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Akademický článek

Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag

Autor: Ellen H. Brumbaugh-Reed, Yang Gao, Kazuhiro Aoki, Jared E. Toettcher

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Biomolecular condensates are broadly implicated in both normal cellular regulation and disease. Consequently, several chemical biology and optogenetic approaches have been developed to induce phase separation of a protein of interest. Howeve

Externí odkaz: https://doaj.org/article/2734a9f4aa924704ae35e1798669302a

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Akademický článek

pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells

Autor: Payam E Farahani, Xiaoyu Yang, Emily V Mesev, Kaylan A Fomby, Ellen H Brumbaugh-Reed, Caleb J Bashor, Celeste M Nelson, Jared E Toettcher

Publikováno v: eLife, Vol 12 (2023)

Receptor tyrosine kinases (RTKs) are major signaling hubs in metazoans, playing crucial roles in cell proliferation, migration, and differentiation. However, few tools are available to measure the activity of a specific RTK in individual living cells

Externí odkaz: https://doaj.org/article/d80e6707678348058feb76df9128ca69

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Lessons Learned in the Transformation of a Multispecialty Medical Group to a Management Services Organization Supporting Multiple Service Lines

Autor: H Lester Reed, Chad Hoyt, Jeremy Hardison, Dani Madril

Publikováno v: Physician Leadership Journal. 9:24-28

A 30% growth of providers within the multispecialty Centra Medical Group’s health system was associated with increasing operational costs, inefficiencies of incentivized production, and poor alignment around the Quadruple Aim. Clinical services and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8714def8ab8a6b389793bea9687858fb
https://doi.org/10.55834/plj.8913182966

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