Výsledky vyhledávání - "H. B. Salvesen"

Molecular differences between RER+ and RER– sporadic endometrial carcinomas in a large population-based series

Autor: N. D. Macdonald, H. B. Salvesen, A. Ryan, S. Malatos, I. Stefansson, O. E. Iversen, L. A. Akslen, S. Das, I. J. Jacobs

Publikováno v: International Journal of Gynecologic Cancer. 14:957-965

Studies, to date, have suggested that there are distinct molecular differences between microsatellite stable (RER–) and unstable (RER+) solid tumors, such as colorectal carcinoma. We investigated a range of molecular events including mutation frequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dca956a79e0860caac4bd2193115189b
https://doi.org/10.1136/ijgc-00009577-200409000-00032

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[Role of lymphadenectomy in the surgery of gynecologic cancer]

Autor: H B, Salvesen

Publikováno v: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. 121(10)

Complete surgical removal of cancer tissue is a goal in modern cancer treatment, and this is one of the arguments for total lymphadenectomy in gynaecologic cancer surgery.Review of the literature identified through limited searches on Medline, Cochra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83ef9998a51e585858250ee5b1829c6d
https://pubmed.ncbi.nlm.nih.gov/11402752

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[Routine follow up after treatment for gynecological cancer]

Autor: H B, Salvesen

Publikováno v: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. 121(10)

Cancer patients are traditionally given follow-up. An earlier diagnosis of recurrent disease is thought to improve chances for curative treatment. The aim of this study was to investigate the approach to routine follow-up after treatment for gynecolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ded45452bc9a7cfa059049b66f6ff0dc
https://pubmed.ncbi.nlm.nih.gov/11402754

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PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma

Autor: H B, Salvesen, N, MacDonald, A, Ryan, I J, Jacobs, E D, Lynch, L A, Akslen, S, Das

Publikováno v: International journal of cancer. 91(1)

Loss of heterozygosity and mutations in the PTEN (MMAC1) tumor suppressor gene are frequent in endometrial carcinoma. Promoter hypermethylation has recently been identified as an alternative mechanism of tumor suppressor gene inactivation in cancer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4856c55a216c370508b3b5755553d604
https://pubmed.ncbi.nlm.nih.gov/11149415

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Loss of estrogen receptor (ER) expression in endometrial tumors is not associated with de novo methylation of the 5' end of the ER gene

Autor: J R, Navari, P Y, Roland, P, Keh, H B, Salvesen, L A, Akslen, O E, Iversen, S, Das, R, Kothari, S, Howey, B, Phillips

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(10)

Normal endometrium, an estrogen-responsive tissue, expresses the estrogen receptor (ER) alpha gene. Loss of ER expression, the basis for which is currently unknown, is often seen in advanced stage, poor prognosis endometrial tumors. The ER gene under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4109bc886d8a5623bb49f261eb2f83e6
https://pubmed.ncbi.nlm.nih.gov/11051252

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Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis

Autor: H B, Salvesen, S, Das, L A, Akslen

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(1)

The p16INK4aa (CDKN2) tumor suppressor gene is altered in several tumor types, but the frequency and mechanism of inactivation are largely unknown for endometrial carcinomas. We therefore wanted to assess the pattern and prognostic impact of p16 prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03475aa4009ee7438161ce3543918d9c
https://pubmed.ncbi.nlm.nih.gov/10656444

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Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas

Autor: H B, Salvesen, L A, Akslen

Publikováno v: International journal of cancer. 84(5)

Angiogenesis is a key process in tumour growth and metastasis, and microvessel density has been found to influence the prognosis of endometrial carcinoma patients. Less is known about regulators of angiogenesis. Studies of other tumour types have ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef21652bc4ea750556fa01213b6bfe1c
https://pubmed.ncbi.nlm.nih.gov/10502735

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Identification of high-risk patients by assessment of nuclear Ki-67 expression in a prospective study of endometrial carcinomas

Autor: H B, Salvesen, O E, Iversen, L A, Akslen

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(11)

For patients with localized endometrial carcinoma at primary operation, there is a definite need for more specific prognostic parameters to select patients for adjuvant therapy. The purpose of this study was to evaluate the applicability and prognost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e776d37ee4d168f1d21f4b294c90f755
https://pubmed.ncbi.nlm.nih.gov/9829742

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Poorer survival of nulliparous women with endometrial carcinoma

Autor: H B, Salvesen, L A, Akslen, G, Albrektsen, O E, Iversen

Publikováno v: Cancer. 82(7)

Several epidemiologic studies have shown an inverse relationship between parity and the incidence of endometrial carcinoma. A prognostic influence of reproductive factors has been reported for carcinomas of the breast and uterine cervix; but no such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39010c37576bf1b1fcc347e37b2fee9b
https://pubmed.ncbi.nlm.nih.gov/9529025

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