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Akademický článek

Resistance exercise in early-stage ALS patients, ALSFRS-R, Sickness Impact Profile ALS-19, and muscle transcriptome: a pilot study

Autor: Omar Jawdat, Jason Rucker, Tomoki Nakano, Kotaro Takeno, Jeffery Statland, Mamatha Pasnoor, Mazen M. Dimachkie, Carla Sabus, Yomna Badawi, Suzanne L. Hunt, Naoko H. Tomioka, Sumedha Gunewardena, Clark Bloomer, Heather M. Wilkins, Laura Herbelin, Richard J. Barohn, Hiroshi Nishimune

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract Amyotrophic lateral sclerosis (ALS) patients lack effective treatments to maintain motor and neuromuscular function. This study aimed to evaluate the effect of a home-based exercise program on muscle strength, ALS scores, and transcriptome i

Externí odkaz: https://doaj.org/article/e3237184e1bb4c6f98062c0787594ebf

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Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations

Autor: Yu Toyoda, Hiroshi Miyata, Naohiro Uchida, Keito Morimoto, Ryuichiro Shigesawa, Hidetoshi Kassai, Kazuki Nakao, Naoko H. Tomioka, Hirotaka Matsuo, Kimiyoshi Ichida, Makoto Hosoyamada, Atsu Aiba, Hiroshi Suzuki, Tappei Takada

Publikováno v: Pflügers Archiv - European Journal of Physiology. 475:489-504

Uric acid, the end product of purine metabolism in humans, is crucial because of its anti-oxidant activity and a causal relationship with hyperuricemia and gout. Several physiologically important urate transporters regulate this water-soluble metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77c0216cab96d7c901b099c1b97e3450
https://doi.org/10.1007/s00424-023-02792-1

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Akademický článek

Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice

Autor: Naoko Morimura, Hiroki Yasuda, Kazuhiko Yamaguchi, Kei-ichi Katayama, Minoru Hatayama, Naoko H. Tomioka, Maya Odagawa, Akiko Kamiya, Yoshimi Iwayama, Motoko Maekawa, Kazuhiko Nakamura, Hideo Matsuzaki, Masatsugu Tsujii, Kazuyuki Yamada, Takeo Yoshikawa, Jun Aruga

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Lrfn2/SALM1 is a synaptic adhesion molecule, and is known to interact with PSD-95. Here the authors show that Lrfn2 regulates excitatory synapse maturation and maintenance, and that Lrfn2 knockout mice exhibit autism-like behaviours as well as enhanc

Externí odkaz: https://doaj.org/article/1acb992c3c7f417085fb67cf1cfeb33b

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Akademický článek

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Akademický článek

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Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice

Autor: Shigeru Shibata, Koji Matsumoto, Naoko H. Tomioka, Takuji Hosoya, Shunya Uchida, Makoto Hosoyamada

Publikováno v: Journal of the American Society of Nephrology. 33:326-341

Background Hereditary renal hypouricemia type-1 (RHUC1) is caused by URAT1/SLC22A12 dysfunction, resulting in urolithiasis and exercise-induced acute kidney injury (EIAKI). Because, however, there is no useful experimental RHUC1 animal model, the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6361a9c2c62ad553de8590f6f7163639
https://doi.org/10.1681/asn.2021050616

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Akademický článek

Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor against Pathophysiological Decline of Lung Function

Publikováno v: Antioxidants, Vol 9, Iss 5, p 387 (2020)

The oxidant/antioxidant imbalance plays a pivotal role in the lung. Uric acid (UA), an endogenous antioxidant, is highly present in lung tissue, however, its impact on lung function under pathophysiological conditions remains unknown. In this work, p

Externí odkaz: https://doaj.org/article/a1b150bf3848422eb2fba666b5aeeeac

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