Zobrazeno 1 - 10
of 279
pro vyhledávání: '"H Steve White"'
Publikováno v:
Epilepsia Open, Vol 9, Iss 4, Pp 1575-1581 (2024)
Abstract Diazepam is a cornerstone immediate‐use antiseizure rescue therapy that may extend the duration between seizure clusters in people living with epilepsy. However, our mechanistic understanding of intermittent rescue therapy on disease progr
Externí odkaz:
https://doaj.org/article/60fb88bb593d439aa933753049e68f46
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 189-206 (2009)
David C Henshall1, Nick Dürmüller2, H Steve White3, Robert Williams4, Paul Moser2, Mark Dunleavy1, Peter H Silverstone51Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland; 2Porsolt and Partners Pharm
Externí odkaz:
https://doaj.org/article/b93c28547b9c497ba789d052ac3f33bc
Autor:
Nanda A Singh, Chris Pappas, E Jill Dahle, Lieve R F Claes, Timothy H Pruess, Peter De Jonghe, Joel Thompson, Missy Dixon, Christina Gurnett, Andy Peiffer, H Steve White, Francis Filloux, Mark F Leppert
Publikováno v:
PLoS Genetics, Vol 5, Iss 9, p e1000649 (2009)
A follow-up study of a large Utah family with significant linkage to chromosome 2q24 led us to identify a new febrile seizure (FS) gene, SCN9A encoding Na(v)1.7. In 21 affected members, we uncovered a potential mutation in a highly conserved amino ac
Externí odkaz:
https://doaj.org/article/eab9b8dbd5d04ba682ae8d7d7611aa65
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Poor medication adherence contributes to increased morbidity and mortality in patients with epilepsy and may be under-addressed in clinical practice. Ethical concerns make it impossible to study the impact of medication nonadheren
Externí odkaz:
https://doaj.org/article/de2d596436934edcb2e699f96ab74cef
Autor:
Aristea S. Galanopoulou, Wolfgang Löscher, Laura Lubbers, Terence J. O’Brien, Kevin Staley, Annamaria Vezzani, Raimondo D’Ambrosio, H. Steve White, Harald Sontheimer, John A. Wolf, Roy Twyman, Vicky Whittemore, Karen S. Wilcox, Brian Klein
Publikováno v:
Epilepsia Open, Vol 6, Iss 2, Pp 276-296 (2021)
Abstract Epilepsy is one of the most common chronic brain diseases and is often associated with cognitive, behavioral, or other medical conditions. The need for therapies that would prevent, ameliorate, or cure epilepsy and the attendant comorbiditie
Externí odkaz:
https://doaj.org/article/9a03bf5010bf4758bf034af814a65c6f
Autor:
Stephanie Mizuno, Zachery Koneval, Dannielle K. Zierath, Kevin M. Knox, H. Steve White, Melissa Barker‐Haliski
Publikováno v:
Epilepsia Open, Vol 6, Iss 2, Pp 431-436 (2021)
Abstract Patients with epilepsy can experience diurnal seizure patterns. However, few studies in rodent models of temporal lobe epilepsy (TLE) routinely quantify the diurnal pattern of spontaneous recurrent seizures (SRS), and those that have conduct
Externí odkaz:
https://doaj.org/article/787f9aad571343788fa66274b7b9515b
Autor:
Wolfgang Löscher, H. Steve White
Publikováno v:
Cells, Vol 12, Iss 9, p 1233 (2023)
In the last 30 years, over 20 new anti-seizure medicines (ASMs) have been introduced into the market for the treatment of epilepsy using well-established preclinical seizure and epilepsy models. Despite this success, approximately 20–30% of patient
Externí odkaz:
https://doaj.org/article/3a72507f8fd443d89f5cc4eb977b5a65
Autor:
Gregory J. Remigio, Jaycie L. Loewen, Sage Heuston, Colin Helgeson, H. Steve White, Karen S. Wilcox, Peter J. West
Publikováno v:
Neurobiology of Disease, Vol 105, Iss , Pp 221-234 (2017)
Memory deficits have a significant impact on the quality of life of patients with epilepsy and currently no effective treatments exist to mitigate this comorbidity. While these cognitive comorbidities can be associated with varying degrees of hippoca
Externí odkaz:
https://doaj.org/article/744c4666764d4710ac43a3d5157cc44d
Autor:
Valentina Iori, Anand M. Iyer, Teresa Ravizza, Luca Beltrame, Lara Paracchini, Sergio Marchini, Milica Cerovic, Cameron Hill, Mariella Ferrari, Massimo Zucchetti, Monica Molteni, Carlo Rossetti, Riccardo Brambilla, H. Steve White, Maurizio D'Incalci, Eleonora Aronica, Annamaria Vezzani
Publikováno v:
Neurobiology of Disease, Vol 99, Iss , Pp 12-23 (2017)
We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability underlying seizures in rodents. Since this pathway is activated in neuron
Externí odkaz:
https://doaj.org/article/6e1282d045224c0cb2029a5afa349aa9
Autor:
Cameron S. Metcalf, Merodean Huntsman, Gerry Garcia, Adam K. Kochanski, Michael Chikinda, Eugene Watanabe, Tristan Underwood, Fabiola Vanegas, Misty D. Smith, H. Steve White, Grzegorz Bulaj
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Digital therapeutics (software as a medical device) and mobile health (mHealth) technologies offer a means to deliver behavioral, psychosocial, disease self-management and music-based interventions to improve therapy outcomes for chronic diseases, in
Externí odkaz:
https://doaj.org/article/0bf6569421bc4de48c7b00cf5d0b5f6b