Zobrazeno 1 - 10
of 195
pro vyhledávání: '"H T, Ho"'
Autor:
Charles Bayly-Jones, Bill H. T. Ho, Corinna Lau, Eleanor W. W. Leung, Laura D’Andrea, Christopher J. Lupton, Susan M. Ekkel, Hariprasad Venugopal, James C. Whisstock, Tom E. Mollnes, Bradley A. Spicer, Michelle A. Dunstone
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
The cryo-EM structure of monoclonal antibody aE11 bound to polyC9 reveals that the binding site within the Membrane Attack Complex is a quaternary discontinuous epitope formed by two separate surfaces of the oligomeric C9 periphery.
Externí odkaz:
https://doaj.org/article/96ef9aa75dd84880b13fa08f60261470
Autor:
Jeffery Ho, Hung Chan, Yonghao Liang, Xiaodong Liu, Lin Zhang, Qing Li, Yuchen Zhang, Judeng Zeng, Felix N. Ugwu, Idy H. T. Ho, Wei Hu, Johnny C. W. Yau, Sunny H. Wong, Wai Tat Wong, Lowell Ling, Chi H. Cho, Richard L. Gallo, Tony Gin, Gary Tse, Jun Yu, Matthew T. V. Chan, Czarina C. H. Leung, William K. K. Wu
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-16 (2020)
Abstract Objectives The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies
Externí odkaz:
https://doaj.org/article/7d62813e15f84a7bb7e67e903aed1b8b
Autor:
Yun Liu, Zeyao Zhu, Idy H. T. Ho, Yujian Shi, Jianzhen Li, Xia Wang, Matthew T. V. Chan, Christopher H. K. Cheng
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
MiR-430 is considered an important regulator during embryonic development, but genetic loss-of-function study is still lacking. Here we demonstrated that genetic deletion of the miR-430 cluster resulted in developmental defects in cell movement, germ
Externí odkaz:
https://doaj.org/article/fdab69c74fd8483fbb44e2c9e061dc23
Publikováno v:
Journal of Wound Care. 29:S23-S27
Objective: Tie-over dressing is the most frequently used technique of skin grafting. However, many deficiencies affecting the outcome have been reported. We hereby introduce a modified method, termed the ‘extra-wound fixation technique’, for skin
Autor:
William K.K. Wu, Idy H. T. Ho, Chee Sam Chan, Xiaojie Cheng, Matthew T. V. Chan, Lin Zhang, Lhotse H.L. Ng, Xiaodong Liu, Tony Gin, Lizu Xiao, Wuping Sun
Publikováno v:
Neurobiology of Pain, Vol 10, Iss, Pp 100071-(2021)
Neurobiology of Pain
Neurobiology of Pain
Highlights • ANXA2 is a novel MOR1-interacting protein regulating MOR1 sub-cellular localization. • ANXA2 retains MOR1 in late recycling endosomes after remifentanil exposure.
Autor:
Daniel R Scoles, Mi H T Ho, Warunee Dansithong, Lance T Pflieger, Lance W Petersen, Khanh K Thai, Stefan M Pulst
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128769 (2015)
Spinocerebellar ataxia type 2 (SCA2) is a progressive autosomal dominant disorder caused by the expansion of a CAG tract in the ATXN2 gene. The SCA2 disease phenotype is characterized by cerebellar atrophy, gait ataxia, and slow saccades. ATXN2 mutat
Externí odkaz:
https://doaj.org/article/440f5061fa9b48f2801e3eeb7e703aec
Autor:
Zheng Li, Idy H. T. Ho, Matthew T. V. Chan, Derong Xu, William K.K. Wu, Xingye Li, Xiaodong Liu, Shugang Li
Publikováno v:
Journal of Cellular and Molecular Medicine
Spinal cord injury (SCI) may lead to persistent locomotor dysfunction and somatosensory disorders, which adversely affect the quality of life of patients and cause a significant economic burden to the society. The efficacies of current therapeutic in
Autor:
Wei Hu, Xiaodong Liu, Xiaoting Chen, Matthew T. V. Chan, Idy H. T. Ho, Tony Gin, Chee Sam Chan, Shanglong Kou, Hung Chan, Jeffery Ho, Xiang Zhang, Yuanyuan Tian, Jun Yu, Sunny H. Wong, Lin Zhang, Xuegang Sun, William K.K. Wu
Publikováno v:
Journal of Cellular and Molecular Medicine
Impaired autophagic degradation of intracellular lipids is causally linked to the development of non‐alcoholic steatohepatitis (NASH). Pharmacological agents that can restore hepatic autophagic flux could therefore have therapeutic potentials for t
Autor:
Xinluan Wang, Jiang Yue, Shihui Chen, Nianye Zheng, Idy H. T. Ho, Jiankun Xu, Ri Zhang, Hao Yao, Ling Qin, Xiaodong Liu, Jiali Wang
Publikováno v:
The Spine Journal. 18:2112-2118
BACKGROUND CONTEXT Cervical radicular pain resulting from mechanical compression of a spinal nerve secondary to spinal degenerative alternations negatively impacts patients’ quality of life. Jingshu Keli (JSKL), a traditional Chinese medicine formu
Autor:
Yingzhi Liu, Yidan Zou, Lin Zhang, Maggie Haitian Wang, Qingpeng Zhang, Zheng Li, Hung Chan, Xiaoxu Hu, Idy H. T. Ho, Tony Gin, Dan Huang, Yan Wang, Qing Li, Jianxiong Shen, Jun Yu, Xiansong Wang, Alfred S. L. Cheng, Sunny H. Wong, Ziheng Huang, Ka F. To, Xiaodong Liu, Matthew T. V. Chan, Wei Hu, Wei Kang, William K.K. Wu
Publikováno v:
Briefings in Bioinformatics. 22
Tumor suppressor genes (TSGs) exhibit distinct evolutionary features. We speculated that TSG promoters could have evolved specific features that facilitate their tumor-suppressing functions. We found that the promoter CpG dinucleotide frequencies of