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Akademický článek

Single‐cell transcriptomics reveals a senescence‐associated IL‐6/CCR6 axis driving radiodermatitis

Autor: Mor Paldor, Orr Levkovitch‐Siany, Dana Eidelshtein, Revital Adar, Claes D Enk, Yitzhak Marmary, Sharona Elgavish, Yuval Nevo, Hadar Benyamini, Inbar Plaschkes, Shiri Klein, Alex Mali, Stefan Rose‐John, Amnon Peled, Eithan Galun, Jonathan H Axelrod

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 8, Pp 1-20 (2022)

Abstract Irradiation‐induced alopecia and dermatitis (IRIAD) are two of the most visually recognized complications of radiotherapy, of which the molecular and cellular basis remains largely unclear. By combining scRNA‐seq analysis of whole skin�

Externí odkaz: https://doaj.org/article/5a050c8736134d50b74c2fbb8dbbdcf4

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Akademický článek

Hyper-Interleukin-6 Protects Against Renal Ischemic-Reperfusion Injury—A Mouse Model

Autor: Mohammad Zuaiter, Jonathan H. Axelrod, Galina Pizov, Ofer N. Gofrit

Publikováno v: Frontiers in Surgery, Vol 8 (2021)

Background: Most of the ischemia-reperfusion injury (IR-I) occurs during reperfusion and is mediated by the immune system. In this study we determined whether immunomodulation with hyper-Interleukin-6 (a recombinant designer cytokine composed of inte

Externí odkaz: https://doaj.org/article/e30921af889a463192f7d4c16edc39f8

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Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL6 trans-signaling

Publikováno v: Journal of Hepatology, 77(6), 1631-1641. Elsevier Science

BACKGROUND AND AIMS: Primary liver cancers include: Hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (CCA) and combined HCC-CCA tumors (cHCC-CCA). It has been suggested, but not unequivocally proven, that hepatic progenitor cells (HPCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35f9f989208ee8547dd302a2d0a5adb
https://cris.maastrichtuniversity.nl/en/publications/d57c548d-5429-4934-8f7c-86ffde92aab1

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Supplementary Materials and Methods from Multiple Roles of IL6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis

Autor: Jonathan H. Axelrod, Eithan Galun, Stefan Rose-John, Amnon Peled, Rifaat Safadi, Yuval Nevo, Sharona Elgavish, Orit Pappo, Nofar Rosenberg, Rinat Abramovitch, Dana Eidelshtein, Orr Levkovitch-Siany, Amir Sonnenblick, Tali Lanton, Anat Shriki

Supplemental Experimental Materials and Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81fc4a47d77318ade6e0a47fb3a2311
https://doi.org/10.1158/0008-5472.22428169

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Supplementary Data from Multiple Roles of IL6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis

Supplemental Figures and Tables

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46789b8367352cccbb762df245bf897e
https://doi.org/10.1158/0008-5472.22428175.v1

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Data from Multiple Roles of IL6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis

Hepatocellular carcinoma (HCC) typically develops on a background of chronic hepatitis for which the proinflammatory cytokine IL6 is conventionally considered a crucial driving factor. Paradoxically, IL6 also acts as a hepatoprotective factor in chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e751caead2222020afd96ce235c42f8
https://doi.org/10.1158/0008-5472.c.6512938.v1

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Supplementary Table 1, Supplementary Figures 1 through 9, and Supplementary Materials and Methods from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation

Autor: Jonathan H. Axelrod, Eithan Galun, Stefan Rose-John, Bruce J. Baum, Carmit Orfaig-Geva, Lina Mizrachi, Ron Eliashar, Jonathan Cohen, Alexander Maly, Annette Wygoda, Svetlana Gaska, Revital Adar, Yitzhak Marmary

Supplementary Table S1 - Patient Characteristics Supplementary Fig. S1 - IR-induced morphology and inflammatory responses Supplementary Fig. S2 - Apoptosis following IR Supplementary Fig. S3 - Morphology, Aquaporin and ??H2AX in Acini following IR Su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76751e003edde9373306d77f0073bfae
https://doi.org/10.1158/0008-5472.22410120.v1

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Data from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation

Head and neck cancer patients treated by radiation commonly suffer from a devastating side effect known as dry-mouth syndrome, which results from the irreversible loss of salivary gland function via mechanisms that are not completely understood. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689faf4fd1b83e55e6a379cfe5f392d5
https://doi.org/10.1158/0008-5472.c.6507918.v1

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Elektronická kniha

You Don't Have to Do It Alone : How to Involve Others to Get Things Done

Autor: Richard H. Axelrod, Emily M. Axelrod, Julie Beedon, Robert W. Jacobs

We all need to involve others to accomplish tasks and achieve our goals, but all too often involving others seems like more trouble than it's worth. You Don't Have to Do It Alone Alone is the Swiss Army Knife of involvement—a set of tools that can

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