Zobrazeno 1 - 10
of 167
pro vyhledávání: '"H. -R. Olpe"'
Autor:
D.L Dawack, E. Ngo Bum, A Rakotonirina, S.V Rakotonirina, A. Jeker, Markus Schmutz, P Herrling, H. R. Olpe, C. Portet
Publikováno v:
Fitoterapia. 75:309-314
The decoction of Mimosa pudica leaves given intraperitoneally at dose of 1000-4000 mg/kg protected mice against pentylentetrazol and strychnine-induced seizures. M. pudica had no effect against picrotoxin-induced seizures It also antagonized N-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69618845f47dc002c3625684566376ff
https://doi.org/10.1016/j.fitote.2004.01.012
https://doi.org/10.1016/j.fitote.2004.01.012
Publikováno v:
Neuroscience. 117:681-695
The mode of action of the antipsychotic drugs clozapine, haloperidol and iloperidone was investigated in layer V of prefrontal cortex slices using extracellular field potential, intracellular sharp-electrode as well as whole-cell voltage clamp record
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b0968abc57fc32672a6bcd39da0960
https://doi.org/10.1016/s0306-4522(02)00769-8
https://doi.org/10.1016/s0306-4522(02)00769-8
Publikováno v:
Epilepsia. 35:S47-S50
Summary: Oxcarbazepine (OCBZ, Trileptal) and its main human monohydroxy metabolite (MHD) protected mice and rats against generalized tonic-clonic seizures induced by electroshock with ED50 values between 13.5 and 20.5 mg/kg p.o. No tolerance toward t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fd3403168f669963f493f6b535b9ae2
https://doi.org/10.1111/j.1528-1157.1994.tb05967.x
https://doi.org/10.1111/j.1528-1157.1994.tb05967.x
Autor:
Stuart J. Mickel, Grety Rihs, Roger Graham Hall, P. C. Waldmeier, Conrad Gentsch, G. Von Sprecher, J. Jaekel, Helmut Bittiger, P. A. Baumann, Wolfgang Froestl, H. R. Olpe, Dietrich Strub, Felix Brugger, Annick Vassout
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::204bdc116be98cddced44ef913593f8e
https://doi.org/10.1002/chin.199551214
https://doi.org/10.1002/chin.199551214
Publikováno v:
Experientia. 48:748-751
The aim of this study was to investigate the putative role of GABAB receptors in the development of amygdala kindling in rats. The effects of the GABAB blocker CGP 35348 and the GABAB agonist baclofen on the progressive development of behavioural sei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413a248ad6faac44c0fc887b3dab433d
https://doi.org/10.1007/bf02124293
https://doi.org/10.1007/bf02124293
Publikováno v:
Experientia. 47:254-257
The exact mode of action of the anti-epileptic agent carbamazepine is unknown. In hippocampal slices in which epileptiform discharges were induced by addition of penicillin to the perfusion medium, the depressant effect of carbamazepine was attenuate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e41260c5ae32350b0adb5b7fafd8006
https://doi.org/10.1007/bf01958152
https://doi.org/10.1007/bf01958152
Autor:
H.-R. Olpe, Wolfgang Froestl, Mario F. Pozza, Roger Graham Hall, Martin W. Steinmann, Helmut Bittiger, Graham E. Fagg, H. van Riezen, Felix Brugger, Göril Karlsson
Publikováno v:
European Journal of Pharmacology. 187:27-38
The biochemical, electrophysiological and pharmacological properties of the new GABAB receptor blocker CGP 35348 are described. In a variety of receptor binding assays CGP 35348 showed affinity for the GABAB receptor only. CGP 35348 had an IC50 of 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0777479ba34440e818833ed11dce9d
https://doi.org/10.1016/0014-2999(90)90337-6
https://doi.org/10.1016/0014-2999(90)90337-6
Autor:
C. Portet, H. R. Olpe, Roland Heckendorn, Annick Vassout, Graham E. Fagg, H. van Riezen, A. Jeker, Klaus Klebs, Hans Allgeier, Markus Schmutz
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 342:61-66
Anticonvulsant properties of CGP 37849 and CGP 39551, two novel phosphono-amino acids which are competitive NMDA receptor antagonists, were examined in rodents. At optimal pretreatment times CGP 37849 suppressed electroshock-induced seizures in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1350672ad50f807ac29be663f0a839cd
https://doi.org/10.1007/bf00178973
https://doi.org/10.1007/bf00178973
Autor:
Mario F. Pozza, C. Portet, H. Allgeier, John Grey Dr Dingwall, G.E. Fagg, Christof Angst, M. Schmutz, J. Baud, Helmut Bittiger, H.-R. Olpe, P. A. Baumann, Martin W. Steinmann, K. Thedinga, Roland Heckendorn, Derek E. Brundish
Publikováno v:
British Journal of Pharmacology. 99:791-797
1 The pharmacological properties of CGP 37849 (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid; 4-methyl-APPA) and its carboxyethylester, CGP 39551, novel unsaturated analogues of the N-methyl-D-aspartate (NMDA) receptor antagonist, 2-amino-5-ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35561589fda90727cb68d9f952ae2d16
https://doi.org/10.1111/j.1476-5381.1990.tb13008.x
https://doi.org/10.1111/j.1476-5381.1990.tb13008.x
Publikováno v:
Journal of ethnopharmacology. 95(2-3)
Extracts from rhizomes of Cyperus articulatus L. (Cyperaceae) used in Africa and Amazonia to treat many diseases has been shown to possess sedative and anticonvulsant properties. The aim of this study is to determine the mechanism of action of Cyperu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b21de02831cd21c8176510356832e3
https://pubmed.ncbi.nlm.nih.gov/15507353
https://pubmed.ncbi.nlm.nih.gov/15507353