Zobrazeno 1 - 10
of 162
pro vyhledávání: '"H. A. Martens"'
Autor:
C. D. Popa, H. A. Martens
Publikováno v:
ACR Open Rheumatology, Vol 5, Iss 6, Pp 287-287 (2023)
Externí odkaz:
https://doaj.org/article/a32aadc261dd4e619d83f91f7cec6976
Autor:
Jason P. Wray, Elitza M. Deltcheva, Charlotta Boiers, Simon Е Richardson, Jyoti Bikram Chhetri, John Brown, Sladjana Gagrica, Yanping Guo, Anuradha Illendula, Joost H. A. Martens, Hendrik G. Stunnenberg, John H. Bushweller, Rachael Nimmo, Tariq Enver
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The ETV6-RUNX1 chimeric- and native RUNX1-responsive regulomes in paediatric B-acute lymphoblastic leukemia (B-ALL) remain to be characterized. Here, the authors reveal functional antagonism between the two transcription factors predominantly for the
Externí odkaz:
https://doaj.org/article/57a324404a3a49c69acb08a4d571d807
Autor:
B. M. H. Heuts, S. Arza-Apalategi, S. Frölich, S. M. Bergevoet, S. N. van den Oever, S. J. van Heeringen, B. A. van der Reijden, J. H. A. Martens
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Advanced computational methods exploit gene expression and epigenetic datasets to predict gene regulatory networks controlled by transcription factors (TFs). These methods have identified cell fate determining TFs but require large amounts o
Externí odkaz:
https://doaj.org/article/08eea22203854069872faba1a598c883
Autor:
Nunzio Del Gaudio, Antonella Di Costanzo, Ning Qing Liu, Lidio Conte, Carmela Dell’Aversana, Guglielmo Bove, Rosaria Benedetti, Liliana Montella, Fortunato Ciardiello, Vincenzo Carafa, Concetta Ambrosino, Valeria Tucci, Mariarosaria Conte, Joost H. A. Martens, Hendrik G. Stunnenberg, Angela Nebbioso, Lucia Altucci
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovered chromatin readers i
Externí odkaz:
https://doaj.org/article/07529a4a602742c3a53ad8261632a83c
Autor:
Olivier B. Bakker, Aarón D. Ramírez-Sánchez, Zuzanna A. Borek, Niek de Klein, Yang Li, Rutger Modderman, Yvonne Kooy-Winkelaar, Marie K. Johannesen, Filomena Matarese, Joost H. A. Martens, Vinod Kumar, Jeroen van Bergen, Shuo-Wang Qiao, Knut E. A. Lundin, Ludvig M. Sollid, Frits Koning, Cisca Wijmenga, Sebo Withoff, Iris H. Jonkers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Celiac disease is an auto-immune disease in which an immune response to dietary gluten leads to inflammation and subsequent atrophy of small intestinal villi, causing severe bowel discomfort and malabsorption of nutrients. The major instigat
Externí odkaz:
https://doaj.org/article/66b9019aaac7432d846ad8c14c396c51
Autor:
Sandra Cantilena, Luca Gasparoli, Deepali Pal, Olaf Heidenreich, Jan‐Henning Klusmann, Joost H. A. Martens, Alexandre Faille, Alan J. Warren, Mawar Karsa, Ruby Pandher, Klaartje Somers, Owen Williams, Jasper de Boer
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 6, Pp n/a-n/a (2022)
Abstract Background Improving the poor prognosis of infant leukaemias remains an unmet clinical need. This disease is a prototypical fusion oncoprotein‐driven paediatric cancer, with MLL (KMT2A)‐fusions present in most cases. Direct targeting of
Externí odkaz:
https://doaj.org/article/1c1567bc09014df8bcc740417102afeb
Autor:
Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga, Jan Jacob Schuringa
Publikováno v:
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflict
Externí odkaz:
https://doaj.org/article/bc991f9e636e41c6936e5e05d890d9b1
Autor:
Lotte E. Tholen, Femke Latta, Joost H. A. Martens, Joost G. J. Hoenderop, Jeroen H. F. de Baaij
Publikováno v:
American Journal of Physiology : Renal Physiology, 324, F211-F224
American Journal of Physiology : Renal Physiology, 324, 2, pp. F211-F224
American Journal of Physiology : Renal Physiology, 324, 2, pp. F211-F224
Genetic defects in transcription factor hepatocyte nuclear factor (HNF)1β cause a heterogeneous disease characterized by electrolyte disturbances, kidney cysts, and diabetes. By combining RNA-sequencing and HNF1β chromatin immunoprecipitation-seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84f6716ea8e14138b66eab2a8a67ef1
https://doi.org/10.1152/ajprenal.00199.2022
https://doi.org/10.1152/ajprenal.00199.2022
Autor:
Esther Tijchon, Guoqiang Yi, Amit Mandoli, Jos G A Smits, Francesco Ferrari, Branco M H Heuts, Falco Wijnen, Bowon Kim, Eva M Janssen-Megens, Jan Jacob Schuringa, Joost H A Martens
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226435 (2019)
Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect normal hematopoiesis. The analysis of human AMLs has mostly been performed using end-point materials, such as cell lines and patient derived AMLs that also carry additio
Externí odkaz:
https://doaj.org/article/c2d8cbfea6314d7495286f1c3efb457d
Autor:
Branco Heuts, Saioa Arza-Apalategi, Sinna Alkema, Esther Tijchon, Laura Jussen, Saskia Bergevoet, Bert van der Reijden, Joost H. A. Martens
A t(9;11)(p22;q23) translocation produces the MLL-AF9 fusion protein, which is found in up to 25% of de novo AML cases in children. Despite major advances, obtaining a comprehensive understanding of context-dependent MLL-AF9-mediated gene programs du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af6664e2950a51ae1d66deb9b6d711c1
https://doi.org/10.21203/rs.3.rs-2521405/v1
https://doi.org/10.21203/rs.3.rs-2521405/v1
