Zobrazeno 1 - 10
of 11
pro vyhledávání: '"H W, Culp"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 20(6)
Gemcitabine, 2'-deoxy-2',2'-difluorocytidine, is a broad spectrum oncolytic compound with antitumor activity in solid tumor models. The pharmacokinetics, metabolism, and disposition of gemcitabine was examined in mice, rats, and dogs. All three speci
Autor:
C. N. Rice, H. W. Culp
Publikováno v:
Endocrinology. 67:563-569
Tetraiodothyroformic-3',5'I2131 acid was administered intraperitoneally to male rats. The drug was metabolized by the animal and excreted in the bile. Chromatographic and hydrolytic procedures indicated the single metabolite to be the ester glucuroni
Publikováno v:
Chemischer Informationsdienst. 11
Publikováno v:
Cancer research. 37(9)
The excretion, blood levels, and tissue distribution of [3H]vindesine have been studied in the rat. After an i.v. administration of 500 microgram/kg. [3H]vindesine was found to be distributed very rapidly to tissues. After the distribution phase, blo
Autor:
M J, Sweeney, G B, Boder, G J, Cullinan, H W, Culp, W D, Daniels, R W, Dyke, K, Gerzon, R E, McMahon, R L, Nelson, G A, Poore, G C, Todd
Publikováno v:
Cancer research. 38(9)
Publikováno v:
Diabetes. 16(2)
The metabolism of acetohexamide was studied in normal and diabetic subjects,utilizing acetohexamide-C-14 and hydroxyhexamide-C-14 in two types of experiments. In one, blood levels were determined by an isotopic dilution analysis (IDA). In the other,
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 149(3)
Autor:
H W, Culp, R E, McMahon
Publikováno v:
The Journal of biological chemistry. 243(4)
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 149(2)
Publikováno v:
Antimicrobial agents and chemotherapy. 161