette transporter A1 (hABCA1) gene promoter we transfected RAW cells with plasmids containing mutations in the E-box, AP1, and liver X receptor (LXR) elements as well as the two Sp1
Externí odkaz:
https://doaj.org/article/0a5a7f5833844f6cab090a3b646b1d62
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 9, Pp 1339-1345 (2001)
The discovery of the role of the ATP-binding cassette transporter A1 (ABCA1) in mediating apolipoprotein A-I-mediated efflux has led to a dramatic increase in our knowledge of the molecular mechanisms involved in cholesterol efflux and cellular metab
Externí odkaz:
https://doaj.org/article/b8983e5144f14476ace7949d95d33553
Autor:
Gilles Lambert, Marcelo J.A. Amar, Pascal Martin, Jamila Fruchart-Najib, Bernhard Föger, Robert D. Shamburek, H. Bryan Brewer, Jr., Silvia Santamarina-Fojo
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 5, Pp 667-672 (2000)
Recent in vitro studies have provided evidence that hepatic lipase (HL) facilitates the selective uptake of HDL cholesteryl esters (CE), but the in vivo physiological relevance of this process has not been demonstrated. To evaluate the role that HL p
Externí odkaz:
https://doaj.org/article/8773865be0d24181b419899c58ec3f0d