Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

Autor: Knut H Lauritzen, Maria Belland Olsen, Mohammed Shakil Ahmed, Kuan Yang, Johanne Egge Rinholm, Linda H Bergersen, Qin Ying Esbensen, Lars Jansen Sverkeli, Mathias Ziegler, Håvard Attramadal, Bente Halvorsen, Pål Aukrust, Arne Yndestad

Publikováno v: eLife, Vol 10 (2021)

Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD+) as energy source. Prolonged PARP activity can drain cellular NAD+ reserves, leading to de-regulation of important molecular

Externí odkaz: https://doaj.org/article/156b773902e04f898047b04a65716854

Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets

Autor: Catherine J. Jackson, Sjur Reppe, Jon R. Eidet, Lars Eide, Kim A. Tønseth, Linda H. Bergersen, Darlene A. Dartt, May Griffith, Tor P. Utheim

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Abstract Cultured epidermal cell sheets (CES) containing undifferentiated cells are useful for treating skin burns and have potential for regenerative treatment of other types of epithelial injuries. The undifferentiated phenotype is therefore import

Externí odkaz: https://doaj.org/article/e3d6a4a77a904c098d096051ac614af9

Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP

Autor: Nina Vardjan, Helena H. Chowdhury, Anemari Horvat, Jelena Velebit, Maja Malnar, Marko Muhič, Marko Kreft, Špela G. Krivec, Saša T. Bobnar, Katarina Miš, Sergej Pirkmajer, Stefan Offermanns, Gjermund Henriksen, Jon Storm-Mathisen, Linda H. Bergersen, Robert Zorec

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Besides being a neuronal fuel, L-lactate is also a signal in the brain. Whether extracellular L-lactate affects brain metabolism, in particular astrocytes, abundant neuroglial cells, which produce L-lactate in aerobic glycolysis, is unclear. Recent s

Externí odkaz: https://doaj.org/article/eccf9693d6d643ec98be6c24d4620e27

Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

Autor: Emilie R Glesaaen, Lauritz Kennedy, Vuk Palibrk, Marco Pannone, Wei Wang, Ali Al-Jabri, Rajikala Suganthan, Niklas Meyer, Marie Landa Austbø, Xiaolin Lin, Linda H Bergersen, Magnar Bjørås, Johanne E Rinholm

Publikováno v: eLIFE
Kennedy, L, Glesaaen, E R, Palibrk, V, Pannone, M, Wang, W, Al-Jabri, A, Suganthan, R, Meyer, N, Austbø, M L, Lin, X, Bergersen, L H, Bjørås, M & Rinholm, J E 2022, ' Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia ', eLife, vol. 11 . https://doi.org/10.7554/eLife.76451

Neonatal cerebral hypoxia-ischemia (HI) is the leading cause of death and disability in newborns with the only current treatment being hypothermia. An increased understanding of the pathways that facilitate tissue repair after HI may aid the developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c773080441a74a019f581608f2029dc
http://hdl.handle.net/10852/98302

Hippocampal Adult Neurogenesis Is Maintained by Neil3-Dependent Repair of Oxidative DNA Lesions in Neural Progenitor Cells

Autor: Christine Elisabeth Regnell, Gunn Annette Hildrestrand, Yngve Sejersted, Tirill Medin, Olve Moldestad, Veslemøy Rolseth, Silje Zandstra Krokeide, Rajikala Suganthan, Luisa Luna, Magnar Bjørås, Linda H. Bergersen

Publikováno v: Cell Reports, Vol 2, Iss 3, Pp 503-510 (2012)

Accumulation of oxidative DNA damage has been proposed as a potential cause of age-related cognitive decline. The major pathway for removal of oxidative DNA base lesions is base excision repair, which is initiated by DNA glycosylases. In mice, Neil3

Externí odkaz: https://doaj.org/article/2db3587bde7c4ee5a797f4931f5d4fc3