Zobrazeno 1 - 10
of 41
pro vyhledávání: '"H Teal"'
Autor:
Xizhang Sun, Jinoh Kim, Nikita S. Kolhatkar, Edward A. Clark, Matthew B. Buechler, Craig P. Chappell, Keith B. Elkon, Lena Tanaka, Thereza Imanishi-Kari, Natalia V. Giltiay, Jessica A. Hamerman, Thomas H. Teal, Alice E. Wiedeman
Publikováno v:
The Journal of Experimental Medicine
Transgenic expression of TLR7 results in the expansion and hyperactivation of T1 B cells in response to endogenous RNA complexes, leading to increased autoantibody production.
Toll-like receptor (TLR), a ligand for single-stranded RNA, has been
Toll-like receptor (TLR), a ligand for single-stranded RNA, has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5328468f1736fcc1295756d1ad47c4db
https://doi.org/10.1084/jem.20122798
https://doi.org/10.1084/jem.20122798
Increased Ribonuclease Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice
Autor:
Jessica A. Hamerman, Jeffrey A. Ledbetter, Nalini Agrawal, Thomas H. Teal, Denny Liggitt, Charles E. Alpers, Matthew B. Buechler, Lena Tanaka, Kelly L. Hudkins, Xizhang Sun, Keith B. Elkon, Alice E. Wiedeman, Silvia Bolland
Publikováno v:
The Journal of Immunology. 190:2536-2543
TLR7 activation is implicated in the pathogenesis of systemic lupus erythematosus. Mice that overexpress TLR7 develop a lupus-like disease with autoantibodies and glomerulonephritis and early death. To determine whether degradation of the TLR7 ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28023e6f1ab801f1b07e90265f621e57
https://doi.org/10.4049/jimmunol.1202689
https://doi.org/10.4049/jimmunol.1202689
Publikováno v:
The Journal of Immunology. 190:886-891
Mice overexpressing TLR7 (TLR7.1 mice) are a model of systemic lupus erythematosus pathogenesis and exhibit peripheral myeloid expansion. We show that TLR7.1 mice have a dramatic expansion of splenic cells that derive from granulocyte/macrophage prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5d881ededf7493ac952728eed5bc45
https://doi.org/10.4049/jimmunol.1202739
https://doi.org/10.4049/jimmunol.1202739
Autor:
A. V. S. Hill, D. J. Weatherall, J. S. Wainscoat, Helena Ayyub, Robert D. Nicholls, Douglas R. Higgs, J. B. Clegg, H. Teal
Although alpha thalassaemia is rare in north Europeans, it has been identified in British people with no known foreign ancestry. Twelve such patients were studied, of whom eight shared a distinctive molecular defect, which was clearly different from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cb35e41391e30850de4e32ed72a8d1
https://doi.org/10.1136/bmj.290.6478.1303
https://doi.org/10.1136/bmj.290.6478.1303
Autor:
Gillian I. Rice, Tracy A Briggs, Keith B. Elkon, Laura Durcan, Joshua J. Woodward, Thomas H. Teal, Reynold M. Karr, Jie An
Publikováno v:
An, J, Durcan, L, Karr, R M, Briggs, T A, Rice, G I, Teal, T H, Woodward, J J & Elkon, K B 2017, ' Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus ', Arthritis & rheumatology (Hoboken, N.J.), vol. 69, no. 4, pp. 800-807 . https://doi.org/10.1002/art.40002
Objective Type I interferon (IFN) is implicated in the pathogenesis of systemic lupus erythematosus (SLE) and interferonopathies such as Aicardi-Goutieres syndrome. A recently discovered DNA-activated type I IFN pathway, cyclic GMP-AMP synthase (cGAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a476df1a314ccbbba400396fcb8bf931
https://pubmed.ncbi.nlm.nih.gov/27863149
https://pubmed.ncbi.nlm.nih.gov/27863149
Publikováno v:
The Journal of Immunology
Immune complexes (ICs) play a pivotal role in causing inflammation in systemic lupus erythematosus (SLE). Yet, it remains unclear what the dominant blood cell type(s) and inflammation-related gene programs stimulated by lupus ICs are. To address thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d73fda023fc2af8a45596c46d33035
https://doi.org/10.4049/jimmunol.1102797
https://doi.org/10.4049/jimmunol.1102797
Autor:
Matthew B. Frieman, Matthew D. Dyer, Ralph S. Baric, Gregory A. Zornetzer, Thomas H. Teal, Judith M. A. van den Brand, Bart L. Haagmans, Michael G. Katze, Sean Proll, Tracey Baas, Timothy P. Sheahan, Barry Rockx
Publikováno v:
Journal of Virology
Journal of Virology, 83(14), 7062-7074. American Society for Microbiology
Journal of Virology, 83(17), 9022-9022. American Society for Microbiology
Europe PubMed Central
Journal of Virology, 83(14), 7062-7074. American Society for Microbiology
Journal of Virology, 83(17), 9022-9022. American Society for Microbiology
Europe PubMed Central
Several respiratory viruses, including influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV), produce more severe disease in the elderly, yet the molecular mechanisms governing age-related susceptibility remain poorly studied.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab83b614e83c0d564c12ae12a3d52319
https://doi.org/10.1128/jvi.00127-09
https://doi.org/10.1128/jvi.00127-09
Autor:
Michael G. Katze, David A. Leib, Sean Proll, Betty Lu, Thomas H. Teal, Tracy Jo Pasieka, Cristian Cilloniz
Publikováno v:
Journal of Virology. 83:2075-2087
Humans and mice lacking the interferon signaling molecule Stat1 are sensitive to a variety of pathogens due to their presumed inability to mount a strong innate immune response. The herpes simplex virus type 1 (HSV-1) virion host shutoff (vhs) protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a27b42dd67efd6a9d4b60a2c9e2391a
https://doi.org/10.1128/jvi.02007-08
https://doi.org/10.1128/jvi.02007-08
Autor:
Jun Chen, Tracey Baas, Anjeanette Roberts, Kanta Subbarao, Leatrice Vogel, Terrence M. Tumpey, Michael G. Katze, Thomas H. Teal
Publikováno v:
Journal of Virology
The relationship between immunosenescence and the host response to virus infection is poorly understood at the molecular level. Two different patterns of pulmonary host responses to virus were observed when gene expression profiles from severe acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11fc104337a80f4b417f28799bc33ed
Autor:
Lonneke M. Leijten, Michael G. Katze, Tracey Baas, Brandon Rain, Albert D. M. E. Osterhaus, Anna de Lang, Bart L. Haagmans, Thomas H. Teal
Publikováno v:
PLoS Pathogens
PLoS Pathogens (print), 3(8), 1129-1141. Public Library of Science
PLoS Pathogens, Vol 3, Iss 8, p e112 (2007)
PLoS Pathogens (print), 3(8), 1129-1141. Public Library of Science
PLoS Pathogens, Vol 3, Iss 8, p e112 (2007)
The pathogenesis of severe acute respiratory syndrome coronavirus (SARS-CoV) is likely mediated by disproportional immune responses and the ability of the virus to circumvent innate immunity. Using functional genomics, we analyzed early host response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e0a8a0f7c159fa42a387bbf92a7418
https://doi.org/10.1371/journal.ppat.0030112
https://doi.org/10.1371/journal.ppat.0030112