Zobrazeno 1 - 10
of 22
pro vyhledávání: '"H Staniforth"'
Publikováno v:
Improving outcomes in community acquired pneumonia.
Background Antimicrobial resistance (AMR) is a matter of international importance. The UK government launched a 5 year plan to tackle AMR in 2019, aiming to reduce antibiotic use by 15%. NICE guidelines advocate routine microbiological testing only i
Autor:
Richard Hubbard, Thomas Bewick, H Staniforth, J Lacey, Vidya Navaratnam, E. O'Dowd, A Gummow, L Haynes
Publikováno v:
Thorax. 70:A181.2-A182
Background Hospital acquired pneumonia (HAP) is a common nosocomial condition, especially in the elderly population. We aimed to describe clinical and demographic features of patients diagnosed with HAP (excluding ventilator associated pneumonia) in
Publikováno v:
European journal of clinical pharmacology. 43(5)
The tolerance to and pharmacokinetics of intravenously administered penciclovir (BRL 39123A), a novel anti-herpes agent, were investigated in 15 healthy male subjects. The volunteers were divided into three groups, receiving either 10, 15 or 20 mg/kg
Publikováno v:
International journal of clinical pharmacology, therapy, and toxicology. 28(7)
Temocillin, a novel betalactam antibiotic, was administered in doses of 1,2 and 4 g i.v. to 12 healthy subjects and the plasma concentrations of free and protein bound temocillin assayed and protein binding parameters were calculated. In a second stu
Autor:
D. H. Staniforth, M. Pennick
Publikováno v:
European Journal of Clinical Pharmacology. 38
The activity of the substituted benzamide renzapride on the upper gastrointestinal tract has been investigated. It has been shown to enhance stomach emptying in normal subjects; doses of 2 and 5 mg decreasing by 21 and 37% respectively the volume of
Autor:
D H Staniforth
Publikováno v:
Gut. 30:978-982
The lactulose/breath hydrogen and the sulphasalazine/sulphapyridine methods of assessing orocaecal transit time have been compared. In a two part crossover study in healthy normal subjects the median orocaecal transit time by the SLZ/SP method was 4.
Publikováno v:
European Journal of Clinical Pharmacology. 17:415-418
No correlation was found between blood glucose and simultaneous measurements of plasma propranolol concentration in patients with schizophrenia, on a daily dose of 80 mg to 1800 mg of propranolol as an adjunct to phenothiazine medication. The Glucose
Publikováno v:
Journal of Antimicrobial Chemotherapy. 12:273-275
The effect of probenecid on the combination of amoxycillin/clavulanic acid has been compared with the effect on amoxycillin alone and it has been shown that probenecid, whilst producing its expected effect on amoxycillin, did not affect the clavulani
Autor:
Charles Sharp, David H. Staniforth
Publikováno v:
Drug Information Journal. 14:62-64
Publikováno v:
International journal of clinical pharmacology, therapy, and toxicology. 22(8)
The pharmacokinetics of intravenous Augmentin have been investigated and the data found to fit a two compartment model. In the first study, to a crossover design, a bolus injection of 1.2 g Augmentin was given to 8 healthy volunteers with and without