An epigenetic circuit linking oxidative stress and DNA hydroxymethylation in heart failure

Autor: Hendrik Milting, A. Walentinsson, O Franzen, S Moosmang, Mohammad Bakhtiar Hossain, R Knoll, H Siga, A Vegvari, Lars Lund, Zaher Elbeck, F Karlsson

Publikováno v: European Heart Journal. 41

Background Heart failure is a major cause of morbidity and mortality worldwide, but the underlying molecular mechanisms remain not well defined. Reactive oxygen species (ROS) in heart failure (HF) alter multitudes of mitochondrial enzymes and metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5fba2afbe741ec379fd2c4792ce2b24
https://doi.org/10.1093/ehjci/ehaa946.0919

P5435Epigenetic modifications and gene expressions in Mybpc3 knockout mice

Autor: R Knoell, Payam Haftbaradaran Esfahani, Mohammad Bakhtiar Hossain, Xing-San Li, H Siga, Zaher Elbeck

Publikováno v: European Heart Journal. 40

Background DNA methylation and hydroxymethylation plays critical role in important biological processes, including differentiation of tissues in the embryo and cellular response to different diseases and diverse environmental factors. The epigenetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94373e348b6c0b423264e419dffece7e
https://doi.org/10.1093/eurheartj/ehz746.0391

Myosin binding protein-C and hypertrophic cardiomyopathy: role of altered C10 domain

Autor: Zaher Elbeck, Ralph Knöll, Mohammad Bakhtiar Hossain, H Siga

Publikováno v: Cardiovasc Res

AIMS: A 25-base pair deletion in the cardiac myosin binding protein-C (cMyBP-C) gene (MYBPC3), proposed to skip exon 33, modifies the C10 domain (cMyBP-C(ΔC10mut)) and is associated with hypertrophic cardiomyopathy (HCM) and heart failure, affecting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1a93e86546ef8ef3eee282971ccc6f
https://pubmed.ncbi.nlm.nih.gov/31050699

Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy

Autor: Eva van Rooij, H Siga, Alejandro Hidalgo, Susanne Pehrsson, Ralph Knöll, Niels Grote Beverborg, Qing-Dong Wang, Magdalena Zurek, Rudolf A. de Boer, Regina Fritsche-Danielson, Kenny M. Hansson, Michael Frisk, Sagar S. Damle, Adam E. Mullick, Martijn F Hoes, Daniela Später, Tim R Eijgenraam, Kenneth R. Chien, Malin Palmér, Steve T Yeh, Herman H W Silljé, Cornelis J. Boogerd, William E. Louch, Tamsin Albery, Nils Bomer, Peter van der Meer, Zaher Elbeck

Publikováno v: Nature Communications, 12(1). Nature Publishing Group
Nature Communications, 12(1):5180. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications

Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathophysiology. Restoring the Ca2+ regulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b1c61196b5213b6893b0391ecf26eb

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