Zobrazeno 1 - 10
of 20
pro vyhledávání: '"H U, Shetty"'
Publikováno v:
Neurochemical Research. 27:1641-1647
Until recently, brain phospholipid metabolism was thought to consume only 2% of the ATP consumed by the mammalian brain as a whole. In this paper, however, we calculate that 1.4% of total brain ATP consumption is consumed for the de novo synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2cea6a06c1c9e01d328044379c1f925
https://doi.org/10.1023/a:1021635027211
https://doi.org/10.1023/a:1021635027211
Publikováno v:
Clinical Chemistry. 42:298-302
Previous studies suggest the presence of increased concentrations of cerebral myo-inositol in Alzheimer disease (AD). To characterize this abnormality further, we quantified myo-inositol and several other polyols in cerebrospinal fluid (CSF) and plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e622ae27c13c393aab440fa3ef05957d
https://doi.org/10.1093/clinchem/42.2.298
https://doi.org/10.1093/clinchem/42.2.298
Autor:
Nigel H. Greig, H U Shetty, Timothy T. Soncrant, S. I. Rapoport, Quentin R. Smith, Seiji Momma
Publikováno v:
Cancer Chemotherapy and Pharmacology. 26:263-268
Unidirectional blood-brain barrier transfer of the lipophilic anticancer agents vincristine and vinblastine was studied in anesthetized rats, using an isolated, in situ brain perfusion technique. Drug binding to plasma constituents was also measured.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05b0b80988e9834e0e7444dbf9a34c4
https://doi.org/10.1007/bf02897227
https://doi.org/10.1007/bf02897227
Publikováno v:
Biochemical Journal. 313:31-33
myo-Inositol and several other polyols were measured in the tissues of the trisomy 16 mouse (animal model of Down's Syndrome; human trisomy 21) and diploid controls. myo-Inositol was found to be selectively elevated in the brain of the trisomy 16 mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634d0a6217b2b66c2ad9f54a1fb11d5c
https://doi.org/10.1042/bj3130031
https://doi.org/10.1042/bj3130031
Publikováno v:
Neurochemical research. 27(12)
Until recently, brain phospholipid metabolism was thought to consume only 2% of the ATP consumed by the mammalian brain as a whole. In this paper, however, we calculate that 1.4% of total brain ATP consumption is consumed for the de novo synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::002cea61077277f36a1fa0a231748a50
https://pubmed.ncbi.nlm.nih.gov/12515317
https://pubmed.ncbi.nlm.nih.gov/12515317
Autor:
Mark B. Schapiro, Wei Huang, Gene E. Alexander, L. Chang, S. I. Rapoport, H U Shetty, Jack S. Krasuski
Publikováno v:
Neurology. 57(4)
Objective: 1 H-MRS studies have shown abnormalities in brain levels of myo -inositol (mI) and N -acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined. The authors sought to determine whether al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e495ab3bd5120001d9cf771e01adb6
https://pubmed.ncbi.nlm.nih.gov/11524470
https://pubmed.ncbi.nlm.nih.gov/11524470
Publikováno v:
Neurochemical research. 25(4)
myo-Inositol is elevated in the Down syndrome (DS; trisomy 21) brain and may play a role in mental retardation. In the present study, we examined brain regions and peripheral tissues of Ts65Dn mouse, a recently characterized genetic model of DS, for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00cfaf7eb512ee5e673d07052150a0e9
https://pubmed.ncbi.nlm.nih.gov/10823574
https://pubmed.ncbi.nlm.nih.gov/10823574
Autor:
D. Hill, Takao Hayakawa, Michael C. J. Chang, G. Grimes, A. D. Purdon, H. U. Shetty, C. Connolly
Publikováno v:
Life sciences. 63(20)
Recent studies from our laboratory have shown that methyl palmoxirate (MEP), an inhibitor of mitochondrial beta-oxidation of long chain fatty acids, can be used to increase incorporation of radiolabeled palmitic acid into brain lipids and reduce beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d13bc998d9f7b0b8d287dda36b86a4
https://pubmed.ncbi.nlm.nih.gov/9820128
https://pubmed.ncbi.nlm.nih.gov/9820128
Publikováno v:
Journal of mass spectrometry : JMS. 32(4)
A gas chromatographic (GC)/mass spectrometric method for studying myo-inositol uptake by neurons in vitro is described. Cultured cortical neurons from fetuses of diploid and trisomy 16 mouse (animal model for Down syndrome) were incubated with a phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a33ed9060b9e3a1894e5384b66b6066
https://pubmed.ncbi.nlm.nih.gov/9130398
https://pubmed.ncbi.nlm.nih.gov/9130398
Publikováno v:
Journal of neurochemistry. 67(4)
In vivo rates of arachidonic acid incorporation and turnover were determined for molecular species of rat brain phosphatidylcholine (PtdCho) and phosphatidylinositol (Ptdlns). [ 3 H]Arachidonic acid was infused intravenously in pentobarbital-anesthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fa194ba1fcdb1a2083b9fd0b61ae69
https://pubmed.ncbi.nlm.nih.gov/8858956
https://pubmed.ncbi.nlm.nih.gov/8858956