Zobrazeno 1 - 10
of 22
pro vyhledávání: '"H U, Göringer"'
Autor:
H. U. Göringer, Leeder Wm
Publikováno v:
Methods in Molecular Biology ISBN: 9781071602300
Mitochondrial pre-mRNAs in African trypanosomes adopt intricately folded, highly stable 2D and 3D structures. The RNA molecules are substrates of a U-nucleotide-specific insertion/deletion-type RNA editing reaction, which is catalyzed by a 0.8 MDa pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a5a72e82696f7307c12de90b3039b10
https://doi.org/10.1007/978-1-0716-0231-7_10
https://doi.org/10.1007/978-1-0716-0231-7_10
Autor:
M Homann, H U Göringer
Publikováno v:
Nucleic Acids Research. 27:2006-2014
African trypanosomiasis is a parasitic disease caused by a specific class of protozoan organisms. The best-studied representative of that group is Trypanosoma brucei which is transmitted by tsetse flies and multiplies in the blood of many mammals. Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfd1adf03fd6d89b7cd3f58dba71b79
https://doi.org/10.1093/nar/27.9.2006
https://doi.org/10.1093/nar/27.9.2006
Trypanosoma brucei mitochondrial ribonucleoprotein complexes which contain 12S and 9S ribosomal RNAs
Autor:
H. H. Shu, H. U. Göringer
Publikováno v:
Parasitology. 116:157-164
Antibiotics have been widely used to identify ribosomal activity in Trypanosoma brucei mitochondria. The validity of some of the results has been questioned because the permeability of the trypanosome cell membrane for some antibiotics was not adequa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f87e4bc93ab5599b541e0da402b5d4
https://doi.org/10.1017/s0031182097002023
https://doi.org/10.1017/s0031182097002023
Publikováno v:
Molecular and Cellular Biology. 14:2629-2639
RNA editing in kinetoplastids probably employs a macromolecular complex, the editosome, that is likely to include the guide RNAs (gRNAs) which specify the edited sequence. Specific ribonucleoprotein (RNP) complexes which form in vitro with gRNAs (H.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1e9fdd24bb8a11b1cc677ab3f05686
https://doi.org/10.1128/mcb.14.4.2629-2639.1994
https://doi.org/10.1128/mcb.14.4.2629-2639.1994
Publikováno v:
Proceedings of the National Academy of Sciences. 91:1776-1780
Transcripts from mitochondrial (maxicircle) genes of kinetoplastid organisms undergo RNA editing characterized by a series of reactions that insert and delete uridine nucleotides within the sequence of the pre-mRNAs. Guide RNAs, which complement full
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af4cc4ca46550bede7c1169b0f733c9
https://doi.org/10.1073/pnas.91.5.1776
https://doi.org/10.1073/pnas.91.5.1776
Publikováno v:
RNA and DNA editing: Methods and protocols
Methods in molecular biology
RNA and DNA Editing ISBN: 9781617790171
Methods in molecular biology
RNA and DNA Editing ISBN: 9781617790171
RNA editing within the mitochondria of kinetoplastid protozoa is performed by a multicomponent -macromolecular machine known as the editosome. Editosomes are high molecular mass protein assemblies that consist of about 15-25 individual polypeptides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8be91cb88e428ca0edacb1d25b20bb1
https://hdl.handle.net/11858/00-001M-0000-0027-C302-811858/00-001M-0000-0011-568E-4
https://hdl.handle.net/11858/00-001M-0000-0027-C302-811858/00-001M-0000-0011-568E-4
Publikováno v:
Nucleic Acids Research. 20:4221-4227
A series of base substitution and deletion mutations were constructed in the highly conserved 530 stem and loop region of E. coli 16S rRNA involved in binding of tRNA to the ribosomal A site. Base substitution and deletion of G517 produced significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4102e5b4918dd225305eb95f13fde831
https://doi.org/10.1093/nar/20.16.4221
https://doi.org/10.1093/nar/20.16.4221
Autor:
Catherine D. Prescott, H U Göringer
Publikováno v:
Nucleic Acids Research. 18:5381-5386
A single base change in 16S rRNA (C726 to G) has previously been shown to have a dramatic effect on protein synthesis in E. coli (1). This paper more specifically details the effects of the mutation on mRNA binding and translation-termination. The in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299c28c160e21282926708508df92839
https://doi.org/10.1093/nar/18.18.5381
https://doi.org/10.1093/nar/18.18.5381
Publikováno v:
Nucleic Acids Research. 18:6271-6275
Hybrid promoter constructs were used to determine the DNA sequence requirements for stringent and growth rate control within a promoter region. The promoters were obtained by fusing complementing sequence regions located upstream and downstream from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41ca8bc5251677f28b475d6e98ef282
https://doi.org/10.1093/nar/18.21.6271
https://doi.org/10.1093/nar/18.21.6271
Publikováno v:
Handbook of experimental pharmacology. (173)
Protozoal pathogens cause symptomatic as well as asymptomatic infections. They have a worldwide impact, which in part is reflected in the long-standing search for antiprotozoal chemotherapy. Unfortunately, effective treatments for the different disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3c1bd0584a7f3b5ed93fcd05458624a
https://pubmed.ncbi.nlm.nih.gov/16594626
https://pubmed.ncbi.nlm.nih.gov/16594626