Prognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patients

Autor: S. T. Paijens, A. Vledder, D. Loiero, E. W. Duiker, J. Bart, A. M. Hendriks, M. Jalving, H. H. Workel, H. Hollema, N. Werner, A. Plat, G. B. A. Wisman, R. Yigit, H. Arts, A. J. Kruse, N.M. de Lange, V. H. Koelzer, M. de Bruyn, H. W. Nijman

Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)

CD103-positive tissue resident memory-like CD8+ T cells (CD8CD103 TRM) are associated with improved prognosis across malignancies, including high-grade serous ovarian cancer (HGSOC). However, whether quantification of CD8, CD103 or both is required t

Externí odkaz: https://doaj.org/article/4818c953f2ba48078fb49ed6224cdb2a

Ovarian colorectal metastases: peritoneal or hematogeneous metastatic disease?

Autor: M. Leimkühler, P.H.J. Hemmer, N. Werner, I.H.J.T. de Hingh, M.J.E. Mourit, H. Hollema, G.H. de Bock, B.L. van Leeuwen

PurposeThere is an ongoing discussion whether ovarian colorectal metastases are the result of peritoneal or hematogeneous dissemination. The metastatic route has implications on the choice of treatment. This study aims to evaluate and discuss the fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f4db7e7ccdd4a9b1bde822643840d8b
https://doi.org/10.21203/rs.3.rs-1684313/v1

Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer

Autor: H. Hollema, M.A.T.M. van Vugt, Gert Jan Meersma, A.G.J. van der Zee, S de Jong, Nicolette G. Alkema, Marieke Everts, Tushar Tomar, G. B. A. Wisman

Publikováno v: Gynecologic Oncology, 133(3), 591-598. ACADEMIC PRESS INC ELSEVIER SCIENCE

Objective. Platinum-based chemotherapy is the standard treatment in advanced stage high grade serous ovarian cancer (HGSOC), but the majority of patients will relapse with drug-resistant disease. Platinum induces double-strand DNA breaks and subseque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8936ed94cc999277ddf4eb10c8f79c7c
https://doi.org/10.1016/j.ygyno.2014.03.557

POSTER VIEWING SESSION - MALE AND FEMALE FERTILITY PRESERVATION

Autor: N. Akakubo, N. Kagawa, A. Yabuuchi, S. J. Silber, S. Yamaguchi, Y. Nagumo, Y. Takai, S. Ishihara, Y. Takehara, O. Kato, J. Kocent, J. C. Y. Hu, Q. V. Neri, Z. Rosenwaks, G. D. Palermo, G. Armuand, K. Rodriguez-Wallberg, L. Wettergren, C. Lampic, J. C. Martinez-Soto, J. C. Domingo, B. Cordovilla, J. Gadea, J. Landeras, H. Sadri-Ardekani, M. M. Akhondi, F. van der Veen, D. G. de Rooij, S. Repping, A. M. M. van Pelt, J. Vanacker, V. Luyckx, M. M. Dolmans, C. A. Amorim, A. Van Langendonckt, J. Donnez, A. Camboni, M. Gavella, V. Lipovac, Z. Siftar, V. Garaj-Vrhovac, G. Gajski, D. Gook, J. Borg, D. H. Edgar, J. J. Brink-van der Vlugt, V. H. J. Van der Velden, A. Noordijk, H. Timmer-Bosscha, W. J. E. Tissing, J. A. Land, H. Hollema, J. Van Echten-Arends, J. G. Alvarez, A. Gosalvez, E. Velilla, M. Lopez-Teijon, C. Lopez-Fernandez, J. Gosalvez, S. G. Kristensen, A. Rasmussen, C. Yding Andersen, A. Raziel, S. Friedler, Y. Gidoni, I. Ben Ami, S. Kaufman, A. Omansky, D. Strassburger, D. Komarovsky, O. Bern, E. Kasterstein, A. Komsky, B. Maslansky, R. Ron-El, A. Fujimoto, Y. Osuga, M. Ichinose, H. Oishi, M. Harada, M. Koizumi, Y. Takemura, T. Yano, Y. Taketani, Z. Molnar, A. Mokanszki, M. Benyo, Z. Bazsane Kassai, E. Olah, A. Jakab, K. A. Rodriguez-Wallberg, E. Vonheim, E. Gumus, I. Persson, M. Lundqvist, P. O. Karlstrom, O. Hovatta, F. F. Pasqualotto, R. Teixeira, G. S. Medeiros, C. Canabarro, J. Tonezer, A. P. C. Grando, E. Borges Jr., E. B. Pasqualotto, J. R. Westphal, L. Bastings, C. C. M. Beerendonk, D. D. M. Braat, R. Peek, B. Courbiere, A. Berthelot-Ricou, C. Di Giorgio, M. De Meo, A. Roustan, A. Botta, J. Perrin, R. Abir, R. Orvieto, O. Friedman, A. Ben-Haroush, B. Fisch, B. Lawrenz, J. Henes, M. Henes, E. Neunhoeffer, M. Schmalzing, T. Fehm, I. Koetter

Publikováno v: Human Reproduction. 26:i248-i256

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbe806849e4f4d037f2f576f4bfd7a0c
https://doi.org/10.1093/humrep/26.s1.84

Expression of P-glycoprotein, multidrug resistance-associated protein 1, and lung resistance-related protein in human soft tissue sarcomas before and after hyperthermic isolated limb perfusion with tumor necrosis factor-alpha and melphalan

Autor: R, Komdeur, B E, Plaat, H J, Hoekstra, W M, Molenaar, H, Hollema, E, van den Berg, M F, Mastik, W T, van der Graaf

Publikováno v: Cancer. 91(10):1940-1948

BACKGROUND. Multidrug resistance (MDR) is associated with expression of P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), and lung resistance-related protein (LRP). Tumor necrosis factor (TNF-alpha) is able to modify the expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::765117b39c2411d7b4fea6bb14360f09
https://hdl.handle.net/11370/0c2608e8-50a0-40a4-b545-3e31c16f1e40