Zobrazeno 1 - 10
of 40
pro vyhledávání: '"H W, Ruelius"'
Publikováno v:
Xenobiotica. 17:1437-1449
1. The first step in the interaction between oxaprozin glucuronide and human serum albumin (HSA) is formation of a reversible complex which then leads to the following reactions; (a) acyl migration of the aglycone from position 1 to positions 2, 3 an
Publikováno v:
Clinical Pharmacology & Therapeutics. 12:468-481
Publikováno v:
Experientia. 29:653-655
Die Glucuronide des Oxazepams und Lorazepams wurden aus dem Harn von Zwergschweinen, denen die entsprechenden Benzodiazepine verabreicht wurden, isoliert. Die Metaboliten wurden durch Analyse der Spaltprodukte gekennzeichnet. Massenspektrometrie der
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 214(3)
The antihypertensive agent guanabenz (E-2,6-dichlorobenzylidene aminoguanidine acetate. Wy-8678) was administered i.v. in single doses of 10, 32 and 100 microgram/kg to groups of spontaneously hypertensive rats. Mean arterial blood pressure and heart
Publikováno v:
Advances in experimental medicine and biology. 197
Hydrolysis and rearrangement (isomerization by acyl migration) of oxaprozin glucuronide are greatly accelerated by plasma and human serum albumin. Albumin accounts for all the hydrolytic activity in plasma and no esterase is involved. The isomeric es
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 4(6)
The renal clearance of 1-aminocyclohexanecarboxylic acid (ACHC), a metabolite of the semisynthetic penicillin, cyclacillin, is about 10 times faster in female than in male rats. The slower clearance in males is attributed to a higher net rate of reab
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 7(1)
Oxazepam glucuronide isolated from swine urine by previously published methods was separated into its diastereoisomers by ion-exchange chromatography on a preparative scale. Quantitative high-performance liquid chromatography was used to monitor the
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 10(6)
The concentrations of (R)-(-)- and (S)-(+)-oxazepam glucuronides in plasma and urine of several species have been measured. The relative amounts of these diastereoisomers vary among species. Thus, in the plasma and urine of rhesus monkeys the concent
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 2(1)
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 9(4)
1. Absorption of a single oral dose of [14C]iprindole was rapid in rats, rhesus monkeys, miniature swine, dogs and human volunteers. In all species except the rat, most of the radioactivity in the blood resided in the plasma. Small amounts of unchang