Zobrazeno 1 - 4
of 4
pro vyhledávání: '"H W, Christinger"'
Autor:
S G, Hymowitz, H W, Christinger, G, Fuh, M, Ultsch, M, O'Connell, R F, Kelley, A, Ashkenazi, A M, de Vos
Publikováno v:
Molecular cell. 4(4)
Formation of a complex between Apo2L (also called TRAIL) and its signaling receptors, DR4 and DR5, triggers apoptosis by inducing the oligomerization of intracellular death domains. We report the crystal structure of the complex between Apo2L and the
Publikováno v:
Journal of molecular biology. 293(4)
The Fab portion of a humanized antibody (Fab-12; IgG form known as rhuMAb VEGF) to vascular endothelial growth factor (VEGF) has been affinity-matured through complementarity-determining region (CDR) mutation, followed by affinity selection using mon
Publikováno v:
Journal of molecular biology. 293(3)
The extracellular portion of the VEGF and PlGF receptor, Flt-1 (or VEGFR-1), consists of seven immunoglobulin-like domains. The second domain from the N terminus (Flt-1D2) is necessary and sufficient for high affinity VEGF binding. The 1.7 A resoluti
Autor:
H W, Christinger, Y A, Muller, L T, Berleau, B A, Keyt, B C, Cunningham, N, Ferrara, A M, de Vos
Publikováno v:
Proteins. 26(3)
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor with a unique specificity for vascular endothelial cells. In addition to its role in vasculogenesis and embryonic angiogenesis, VEGF is implicated in pathologic neovascularizatio