Výsledky vyhledávání - "H. A. Karnes"

Comparison of a stable isotope labeled (SIL) peptide and an extended SIL peptide as internal standards to track digestion variability of an unstable signature peptide during quantification of a cancer biomarker, human osteopontin, from plasma using capillary microflow LC–MS/MS

Autor: Matthew S. Halquist, Morse Faria, Rand Jenkins, William Mylott, H. Thomas Karnes, Moucun Yuan

Publikováno v: Journal of Chromatography B. 1001:156-168

Human osteopontin (hOPN) is a secreted plasma protein which is elevated in various cancers and is indicative of poor prognosis. Here we describe investigations involving an extended peptide internal standard to track an unstable signature peptide fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1053f49c84d3a91c888eef05064ddb0
https://doi.org/10.1016/j.jchromb.2015.05.040

Zobrazit plný text záznamu

Pulmonary delivery of anorectic oxyntomodulin in rats: food intake suppression, reduced body weight gain and pharmacokinetics

Autor: Masahiro Sakagami, Matthew S. Halquist, Priya P Nadkarni, Richard M. Costanzo, H. Thomas Karnes

Publikováno v: Therapeutic Delivery. 6:297-306

Background: Oxyntomodulin (OXM1–37) is an anorectic gut-secreting peptide with a promise to treat obesity, but its needle-free delivery has yet to be successful. Results: Pulmonary delivery of OXM1–37, but not its C-terminal octapeptides, caused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8bcc08fdb08184daff4485177c57af
https://doi.org/10.4155/tde.14.117

Zobrazit plný text záznamu

Safety studies of post-surgical buprenorphine therapy for mice

Autor: Nadine Forbes-McBean, Rachel Sarabia-Estrada, Karl A Traul, Cory Brayton, Matthew S. Halquist, Michael J Tomlinson, H. Thomas Karnes, Patricia L. Zadnik, Jennell B Romero, Louis J. DeTolla, Xiaobu Ye, Michael Guarnieri, Betty Tyler

Publikováno v: Laboratory Animals. 49:100-110

The use of appropriate analgesia in laboratory mice may be suboptimal because of concerns about adverse events (AE). Target Animal Safety trials were conducted to determine the safety of an extended-release suspension of buprenorphine. Drug or contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efca04878be8174043aac2e14180f6a2
https://doi.org/10.1177/0023677214554216

Zobrazit plný text záznamu

An extended stable isotope-labeled signature peptide internal standard for tracking immunocapture of human plasma osteopontin for LC-MS/MS quantification

Autor: William Mylott, Matthew S. Halquist, Moucun Yuan, Morse Faria, H. Thomas Karnes, Rand Jenkins

Publikováno v: Biomedical Chromatography. 29:1780-1782

A stable isotope-labeled signature peptide, whose sequence corresponds to the human osteopontin (hOPN) specific antibody epitope, was evaluated as an internal standard to compensate for immunocapture variability during quantification of hOPN by immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d346ccb032d56048adc87ee3cd618c13
https://doi.org/10.1002/bmc.3471

Zobrazit plný text záznamu

SELECTIVITY INVESTIGATION AND LIQUID CHROMATOGRAPHIC METHOD FOR THE ANALYSIS OF NICOTINE IN TOBACCO EXTRACTS

Autor: Poonam R. Delvadia, H. Thomas Karnes

Publikováno v: Journal of Liquid Chromatography & Related Technologies. 36:1849-1868

A simple and selective high performance liquid chromatographic (HPLC) method for the analysis of nicotine in a Hanks' balanced salts extract of smokeless tobacco components is presented here. An HPLC method was modified and applied for the analysis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::899148b205774a826f0e23200dbca26f
https://doi.org/10.1080/10826076.2012.704607

Zobrazit plný text záznamu

Plný text ve formátu HTML

Investigation of endogenous blood lipids components that contribute to matrix effects in dried blood spot samples by liquid chromatography-tandem mass spectrometry

Autor: Rand Jenkins, H. Thomas Karnes, Omnia A. Ismaiel

Publikováno v: Drug Testing and Analysis. 5:710-715

Dried blood spot (DBS) sampling coupled to liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a rapidly developing approach in the field of biopharmaceutical analysis. DBS sampling enables analysis of small sample volumes with high sensitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9807cbd0b15a3e9eaf13155eb5f1f7a6
https://doi.org/10.1002/dta.1421

Zobrazit plný text záznamu

Evaluation of the Effect of Ammonia on Nicotine Pharmacokinetics Using Rapid Arterial Sampling

Autor: William H. Barr, Gerd Kobal, Kelly Fisher, Diana Mckinney, W. Hans Carter, Maria Gogova, Viswanathan Ramakrishnan, Bruce D. Davies, William R. Garnett, Sunil S. Iyer, H. Thomas Karnes, Amit A. Somani

Publikováno v: Nicotine & Tobacco Research. 14:586-595

INTRODUCTION: The nicotine bolus theory states that the dependence-producing potential of cigarettes relates to a rapid increase in nicotine at brain receptor sites. It has been suggested that ammonia, a compound typically found in tobacco products,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1dc3a03e65a0140f8434e3596c448dc
https://doi.org/10.1093/ntr/ntr257

Zobrazit plný text záznamu

Monitoring cellular accumulation of 3′-deoxy-3′-fluorothymidine (FLT) and its monophosphate metabolite (FLT-MP) by LC–MS/MS as a measure of cell proliferation in vitro

Autor: Marcela Araya, Peter J. O'Brien, Matthew S. Halquist, Phillip M. Gerk, Elliott Mark Leonard, H. Thomas Karnes, Cathy Zhang, Wenlin Li, Xiaolin Kang

Publikováno v: Journal of Chromatography B. 879:2963-2970

Accurate measurement of in vitro cell growth is critical for oncology drug development, but cell counting and the most accurate indirect proliferation assays are impractical. Here, we describe a robust alternative method that monitors proliferating c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e7913bc0bc5cfcc6831c0d3519213d
https://doi.org/10.1016/j.jchromb.2011.08.024

Zobrazit plný text záznamu

Direct analysis of dried blood spots by in-line desorption combined with high-resolution chromatography and mass spectrometry for quantification of maple syrup urine disease biomarkers leucine and isoleucine

Autor: John H. Miller, H. Thomas Karnes, Philip A. Poston

Publikováno v: Analytical and Bioanalytical Chemistry. 400:237-244

A in-line desorption device was developed, which allows for direct analysis of dried blood spots eliminating the need for punching disks from the filter paper cards. Using this device, we have validated a method to quantify biomarkers related to mapl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4558f6816738afc72c65b66500bd6b4
https://doi.org/10.1007/s00216-011-4740-x

Zobrazit plný text záznamu

Diazepam autoinjector intramuscular delivery system versus diazepam rectal gel: A pharmacokinetic comparison

Autor: William R. Garnett, H. Thomas Karnes, William H. Barr, Gerald L. Wannarka, Mike Mesa, Leslie Edinboro

Publikováno v: Epilepsy Research. 93:11-16

Rectal administration of diazepam (DZ) has been used effectively in patients with epilepsy who experience acute repetitive seizures, but rectal gel may be difficult to administer during a seizure and is subject to variable drug absorption. An intramu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89484b55fde2b1c6cd3888267cf79d82
https://doi.org/10.1016/j.eplepsyres.2010.10.001

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání