Zobrazeno 1 - 10
of 34
pro vyhledávání: '"H. Alexander Ebhardt"'
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-5 (2018)
Abstract Developing combination therapy for castrate-resistant prostate cancer (CRPC) may require exploiting new drug targets outside androgen receptor and PI3K / AKT / mTOR signal transduction pathways implicated in prostate cancer (PCa) progression
Externí odkaz:
https://doaj.org/article/669b0c9cf68e49eb941bd529a663c812
Autor:
Rosalia Grande, Melania Dovizio, Simone Marcone, Paulina B. Szklanna, Annalisa Bruno, H. Alexander Ebhardt, Hilary Cassidy, Fionnuala Ní Áinle, Anna Caprodossi, Paola Lanuti, Marco Marchisio, Geltrude Mingrone, Patricia B. Maguire, Paola Patrignani
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Rationale: Obesity is a risk factor for atherothrombosis and various cancers. However, the mechanisms are not yet completely clarified.Objectives: We aimed to verify whether the microparticles (MPs) released from thrombin-activated platelets differed
Externí odkaz:
https://doaj.org/article/6d7e099b74d74b9aaf8873d2be5b2e59
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
How genetic diversity generates complex phenotypes along a continuum remains a fundamental question of biology. Here—applying the emerging SWATH proteomics technology—the authors describe a proteome wide association study (PWAS) of Drosophila win
Externí odkaz:
https://doaj.org/article/26a12fcbe96549b5a1836c3af3924120
Autor:
Carolyn A. Greig, H. Alexander Ebhardt, Valentina Tadini, Ruedi Aebersold, Simone Degen, Carsten Jacobi, Alain Schilb, Kenneth C. H. Fearon, Neil Johns
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle. 8:567-582
Background Cancer cachexia (cancer-induced muscle wasting) is found in a subgroup of cancer patients leaving the patients with a poor prognosis for survival due to a lower tolerance of the chemotherapeutic drug. The cause of the muscle wasting in the
Autor:
Yansheng Liu, Jakub Faktor, Vendula Paralova, Hana Imrichova, Lenka Čápková, H. Alexander Ebhardt, Roman Hrstka, Ruedi Aebersold, Eva Budinská, Pavel Bouchal, Karolina Zoufalova, Rudolf Nenutil, Olga T. Schubert
Publikováno v:
Cell Reports
Cell Reports, 28 (3)
Cell Reports, Vol 28, Iss 3, Pp 832-843.e7 (2019)
Cell Reports, 28 (3)
Cell Reports, Vol 28, Iss 3, Pp 832-843.e7 (2019)
Summary Accurate classification of breast tumors is vital for patient management decisions and enables more precise cancer treatment. Here, we present a quantitative proteotyping approach based on sequential windowed acquisition of all theoretical fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db9fd29e9be31fbdcfe46d7f8515667
https://doi.org/10.1101/583443
https://doi.org/10.1101/583443
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 17, Iss 1, Pp 1-5 (2018)
Molecular Cancer, Vol 17, Iss 1, Pp 1-5 (2018)
Developing combination therapy for castrate-resistant prostate cancer (CRPC) may require exploiting new drug targets outside androgen receptor and PI3K / AKT / mTOR signal transduction pathways implicated in prostate cancer (PCa) progression. One suc
Publikováno v:
Proteomics
Biological systems are composed of numerous components of which proteins are of particularly high functional significance. Network models are useful abstractions for studying these components in context. Network representations display molecules as n
Publikováno v:
Rapid Communications in Mass Spectrometry
RATIONALE Tandem mass (MS/MS) spectra generated by collision-induced dissociation (CID) typically lack redundant peptide sequence information in the form of e.g. b- and y-ion series due to frequent use of sequence-specific endopeptidases cleaving C-
Publikováno v:
Nature Communications
Nature Communications, 7
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications, 7
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The manner by which genetic diversity within a population generates individual phenotypes is a fundamental question of biology. To advance the understanding of the genotype–phenotype relationships towards the level of biochemical processes, we perf
Autor:
Yifeng Liu, Richard P. Fahlman, H. Alexander Ebhardt, Herbert H. Tsang, Babak Bostan, Denny C. Dai
Publikováno v:
Nucleic Acids Research
Recent advances in DNA-sequencing technology have made it possible to obtain large datasets of small RNA sequences. Here we demonstrate that not all non-perfectly matched small RNA sequences are simple technological sequencing errors, but many hold v