Zobrazeno 1 - 10
of 42
pro vyhledávání: '"H W, Krell"'
Publikováno v:
APOPTOSIS. 7:217-220
The effect of synthetic inhibitors of matrix metalloproteinases (MMP) has been shown against a variety of tumors in preclinical models. Ro 28-2653, a novel synthetic MMP inhibitor, is able to reduce tumor growth in orthotopic prostatic cancer in rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffaec88167a9429c861016ca36c9e777
https://doi.org/10.1023/a:1015383231080
https://doi.org/10.1023/a:1015383231080
Autor:
D. Trautmann, Anja A. Kühl, H.-W. Krell, Markus M. Heimesaat, Christoph Loddenkemper, Britta Siegmund, Andre Fischer, D. Fuchs, A. Batra, Oliver Liesenfeld, Ildiko Rita Dunay, Stefan Bereswill
In the experimental models of intestinal inflammation and humans with inflammatory bowel diseases (IBD), increased levels of the matrix metalloproteinases (MMPs), MMP-2 and -9 (also referred to as gelatinase A and B, respectively), in inflamed tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b8bd53f2f04eb02c0f24885da212c3
https://europepmc.org/articles/PMC3906619/
https://europepmc.org/articles/PMC3906619/
Autor:
Boris Böll, Venkateswara R. Simhadri, H.-W. Krell, E. P. Von Strandmann, K. Wiegmann, Vijaya Lakshmi Simhadri, A. Chalaris, Stefan Rose-John, Dennis A. Eichenauer, Hinrich P. Hansen, Katrin S. Reiners, A. M. Vahdat, Andreas Engert
Publikováno v:
Leukemia. 24(1)
Combinations with proteasome inhibitors are currently being investigated to improve the therapy of hematological malignancies. We previously found that proteasome inhibition by bortezomib failed to sensitize anti-CD30 antibody (Ab)-based lymphoma cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfb2531f72e1fb352ac5142b25d38a3
https://pubmed.ncbi.nlm.nih.gov/19890373
https://pubmed.ncbi.nlm.nih.gov/19890373
Autor:
Markus Weiler, Huatao Huang, Ghazaleh Tabatabai, Ulrike Naumann, Wolfgang Wick, U. Hohlweg, H. W. Krell, Hiroko Ohgaki, M. Weller, Johannes Rieger, Oliver Bähr
Publikováno v:
Cell death and differentiation. 13(7)
Conditionally BCL-xL-overexpressing LNT-229 Tet-On glioma cell clones were generated to investigate whether the 'antiapoptosis phenotype' and the 'motility phenotype' mediated by BCL-2 family proteins in glioma cells could be separated. BCL-xL induct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0d68e09e46dd888664c522d0a0798a
https://pubmed.ncbi.nlm.nih.gov/16254573
https://pubmed.ncbi.nlm.nih.gov/16254573
Autor:
C. R. Sommerhoff, P. Roesken, N. Dagdelen, C. Volkering, Okan Safak, A. Botzlar, H. W. Krell, A. Pfadenhauer, W. Mutschier
Publikováno v:
Zurück in die Zukunft ISBN: 9783540200024
Proteasen, und hierbei insbesondere die Gruppe der Matrix-Metalloproteasen (MMPs), sind in allen Phasen der Wundheilung masgeblich an Gewebeumbau-Prozessen beteiligt. Eine Storung des Gleichgewichtes zwischen MMPs und ihren endogenen Inhibitoren den
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f44b09403357f01673c7824dca3de0f0
https://doi.org/10.1007/978-3-642-55611-1_436
https://doi.org/10.1007/978-3-642-55611-1_436
Autor:
H. W. Krell, A. Pfadenhauer, F. Roesken, C. Volkering, A. Botzlar, Okan Safak, Christian P. Sommerhoff, N. Dagdelen, W. Mutschler
Publikováno v:
Deutsche Gesellschaft für Chirurgie ISBN: 9783540006596
Increased proteinase activity seems to be mainly responsible for impaired healing in chronic wounds. Topical application of matrix metalloproteinase (MMPs) inhibitors, with the objective to reestablish the physiological MMP/TIMP (tissue inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::359fdc1f583644b8396f3f86e44e2391
https://doi.org/10.1007/978-3-642-19024-7_64
https://doi.org/10.1007/978-3-642-19024-7_64
Publikováno v:
Apoptosis : an international journal on programmed cell death. 7(3)
The effect of synthetic inhibitors of matrix metalloproteinases (MMP) has been shown against a variety of tumors in preclinical models. Ro 28-2653, a novel synthetic MMP inhibitor, is able to reduce tumor growth in orthotopic prostatic cancer in rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d17671bcddd5faa625696a99d44cf87
https://pubmed.ncbi.nlm.nih.gov/11997665
https://pubmed.ncbi.nlm.nih.gov/11997665
Pyrimidine-2,4,6-Triones: A New Effective and Selective Class of Matrix Metalloproteinase Inhibitors
Autor:
F, Grams, H, Brandstetter, S, D'Alò, D, Geppert, H W, Krell, H, Leinert, V, Livi, E, Menta, A, Oliva, G, Zimmermann, F, Gram, E, Livi VMenta
Publikováno v:
Biological Chemistry. 382
Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that have been implicated in various disease processes. Different classes of MMP inhibitors, including hydroxamic acids, phosphinic acids and thiols, have been previously described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b5b7992074398f8ef740a9d5e62a00
https://doi.org/10.1515/bc.2001.159
https://doi.org/10.1515/bc.2001.159
Publikováno v:
Anticancer research. 19(5B)
Many studies have highlighted the role played by matrix metalloproteinases MMP-2 and -9, by serine proteases uPA and plasmin in tumor cell invasion. This study investigates the impact of the MMP-inhibitor Batimastat and/or the serine protease inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c144d0f0d0c0643b4154b4e3b5b2b378
https://pubmed.ncbi.nlm.nih.gov/10628317
https://pubmed.ncbi.nlm.nih.gov/10628317
Autor:
Carine Munaut, Jean-Michel Foidart, Frank Grams, H. W. Krell, Alain Colige, Francis Frankenne, Erik Maquoi, Agnès Noël, Charles Lambert
Publikováno v:
Annals of the New York Academy of Sciences. 878
Due to their unusual ability to cleave and degrade a variety of ECM components, including triple-helical type IV collagen, two members of the family of matrix metalloproteinases (MMPs), MMP-2 and MMP-9, are thought to play critical roles during tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5780d7c074c5657cad9c4ac1bb00eea
https://pubmed.ncbi.nlm.nih.gov/10415825
https://pubmed.ncbi.nlm.nih.gov/10415825