Výsledky vyhledávání - "H Van den Elst"

A study on the use of phenylacetyl disulfide in the solid-phase synthesis of oligodeoxynucleoside phosphorothioates

Autor: H. C. P. F. Roelen, Paul C. J. Kamer, J. H. Van Boom, H. Van Den Elst, G. A. Van Der Marel

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 110:325-331

Sulfurization of protected [i.e., 2-cyanoethyl, methyl and 2-(4-nitrophenyl)ethyl] internucleosidic phosphite triesters can be conveniently executed with the easily accessible reagent, phenylacetyl disulfide (1). High-quality oligodeoxynucleotides co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4f34853888584176aa91853953ae70f
https://doi.org/10.1002/recl.19911100705

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Synthesis of fragments of the capsular polysaccharide of Haemophilus influenzae type b: Part IIII-3. A solid-phase synthesis of a spacer-containing ribosylribitol phosphate hexamer

Autor: H. J. Muntendam, J. H. Van Boom, G. A. Van Der Marel, H. Van Den Elst, P. Hoogerhout, C. J. J. Elie

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 108:219-223

A solid-phase synthesis of an aminohexyl-containing hexameric fragment of the H. influenzae type b capsular polysaccharide, using a phosphoramidite approach and controlled-pore glass as the solid support, is reported.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0c70e68533d0a48effb19a2e8fbf957
https://doi.org/10.1002/recl.19891080604

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Preparation of internucleotide phosphate analogues via the corresponding H-phosphonate diester

Autor: E. De Vroom, G. A. Van Der Marel, H. Van Den Elst, J. H. Van Boom, C. E. Dreef

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 107:592-595

Silylation of a H-phosphonate diester with N, O-bis(trimethylsilyl)acetamide or tert-butyldimethylsilyl chloride affords 3′,5′-internucleotidic phosphite triester intermediates. Arbusow reaction of the latter compounds with appropriate halogenide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc7b89eb438d5b0b448a3c2f508ad145
https://doi.org/10.1002/recl.19881071004

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Solid-phase synthesis of oligodeoxynucleotides containing 4-alkoxythymidine residues

Autor: H. Van Den Elst, G. A. Van Der Marel, J. H. Van Boom, H. F. Brugghe, H. C. P. F. Roelen

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 111:99-104

Immobilized and fully protected oligodeoxynucleotides containing a 4-(1,2,4-triazolyl)-thymidine residue at a predetermined position were prepared according to a well-established phosphite triester methodology using 2-cyanoethyl phosphoramidites of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::398d8019bdb4f81de159c752e26f62ee
https://doi.org/10.1002/recl.19921110207

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Solid-phase synthesis of RNA via a silyl-protecting-group strategy

Autor: C.M. Dreef-Tromp, E. M. A. van Dam, J. H. Van Boom, H. Van Den Elst, G. A. Van Der Marel, J. E. van den Boogaart

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 110:378-383

Ribonucleoside phosphoramidites have been prepared of which the exocyclic amino functions and 2′-hydroxyl functions are protected with 2-[(tert-butyldiphenylsiloxy)methyl]benzoyl groups and tert-butyldimethylsilyl groups, respectively. The N-SiOMB/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8adddfff2c8d8e2827912298810d0a28
https://doi.org/10.1002/recl.19911100905

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Solid-phase synthesis of oligodeoxynucleotides containing 6-O-alkylguanosines

Autor: H. C. P. F. Roelen, J. C. Klein, H. F. Brugghe, H. Van Den Elst, J. H. Van Boom, G. A. Van Der Marel

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 111:227-234

High-quality oligodeoxynucleotides having an 6-O-alkyl-2′-deoxyguanosine (alkyl = methyl, ethyl, n-propyl or n-hexyl) residue at a predetermined position can be obtained via a solid-phase approach using the respective 2-cyanoethyl N,N-diisopropylph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b17b3337e48fcf5f8658b7c459dc68f3
https://doi.org/10.1002/recl.19921110505

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Synthesis of oligodeoxynucleotides containing thymidines linked via an internucleosidic-(3′-5′)-methylene bond

Autor: G. H. Veeneman, H. Van Den Elst, J. H. Van Boom, G. A. Van Der Marel

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 109:449-451

Condensation of N3-benzoyl-5′-O-dimethoxytrityl-3′-O-(4-penten-1-oxymethyl)-thymidine with N3-benzoyl-3′-O-methoxyacctyl-thymidine, in the presence of N-iodosuccinimide, afforded a fully-protected thymidine dimer having an internucleosidic-(3�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fa0bfb4b0278086522d1a858608dc2c
https://doi.org/10.1002/recl.19901090712

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Conformational Aspects of an Uncharged Phosphate Analogon Built In at the Branch-point of a DNA Four-way Junction

Autor: Franc J.J Overmars, H. Van Den Elst, C. M. Dreef-Tromp, Jeroen A. Pikkemaat, J. H. Van Boom, C. Altona

Publikováno v: Journal of Molecular Biology. 262:349-357

Electrostatic interactions appear to be important in the conformation and dynamics of DNA four-way junctions. Particularly, the Coulomb repulsion between two approaching phosphate groups at the site of strand exchange is commonly supposed to have a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b2e0e891dfbb72816a2a051b429e44
https://doi.org/10.1006/jmbi.1996.0518

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